Interaction between nerve growth factor and lysophosphatidylserine on rat peritoneal mast cells

Bruni, A.; Bigon, E.; Boarato, E.; Mietto, L.; Leon, Alberta; Toffano, G.

doi:10.1016/0014-5793(82)80438-9

Cited by 162 publications

(61 citation statements)

References 14 publications

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“…48 However, the expression and, presumably, functions of NTs and their highaffinity receptors for NTs differ between MCs from humans and mice and also between different human tissues and human cell lines. 9,14,15,[18][19][20][21][22][23][24][25][26]48 In our study, we could demonstrate for the first time significantly higher circulating levels of the NTs NGF-b, NT-3, and NT-4 and increased migration of CD117 1 cells from the blood toward an NGF gradient via TrkA. NTs might contribute to the augmented MC tissue infiltration in mastocytosis via increased migration of MC progenitor cells toward NGF and/or stimulation of MC differentiation and proliferation by NGF and NT-3.…”

Section: Discussionmentioning

confidence: 99%

Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis

Peng

Maintz

Allam

et al. 2013

Blood

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Section: Discussionmentioning

confidence: 99%

Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis

Peng

Maintz

Allam

et al. 2013

Blood

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“…NGF also directly stimulates degranulation of mast cells, increases the number of mast cells in peripheral tissues and promotes cell growth of myeloid cells (120,411,626), induces proliferation and differentiation of B cells, and enhances histamine release from basophils. NGF is also capable of stimulating IL-1 expression in PC12 cells and suppressing LTC 4 production in human eosinophils (13,846).…”

Section: Ngf and Cutaneous Inflammationmentioning

confidence: 99%

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Roosterman¹,

Goerge

Schneider

et al. 2006

Physiological Reviews

547

521

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This review focuses on the role of the peripheral nervous system in cutaneous biology and disease. During the last few years, a modern concept of an interactive network between cutaneous nerves, the neuroendocrine axis, and the immune system has been established. We learned that neurocutaneous interactions influence a variety of physiological and pathophysiological functions, including cell growth, immunity, inflammation, pruritus, and wound healing. This interaction is mediated by primary afferent as well as autonomic nerves, which release neuromediators and activate specific receptors on many target cells in the skin. A dense network of sensory nerves releases neuropeptides, thereby modulating inflammation, cell growth, and the immune responses in the skin. Neurotrophic factors, in addition to regulating nerve growth, participate in many properties of skin function. The skin expresses a variety of neurohormone receptors coupled to heterotrimeric G proteins that are tightly involved in skin homeostasis and inflammation. This neurohormone-receptor interaction is modulated by endopeptidases, which are able to terminate neuropeptide-induced inflammatory or immune responses. Neuronal proteinase-activated receptors or transient receptor potential ion channels are recently described receptors that may have been important in regulating neurogenic inflammation, pain, and pruritus. Together, a close multidirectional interaction between neuromediators, high-affinity receptors, and regulatory proteases is critically involved to maintain tissue integrity and regulate inflammatory responses in the skin. A deeper understanding of cutaneous neuroimmunoendocrinology may help to develop new strategies for the treatment of several skin diseases.

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“…MC express NGF-r (70)(71)(72)(73) and in vitro administration of NGF induces MC degranulation and histamine release (70,74), increasing their survival (72,75) (Fig. 1).…”

Section: Ngf and The Immune Systemmentioning

confidence: 99%

The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases

Aloe

Bracci-Laudiero

Бонини

et al. 1997

Allergy

203

127

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Numerous studies published in the last 10–15 years have shown that nerve growth factor (NGF), a polypeptide originally discovered in connection with its neurotrophic activity, also acts on cells of the immune system. NGF has been found in various immune organs including the spleen, lymph nodes, and thymus, and cells such as mast cells, eosinophils, and B and T cells. The circulating levels of NGF increase in inflammatory responses, in various autoimmune diseases, in parasitic infections, and in allergic diseases. Stress‐related events both in animal models and in man also result in an increase of NGF, suggesting that this molecule is involved in neuroendocrine functions. The rapid release of NGF is part of an alerting signal in response to either psychologically stressful or anxiogenic conditions in response to homeostatic alteration. Thus, the inflammation and stress‐induced increase in NGF might alone or in association with other biologic mediators induce the activation of immune cells during immunologic insults. A clearer understanding of the role of NGF in these events may be useful to identify the mechanisms implicated in certain neuroimmune and immune dysfunctions.

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Interaction between nerve growth factor and lysophosphatidylserine on rat peritoneal mast cells

Cited by 162 publications

References 14 publications

Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis

Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases

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