Interaction Between Oestrogen and Oxytocin on Hypothalamic‐Pituitary‐Adrenal Axis Activity

Ochędalski, Tomasz; Subburaju, Sivan; Wynn, Peter; Aguilera, Greti

doi:10.1111/j.1365-2826.2006.01525.x

Cited by 112 publications

(86 citation statements)

References 63 publications

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“…Stress-induced activation of the HPA axis can disrupt secretion of LH into plasma, as well as sex steroid synthesis and release (30). In fact, the sex hormone E2 can act and interact on/with both basal and stress-induced HPA function, influencing adrenocorticoid synthesis, stressinduced adrenocorticotropic hormone (ACTH) and glucocorticoid release, and CRH synthesis by the hypothalamus (31). CRH is a primary neurohormone that activates the HPA axis and has been suggested to be one of the primary targets for E2, in which ER binds to the ERE on the CRH promoter in human (31,32).…”

Section: Discussionmentioning

confidence: 99%

“…In fact, the sex hormone E2 can act and interact on/with both basal and stress-induced HPA function, influencing adrenocorticoid synthesis, stressinduced adrenocorticotropic hormone (ACTH) and glucocorticoid release, and CRH synthesis by the hypothalamus (31). CRH is a primary neurohormone that activates the HPA axis and has been suggested to be one of the primary targets for E2, in which ER binds to the ERE on the CRH promoter in human (31,32). Taken together, these results suggested that PCZ could down-regulate expression of some HPA axis genes and decrease concentrations of cortisol by reducing the concentration of E2.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Prochloraz or Propylthiouracil on the Cross-Talk between the HPG, HPA, and HPT Axes in Zebrafish

Liu

Zhang

Deng

et al. 2010

Environ. Sci. Technol.

118

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The objective of this study was to assess chemical-induced effects on cross-talk among the hypothalamic-pituitary-gonad (HPG), hypothalamic-pituitary-adrenal (HPA), and hypothalamic-pituitary-thyroid (HPT) axes of fish. Adult female zebrafish were exposed to 300 µg/L prochloraz (PCZ) or 100 mg/L propylthiouracil (PTU), and the transcriptional profiles of the HPG, HPA, and HPT axes were examined. Exposure to PCZ decreased plasma testosterone (T) and 17 -estradiol (E2) concentrations and affected HPA and HPT axes by downregulating corticotrophin-releasing hormone (CRH) after 12 and 48 h. By using correlation analyses, it was found that the decrease in E2 plasma concentrations caused by PCZ was correlated with the down-regulation of CRH mRNA expression. Exposure to PTU resulted in lesser concentrations of thyroxine (T4) and triiodothyronine (T3), greater concentrations of follicle stimulating hormone (FSH) and luteinizing hormone (LH) peptides, and increase in steroidogenic gene expression after 12 and 48 h. Concentrations of FSH and LH were negatively correlated with concentrations of T4 and T3. These results are consistent with the hypothesis that increased steroidogenic gene expression after PTU exposure resulted from a reduction in T4 and T3 concentrations, which resulted in greater secretion of FSH and LH.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Prochloraz or Propylthiouracil on the Cross-Talk between the HPG, HPA, and HPT Axes in Zebrafish

Liu

Zhang

Deng

et al. 2010

Environ. Sci. Technol.

118

View full text Add to dashboard Cite

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“…However, a coordination of central and peripheral OT effects may also be facilitated indirectly, e.g. via steroid hormones (Bos et al, 2012;McCarthy, 1995;Ochedalski et al, 2007) and bidirectional feedback mechanisms with peripheral organs and body states (Goodson and Thompson, 2010). Such a coordination may also be dependent on the involved stimulating brain regions (Martínez-Lorenzana et al, 2008).…”

mentioning

confidence: 99%

Oxytocin is associated with infant-care behavior and motivation in cooperatively breeding marmoset monkeys

Finkenwirth

Martins

Deschner

et al. 2016

Hormones and Behavior

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The neurohormone oxytocin (OT) is positively involved in the regulation of parenting and social bonding in mammals, and may thus also be important for the mediation of alloparental care. In cooperatively breeding marmosets, infants are raised in teamwork by parents and adult and subadult non-reproductive helpers (usually older siblings). Despite high intrinsic motivation, which may be mediated by hormonal priming, not all individuals are always equally able to contribute to infant-care due to competition among care-takers. Among the various care-taking behaviors, proactive food sharing may reflect motivational levels best, since it can be performed ad libitum by several individuals even if competition among surplus care-takers constrains access to infants. Our aim was to study the link between urinary OT levels and care-taking behaviors in group-living marmosets, while taking affiliation with other adults and infant age into account. Over eight reproductive cycles, 26 individuals were monitored for urinary baseline OT, care-taking behaviors (baby-licking, -grooming, -carrying, and proactive food sharing), and adult-directed affiliation. Mean OT levels were generally highest in female breeders and OT increased significantly in all individuals after birth. During early infancy, high urinary OT levels were associated with increased infant-licking but low levels of adult-affiliation, and during late infancy, with increased proactive food sharing. Our results show that, in marmoset parents and alloparents, OT is positively involved in the regulation of care-taking, thereby reflecting the changing needs during infant development. This particularly included behaviors that are more likely to reflect intrinsic care motivation, suggesting a positive link between OT and motivational regulation of infant-care. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Email: christa.finkenwirth@uzh.ch A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT AbstractThe neurohormone oxytocin (OT) is positively involved in the regulation of parenting and social bonding in mammals, and may thus also be important for the mediation of alloparental care. In cooperatively breeding marmosets, infants are raised in teamwork by parents and adult and subadult non-reproductive helpers (usually older siblings). Despite high intrinsic motivation, which may be mediated by hormonal priming, not all individuals are always equally able to contribute to infant-care due to competition among care-takers. Among the various care-taking behaviors, proactive food sharing may reflect motivational levels best, since it can be performed ad libi...

