Interaction between Omeprazole and Gliclazide in Relation to CYP2C19 Phenotype

Dujić, Tanja; Cvijić, Sandra; Elezovic, A; Bego, Tamer; Kadric, Selma Imamovic; Malenica, Maja; Pearson, Ewan R.; Kulo, Aida

doi:10.3390/jpm11050367

Cited by 6 publications

(3 citation statements)

References 58 publications

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“…In the first case (benzodiazepine + venlafaxine), caution is recommended with this association because it may increase the incidence and severity of ADRs [ 55 ]. In the second one, omeprazole may augment the risk of hypoglycemia associated with gliclazide in most patients, as the oral antidiabetic is metabolised by CYP2C19, and omeprazole is an inhibitor of this enzyme [ 56 ]. Finally, the interaction known as the triple whammy (angiotensin converting enzyme inhibitors/angiotensin-II receptor blockers (ACEI/ARBs) + diuretic + nonsteroidal anti-inflammatory drugs (NSAIDs)) was detected by CheckTheMeds, but not by the other two databases, which worked only with pairs of drugs.…”

Section: Discussionmentioning

confidence: 99%

Drug-Related Problems and Polypharmacy in Nursing Home Residents: A Cross-Sectional Study

Díez

Cadenas

Susperregui

et al. 2022

IJERPH

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At present, 19.2% of the Spanish population is aged 65 or older. Polypharmacy is a frequent condition among the elderly, especially in those living in nursing homes, which is associated with adverse outcomes, such as adverse drug events or drug-drug interactions. This study aimed to assess the pattern of polypharmacy in a nursing home in Leon, one of Spain’s most ageing regions, and its relationship with different drug-related problems. A descriptive, observational, and cross-sectional study design was used; 222 residents were involved in this study. Data on drug use were collected from medical charts. Information was screened with the software CheckTheMeds, BOT PLUS and Drug-Reax. Residents were on a median of 7 medicines. Polypharmacy and inappropriate medications were present in 78.8% and 96.8% of residents, respectively. Drug-related problems were present in almost all the populations evaluated. Drug-drug interactions were very common in participants (81.1%), being severe/moderate in 24.7%. A high prevalence of polypharmacy and drug-related problems in the nursing home population assessed has been observed. A significantly higher risk of suffering drug-drug interactions was revealed for increasing polypharmacy and anticholinergic risk. A regular evaluation of drug prescribing in nursing home residents is necessary to minimize drug-related problems risk.

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Section: Discussionmentioning

confidence: 99%

Drug-Related Problems and Polypharmacy in Nursing Home Residents: A Cross-Sectional Study

Díez

Cadenas

Susperregui

et al. 2022

IJERPH

View full text Add to dashboard Cite

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“…Another study showed that omeprazole might increase the risk of hypoglycemia in most patients treated with gliclazide. [13] Several studies have shown the presence of H. pylori infection affects the incidence of insulin resistance and metabolic syndromes [14]. Furthermore, H. pylori treatment can improve the mean level of glycosylated hemoglobin in patients with type 2 diabetes [10].…”

Section: Discussionmentioning

confidence: 99%

Triple therapy for Helicobacter pylori eradication and the risk of hypoglycemia in patients with diabetes: A population-based cohort study

