Interaction between nutrition and <i>Eimeria acervulina</i> infection in broiler chickens: development of an experimental infection model

Adams, C.; Vahl, H. A.; Veldman, A.

doi:10.1079/bjn19960192

Cited by 51 publications

(31 citation statements)

References 12 publications

(9 reference statements)

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“…Significant differences regarding clinical disease or FCR could not be seen between the animals of different study groups in both trials. The typical coccidia-induced depression of feed intake five days after coccidia infection is consistent with previous descriptions (Adams and others 1996) was observed in both trials and intensified by C perfringens infection. Oocyst excretion and the extent of Eimeria species typical lesions were promoted notably by a following C perfringens infection in both infection models compared with groups infected with either coccidia or clostridia alone.…”

Section: Discussionsupporting

confidence: 92%

Necrotic enteritis in chickens: development of a straightforward disease model system

Alnassan¹,

Kotsch

Shehata

et al. 2014

Veterinary Record

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The interaction between Eimeria species and Clostridium perfringens was investigated in two different necrotic enteritis (NE) models: 120-day-old broilers were used in two separate experiments consisting of six groups (n=10) each. Besides controls, chickens were infected with coccidia on study day (SD) 18 (Eimeria maxima and Eimeria acervulina (experiment 1) or Eimeria tenella and Eimeria brunetti (experiment 2) and/or a NetB toxin positive C perfringens strain (both experiments: SD 14 or SD 22, respectively)). Body weight, feed intake, mortality rate, clinical disease, Eimeria species oocyst excretion and C perfringens counts were recorded. NE and coccidiosis specific lesion scores were assessed (SD 24 and SD 30). In coinfected groups, NE-typical clinical signs occurred. Coccidiosis-specific lesions were most severe in coinfected groups (significant for E tenella, P<0.05). Most pronounced NE lesions occurred in coinfected chickens compared with C perfringens monoinfected groups (experiment 2, C perfringens infections on SD 22: P<0.05). In experiment 2, E tenella antibody levels were (non-significantly) higher in coinfected groups than in Eimeria species monoinfected groups. Thus, infection with E tenella and Eimeria brunetti followed by C perfringens inoculation is regarded as an easy to handle and suitable model for investigations into NE of chickens.

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Section: Discussionsupporting

confidence: 92%

Necrotic enteritis in chickens: development of a straightforward disease model system

Alnassan¹,

Kotsch

Shehata

et al. 2014

Veterinary Record

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“…In present study, significantly increased oocysts numbers were recorded in control group than those of administered with purified beta-glucans. The chickens in control groups were observed depressed, lethargic and dull with ruffled feather and irregular feed and water intake (Personal observations) that may lead to alteration in gut homeostasis, altered metabolism and lower body weight gains, (McKenzie et al, 1987;Adams et al, 1996;Kettunen et al, 2001). The pathogenic Eimeria species seriously affect the enteric microenvironment and ultimately cytokines production, which lead to physiological changes and increased hemorrhagic lesions (Allen, 1997).…”

Section: Discussionmentioning

confidence: 99%

Immunological and Therapeutic Evaluation of Wheat (Triticum aestivum) Derived Betaglucans against Coccidiosis in Chicken

Rizwan¹,

Khan²,

Iqbal³

et al. 2016

IJAB

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To cite this paper: Rizwan, H.M., M.K. Khan, Z. Iqbal and F. Deeba, 2016. Immunological and therapeutic evaluation of wheat (Triticum aestivum) derived beta-glucans against coccidiosis in chicken. AbstractThis study was carried out to determine the immunomodulatory and therapeutic effects of wheat derived beta-glucans (purified) against avian coccidiosis. Briefly, beta-glucans from wheat bran were extracted and purified using standard procedures. A total of 250 broiler chicks (day-old) were reared at experimental station, Department of Parasitology, University of Agriculture, Faisalabad for this study. At 7 th day of their age, birds were subdivided into five equal groups (n=50). Groups A, B and C were orally administered with graded doses of purified beta-glucans (50, 100 and 150 mg/kg of body weight) for three consecutive days; whereas, positive control (group D) was administered with vitamin-E at the dose rate of 87mg/kg; while negative control (group E) was served with phosphate buffered saline (PBS solution). At 14 th day post administration of graded doses, 30 chickens from each group were randomly selected and used to monitor cellular and humoral immune responses, while remaining birds (n=20) in each group were challenged with mixed species of genus Eimeria for therapeutic evaluation. Overall, chickens in group A administered with 50 mg/kg b.wt. purified beta-glucans showed significantly higher immune responses in terms of enhanced humoral and cell mediated immunity as compared to those of other beta-glucans administered and E groups. While, the immune responses showed by group A were comparable with group D. After challenge with Eimeria, the groups A and D also showed maximum weight gains with low oocyst counts and maximum percent protection against lesions in both caecum and intestine. On the other hand, a minimum daily weight gain with increased number of oocysts in chickens was observed in control group (PBS) during therapeutic evaluation. These findings suggest that the beta-glucans derived from wheat may have immunomodulatory and therapeutic effects against Eimeria infection in chickens.

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“…Structural and functional damages to the small intestine are indicated by the histomorphology, digestive enzymes, nutrients transporters, and nutrient retention in our model (84,86,87). Moreover, E. acervulina and E. maxima infection down regulates expression of digestive enzymes and nutrient transporters (84,87,(93)(94)(95). Subsequent sections will evaluate literature where coccidiosis challenge was used to evaluate impact feed enzymes and yeast derivatives in modulating the expression of coccidiosis.…”

Section: Utility Of Feed Enzymes and Yeast Derivatives In Mitigating mentioning

confidence: 99%

Utility of Feed Enzymes and Yeast Derivatives in Ameliorating Deleterious Effects of Coccidiosis on Intestinal Health and Function in Broiler Chickens

et al. 2019

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Interaction between nutrition and Eimeria acervulina infection in broiler chickens: development of an experimental infection model

Cited by 51 publications

References 12 publications

Necrotic enteritis in chickens: development of a straightforward disease model system

Necrotic enteritis in chickens: development of a straightforward disease model system

Immunological and Therapeutic Evaluation of Wheat (Triticum aestivum) Derived Betaglucans against Coccidiosis in Chicken

Utility of Feed Enzymes and Yeast Derivatives in Ameliorating Deleterious Effects of Coccidiosis on Intestinal Health and Function in Broiler Chickens

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