Interaction between P2Y and NMDA receptors in layer V pyramidal neurons of the rat prefrontal cortex

Wirkner, Kerstin; Köles, László; Thümmler, Susanne; Luthardt, Julia; Poelchen, Wolfgang; Franke, Heike; Fürst, Susanna; Illéš, Peter

doi:10.1016/s0028-3908(01)00199-x

Cited by 39 publications

(37 citation statements)

References 62 publications

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“…However, this contrasts with the current assumption about the role of ATP as co/neurotransmitter in PFC (Wirkner et al, 2002;Luthardt et al, 2003;. If ATP is co-released as a transmitter, it would cause a certain prevention of LTD induced by the pairing protocol under control LTD conditions.…”

Section: Conditions Affecting Long-term Depression 331 the Effect Omentioning

confidence: 59%

“…Regardless of its extensive action in the CNS, ATP acts in the PFC predominantly via P2Y receptors. In contrast to other brain areas (Edwards et al, 1992), in layer 5 pyramidal neurons of PFC, rapid ATP application fails to induce fast depolarizing responses (see Wirkner et al, 2002 indicating the absence of the functional ionotropic P2X receptors.…”

Section: Acute Modulation Of Synaptic Responses By Atpmentioning

confidence: 91%

“…More recently, ATP has been suggested to be co-released with dopamine and/or glutamate in PFC (Wirkner et al, 2002) acting at the postsynaptic sites of the pyramidal cells of layer 5 . Figure 1.3 shows a schematic view of the prefrontal cortex with its major interconnections.…”

Section: Connectivity and Neurochemistrymentioning

confidence: 99%

“…The PFC is a component of the mesolimbic rewarding system (Koob, 1992), and consequently is highly modulated by ATP and its metabolites, which are widely present in these structures (Krügel et al, 2001;Wirkner et al, 2002;Krügel et al, 2003). Thus, ATP is an excellent candidate for neuromodulation of the PFC through its above described receptors (i.e.…”

Section: Long-term Plasticity: Ltp and Ltdmentioning

confidence: 99%

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On the effect of ATP in long-term depression of the prefrontal cortex

Guzman¹

2018

Preprint

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Esta tesis esta dedicada a tres generaciones; a la generación de mis padres, Segundo y Carmen, por enseñarme con su ejemplo el valor del esfuerzo continuo y la absoluta dedicación. A mi propia generación, cuyos representates, mis amigos Marc y Ginés, me enseñaron el noble ejercicio de combinar reflexión con entusiasmo. Finalmente, está dedicada a la generación que viene, la generación de mi encantador y tierno hijo Antonio, el que finalmente me ha mostrado lo que es verdaderamente importante. This thesis is dedicated to three generations; the generation of my parents, Segundo and Carmen, for providing me with their example of continuous effort and absolute dedication. To my own generation, whose representatives, my friends Marc and Ginés, taught me the noble exercise of combining reflection with enthusiasm. Finally, this is dedicated to the next generation, the generation of my lovely and tender son Antonio, who ultimately showed me what is really worthy.i

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Section: Conditions Affecting Long-term Depression 331 the Effect Omentioning

confidence: 59%

Section: Acute Modulation Of Synaptic Responses By Atpmentioning

confidence: 91%

Section: Connectivity and Neurochemistrymentioning

confidence: 99%

Section: Long-term Plasticity: Ltp and Ltdmentioning

confidence: 99%

See 2 more Smart Citations

On the effect of ATP in long-term depression of the prefrontal cortex

Guzman¹

2018

Preprint

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“…In layer V pyramidal neurons of the prefrontal cortex post-synaptically localized P2Y receptors interact with NMDA receptor channels [70].…”

Section: Channel Regulation By P2 Receptorsmentioning

confidence: 99%

Interaction of purinergic receptors with GPCRs, ion channels, tyrosine kinase and steroid hormone receptors orchestrates cell function

Bilbao

Katz

Boland

2011

Purinergic Signalling

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Extracellular purines and pyrimidines have emerged as key regulators of a wide range of physiological and pathophysiological cellular processes acting through P1 and P2 cell surface receptors. Increasing evidence suggests that purinergic receptors can interact with and/or modulate the activity of other classes of receptors and ion channels. This review will focus on the interactions of purinergic receptors with other GPCRs, ion channels, receptor tyrosine kinases, and steroid hormone receptors. Also, the signal transduction pathways regulated by these complexes and their new functional properties are discussed.

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Modulation of voltage‐ and ligand‐gated ion channels by neuronal P2Y receptors

Wirkner

Köles

Fürst

et al. 2003

Drug Development Research

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The present review summarizes data about the properties, distribution, and effects of neuronal P2Y receptors. Extracellular nucleotide receptors can be classified into two types belonging either to the P2X (ligand-gated cationic channels) or the P2Y type (G protein-coupled receptors). Neuronal P2Y receptors comprise five cloned and functionally defined classes of which P2Y 1 , P2Y 6 , P2Y 11 , P2Y 12 , and P2Y 13 occur in the central nervous system. Various types of P2Y receptors stimulate inwardly rectifying potassium channels, positively or negatively modulate the high-voltage activated Ca 2+ current and increase the intracellular free Ca 2+ concentration in neuronal preparations. Moreover, in a subpopulation of pyramidal cells of the rat prefrontal cortex (PFC), the P2Y 2 receptor potentiates the function of a ligand-gated cationic channel, the N-methyl-D-aspartate (NMDA)-type excitatory amino acid receptor. This effect is G protein-mediated and utilizes the phospholipase C/inositol 1,4,5-trisphosphate/ Ca 2+ /calmodulin kinase II pathway. It appears that P2Y 2 receptors situated at astrocytes release glutamate, which in turn modulates NMDA receptors of neighbouring neurons via stimulation of group I metabotropic glutamate receptors. In contrast, P2Y 1 receptors inhibit the conductance of NMDA receptor-channels in all PFC pyramidal cells investigated. This effect is fast in onset and does not depend on G protein activation. It is suggested that P2Y 1 receptors alter the function of NMDA receptors by a direct protein-protein coupling in the membrane. Because ATP and dopamine are supposed to be coreleased from dopaminergic fibers onto layer V pyramidal cells, both neurotransmitters may interact with the neuronal NMDA receptor. Hence, D 1 dopamine receptors and P2Y 1 /P2Y 2 receptors may be involved in the fine tuning of higher order cognitive functions including learning and memory. Drug Dev. Res. 59:49-55, 2003.

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Interaction between P2Y and NMDA receptors in layer V pyramidal neurons of the rat prefrontal cortex

Cited by 39 publications

References 62 publications

On the effect of ATP in long-term depression of the prefrontal cortex

On the effect of ATP in long-term depression of the prefrontal cortex

Interaction of purinergic receptors with GPCRs, ion channels, tyrosine kinase and steroid hormone receptors orchestrates cell function

Modulation of voltage‐ and ligand‐gated ion channels by neuronal P2Y receptors

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