Chang

Chen

et al. 2023

Preprint

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The incidence of type 2 diabetes mellitus has risen globally, from 108 million cases in 1980 to 422 million cases in 2014. Although controlling glycemic levels in patients with diabetes is crucial, improper management can lead to hypoglycemic episodes and even potentially fatal events such as comas, seizures, life-threatening arrhythmias, and myocardial infarctions. Several antibiotics have been documented to cause hypoglycemic episodes; the use of antibiotics along with certain diabetic medications might further increase the risk of hypoglycemia. Therefore, researchers must determine which treatments against which types of infection carry a risk of inducing severe hypoglycemic events. The prevalence of H. pylori infection remains high in most countries, and the infection is often treated with triple therapy involving amoxicillin, clarithromycin, and a proton pump inhibitor (PPI). Several case reports have reported that hypoglycemia can occur when any one of them are used with patients who also take diabetes medication. Therefore, we hypothesized that patients with diabetes might experience hypoglycemic episodes when being treated with triple therapy for H. pylori infection. By analyzing medical records from Taiwan’s National Health Insurance Research Database, we found a significant association between hypoglycemia and triple therapy treatment for diabetic patients with peptic ulcer. Prescribing triple therapy to patients with diabetes and peptic ulcers significantly increase the risk of a hypoglycemic episode (adjusted odds ratio [aOR] = 1.75, 95% confidence interval [CI]: 1.64 to 1.88, P < 0.001). Similarly, the highest aOR (5.77, 95% CI 4.82 to 6.92) was found in patients with diabetes and peptic ulcers who had hypoglycemic episodes within 30 days after triple therapy treatment. Many patients with diabetes require H.pylori eradication for peptic ulcer treatment, and vigilance toward the risk of hypoglycemia in this population is thus necessary.

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“…PPIs can significantly raise serum gastrin concentration and affect glucose metabolism by promoting B-cell regeneration and expansion; PPIs can therefore increase the risk of hypoglycemia. Another study showed that omeprazole might increase the risk of hypoglycemia inpatients treated with gliclazide [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Triple therapy for Helicobacter pylori eradication and the risk of hypoglycemia in patients with diabetes: a population-based cohort study

Chang,

Chen

et al. 2023

BMC Public Health

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The incidence of type 2 diabetes mellitus has risen globally, from 108 million cases in 1980 to 422 million cases in 2014. Although controlling glycemic levels in patients with diabetes is crucial, insulin and sulfonylureas can cause hypoglycemic episodes and even potentially fatal events such as comas, seizures, life-threatening arrhythmias, and myocardial infarctions. Several antibiotics have been documented to cause hypoglycemic episodes; the use of antibiotics along with insulin or sulfonylureas might further increase the risk of hypoglycemia. Therefore, researchers must determine which antibiotics carry a risk of inducing severe hypoglycemic events. The prevalence of H. pylori infection remains high in most countries, and the infection is often treated with triple therapy involving amoxicillin, clarithromycin, and a proton pump inhibitor (PPI). Several case reports have reported that hypoglycemia can occur when used with patients who also take diabetes medication. Therefore, we hypothesized that patients with diabetes have an increased risk of hypoglycemic episodes when being treated with triple therapy for H. pylori infection. By analyzing medical records from Taiwan’s National Health Insurance Research Database, we found a significant association between hypoglycemia and triple therapy treatment for diabetic patients with peptic ulcer disease. Prescribing triple therapy to patients with diabetes and peptic ulcers significantly increased the risk of a hypoglycemic episode (adjusted odds ratio [aOR] = 1.75, 95% confidence interval [CI]: 1.64 to 1.88, P < 0.001). Similarly, the highest aOR (5.77, 95% CI 4.82 to 6.92) was found in patients with diabetes and peptic ulcers who had hypoglycemic episodes within 30 days after triple therapy treatment. Many patients with diabetes require H.pylori eradication for peptic ulcer treatment, and vigilance toward the risk of hypoglycemia in this population is thus necessary.

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Interaction between Omeprazole and Gliclazide in Relation to CYP2C19 Phenotype

Cited by 6 publications

References 58 publications

Drug-Related Problems and Polypharmacy in Nursing Home Residents: A Cross-Sectional Study

Drug-Related Problems and Polypharmacy in Nursing Home Residents: A Cross-Sectional Study

Triple therapy for Helicobacter pylori eradication and the risk of hypoglycemia in patients with diabetes: A population-based cohort study

Triple therapy for Helicobacter pylori eradication and the risk of hypoglycemia in patients with diabetes: a population-based cohort study

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