Interaction between Myocardial and Vascular Changes in Obese Children: A Pilot Study

Koopman, Laurens P.; McCrindle, Brian W.; Slorach, Cameron; Chahal, Nita; Wang, Hui; Sarkola, Taisto; Manlhiot, Cedric; Jaeggi, Edgar; Bradley, Timothy J.; Mertens, Luc

doi:10.1016/j.echo.2011.12.018

Cited by 85 publications

(71 citation statements)

References 40 publications

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“…Cardiovascular risk has been described not only in obese adults but also in obese children and adolescents (5)(6)(7)(8)27 Recent studies indicate that this trend of subclinical depression in LV function among obese subjects is observed in the pediatric years (7,13). Therefore, LV peak systolic longitudinal strain and SR values were significantly reduced in these patients combined strain imaging studies (2,8,11,17,18,28).…”

Section: Discussionmentioning

confidence: 91%

“…Therefore, LV peak systolic longitudinal strain and SR values were significantly reduced in these patients combined strain imaging studies (2,8,11,17,18,28). The effect of obesity on left ventricular myocardial function has shown an early finding during childhood (5, 7).…”

Section: Discussionmentioning

confidence: 99%

“…It is clear that this method is useful in obesity (7,13,30). Previous studies of obesity LV function to show subclinical abnormalities was used color Doppler strain or 2D speckle tracking strain (7,8,11,13,(18)(19)(20)30). Barbosa et al (7) reported 50 obese children without comorbidities in 2D speckle tracking analysis, a significant reduction in the longitudinal strain association with BMI.…”

Section: Discussionmentioning

confidence: 99%

“…These strain parameters are affected to a much lesser extent by cardiac rotation and passive cardiac motion (2,11,16). Previous studies have demonstrated decreased regional myocardial function related to body mass index (BMI) by strain imaging studies (7,8,11,13,(17)(18)(19)(20).…”

mentioning

confidence: 99%

“…Obesity and cardiac involvement has been reported frequently in the literature, but analysis of regional myocardial function in children by two-dimensional (2D) speckle tracking echocardiography (STE) is rarely documented (4)(5)(6)(7)(8).…”

mentioning

confidence: 99%

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Effect of Obesity on Left Ventricular Longitudinal Myocardial Strain by Speckle Tracking Echocardiography in Children and Adolescents

et al. 2015

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Background: Impaired subclinical ventricular function may contribute to the risk of cardiovascular disease in obesity. Aims: The aim of this study was to determine the influence of obesity on left ventricular (LV) longitudinal myocardial function in normotensive obese children using two-dimensional (2D) speckle tracking echocardiography (STE). Study Design: Case-control study. Methods: Sixty normotensive obese children aged 10-16 years (mean age, 13.9±2.3 years) were compared with 50 normal-weight controls. Obese participants had a body mass index (BMI)≥95 th percentile. Regional strain/strain rate (SR) values were compared with left ventricular (LV) parameters. The correlation was studied by linear regression analysis. Results: Obese subjects exhibited a significantly higher LV end-diastolic diameter, left atrium/aortic diameter ratio, and LV mass/index when compared to controls (p<0.001). Left ventricular ejection fraction and regional systolic myocardial velocities were similar in the obese and control groups. By 2D STE, regional strain of both the septal wall (average strain:

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Effect of Obesity on Left Ventricular Longitudinal Myocardial Strain by Speckle Tracking Echocardiography in Children and Adolescents

et al. 2015

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Of mice (dogs) and men: getting to the heart of obesity-associated cardiac dysfunction

2015

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Increased Regional Deformation of the Left Ventricle in Normal Children With Increased Body Mass Index: Implications for Future Cardiovascular Health

et al. 2013

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The prevalence of obesity continues to increase in the developing world. The effects of obesity on the cardiovascular system include changes in systolic and diastolic function. More recently obesity has been linked with impairment of longitudinal myocardial deformation properties in children. We sought to determine the effect of increased body mass index (BMI) on cardiac deformation in a group of children taking part in the population-based Southampton Women's Survey to detect early cardiovascular changes associated with increasing BMI before established obesity. Sixty-eight children at a mean age of 9.4 years old underwent assessment of longitudinal myocardial deformation in the basal septal segment of the left ventricle (LV) using two-dimensional speckle tracking echocardiography. Parameters of afterload and preload, which may influence deformation, were determined from cardiac magnetic resonance imaging. BMI was determined from the child's height and weight at the time of echocardiogram. Greater pediatric BMI was associated with greater longitudinal myocardial deformation or strain in the basal septal segment of the LV (β = 1.6, p < 0.001); however, this was not related to contractility or strain rate in this part of the heart (β = 0.001, p = 0.92). The end-diastolic volume of the LV increased with increasing BMI (β = 3.93, p < 0.01). In young children, regional deformation in the LV increases with increasing BMI, whilst normal contractility is maintained. This effect may be explained by the increased preload of the LV associated with increased somatic growth. The long-term implications of this altered physiology need to be followed-up.

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Interaction between Myocardial and Vascular Changes in Obese Children: A Pilot Study

Cited by 85 publications

References 40 publications

Effect of Obesity on Left Ventricular Longitudinal Myocardial Strain by Speckle Tracking Echocardiography in Children and Adolescents

Effect of Obesity on Left Ventricular Longitudinal Myocardial Strain by Speckle Tracking Echocardiography in Children and Adolescents

Of mice (dogs) and men: getting to the heart of obesity-associated cardiac dysfunction

Increased Regional Deformation of the Left Ventricle in Normal Children With Increased Body Mass Index: Implications for Future Cardiovascular Health

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