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“…Although several reports on the effect of E 2 on the HPA axis performed in cell cultures and animal models (rats, sheep) are available (McCormick et al 1998;Ochedalski et al 2007;Ogura et al 2008;Kageyama and Suda 2009;Weiser and Handa 2009;Handa and Weiser 2014;van Lier et al 2014), the mechanisms have not yet been fully elucidated. In general, it has been proposed that E 2 could exert a stimulatory effect on the hypothalamus, the corticotroph cells or the adrenal gland cortex (by stimulating CRH secretion or inhibiting glucocorticoid feedback, or stimulating ACTH synthesis or cortisol synthesis/secretion) (Burgess and Handa 1993;Carey et al 1995;McCormick et al 1998;Lo et al 2000;van Lier et al 2003b;Ochedalski et al 2007; Kageyama and Suda 2009;Weiser and Handa 2009;Handa and Weiser 2014;Panagiotakopoulos and Neigh 2014).…”

mentioning

confidence: 99%

Plasma ACTH, α-MSH and cortisol variations in the dog during the oestrous cycle in different photoperiods

Gallelli¹,

Monachesi²,

Miceli³

et al. 2015

Vet. Med. - Czech

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ABSTRACT:The hypothalamic-pituitary-adrenal axis (HPA) is a complex system regulated by multiple factors. Sexual dimorphism of this axis has been described in different species under physiological conditions and it has been proposed that sexual hormones could have an effect on it. There are only a few reports about sex-linked variations in HPA axis hormones in the dog. Thus, studying the impact of sexual hormones on the HPA axis would broaden the knowledge about its function in this species. Therefore, the objective of this study was to determine whether there are variations in HPA plasma hormones (ACTH, alfa-melanocyte-stimulating hormone [α-MSH] and cortisol) according to the sex and photoperiod (positive or negative photoperiod were considered when the duration of the light hours of the day was more than 12 or less than 12, respectively) under basal conditions (like anoestrus) and throughout the oestrous cycle in the female dog. The population under study consisted of 11 intact female and 14 intact male dogs. Under basal conditions neither ACTH nor α-MSH concentrations showed differences between sexes and different photoperiods. Cortisol showed greater values in the negative photoperiod than in the positive, both in females and males (P = 0.03 and P = 0.015, respectively). Throughout the oestrous cycle, all the studied hormones showed variations (P < 0.0001). The greatest concentrations of ACTH were observed at proestrus, while α-MSH and cortisol showed their greatest concentrations at oestrus. The three hormones decreased in diestrus. ACTH and cortisol concentrations were higher in the negative photoperiod (P = 0.04 and P < 0.0001, respectively), while α-MSH concentrations were higher in the positive photoperiod (P = 0.012). In the group of females oestradiol and progesterone correlated with ACTH (r = 0.75, P < 0.0001; r = 0.34, P < 0.01, respectively), α-MSH (r = 0.49, P < 0.0001; r = 0.52, P < 0.0001, respectively) and cortisol (r = 0.33, P < 0.01; r = 0.5, P < 0.0001, respectively). These results show that in females, HPA axis hormones vary during the oestrous cycle in relation to oestradiol and progesterone fluctuations. The ACTH, α-MSH and cortisol concentrations also showed differences between photoperiods in females, but only cortisol did so in males. These findings suggest that sexual hormones could have an effect on the HPA axis. Further research needs to be done to fully understand this interaction and the mechanisms involved.

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Interaction Between Oestrogen and Oxytocin on Hypothalamic‐Pituitary‐Adrenal Axis Activity

Cited by 112 publications

References 63 publications

Effects of Prochloraz or Propylthiouracil on the Cross-Talk between the HPG, HPA, and HPT Axes in Zebrafish

Effects of Prochloraz or Propylthiouracil on the Cross-Talk between the HPG, HPA, and HPT Axes in Zebrafish

Oxytocin is associated with infant-care behavior and motivation in cooperatively breeding marmoset monkeys

Plasma ACTH, α-MSH and cortisol variations in the dog during the oestrous cycle in different photoperiods

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