Interaction between microRNA expression and classical risk factors in the risk of coronary heart disease

Ding, Xueqin; Ge, Peng-Cheng; Liu, Zhe; Jia, Hongliang; Chen, Xi; An, Feng-Hui; Li, Lihua; Chen, Zhaohong; Mao, Hong-Wei; Li, Zhaoyang; Gu, Yan; Zhu, Tongyu; Li, Chunjian; Wang, Liansheng; Ma, Wei; Yang, Zhaohui; Jia, En-Zhi

doi:10.1038/srep14925

Cited by 37 publications

(31 citation statements)

References 63 publications

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“…Non-coding RNA-based approaches provide new opportunities to develop novel biomarkers. Small RNAs such as microRNAs (miRNAs) have been proposed as sensitive and specific biomarkers of cardiovascular disease2425. Extracellular lncRNAs are potent biomarkers in cancer26.…”

Section: Discussionmentioning

confidence: 99%

Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes

Gonzalo-Calvo

Kenneweg

Bang

et al. 2016

Sci Rep

130

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Contractile dysfunction is underdiagnosed in early stages of diabetic cardiomyopathy. We evaluated the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers of subclinical cardiac abnormalities in type 2 diabetes. Forty-eight men with well-controlled type 2 diabetes and 12 healthy age-matched volunteers were enrolled in the study. Left ventricular (LV) parameters were measured by magnetic resonance imaging. A panel of lncRNAs was quantified in serum by RT-qPCR. No differences in expression levels of lncRNAs were observed between type 2 diabetes patients and healthy volunteers. In patients with type 2 diabetes, long intergenic non-coding RNA predicting cardiac remodeling (LIPCAR) was inversely associated with diastolic function, measured as E/A peak flow (P < 0.050 for all linear models). LIPCAR was positively associated with grade I diastolic dysfunction (P < 0.050 for all logistic models). Myocardial infarction-associated transcript (MIAT) and smooth muscle and endothelial cell-enriched migration/differentiation-associated long noncoding RNA (SENCR) were directly associated with LV mass to LV end-diastolic volume ratio, a marker of cardiac remodelling (P < 0.050 for all linear models). These findings were validated in a sample of 30 patients with well-controlled type 2 diabetes. LncRNAs are independent predictors of diastolic function and remodelling in patients with type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes

Gonzalo-Calvo

Kenneweg

Bang

et al. 2016

Sci Rep

130

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“…Based on previous studies [28], nine CHD-related miRNAs were proposed as candidates in the study. This includedmiR-122, miR-133b [29], miR-214 [30], miR-21, miR-106a [31], miR-130a, miR-155, miR-221 [32], and miR-125b [33-36].…”

Section: Subject and Methodsmentioning

confidence: 99%

“…Another interesting characteristic of disease-specific miRNAs is that they may be ethnicity specific [20]. Moreover, accumulating evidence indicates that some miRNAs may be specific for patients with CHD [21]. However, the potential role of these miRNAs in multi-ethnic CHD patients has rarely been reported.…”

Section: Introductionmentioning

confidence: 99%

Predictive Effects of Circulating miR-221, miR-130a and miR-155 for Coronary Heart Disease: A Multi-Ethnic Study in China

Jia

Chen

Ding

et al. 2017

Cell Physiol Biochem

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Background: Differences in microRNA (miRNA) profiles between patients with and without coronary heart disease (CHD)have not been fully determined. The purpose of the study was to evaluate in a multi-ethnic population in China the predictive value of miRNAs previously suggested to have a role in CHD. Subject and method: 932 participants were included, and plasma samples obtained. A quantitative reverse-transcription PCR(RT-qPCR) assay was conducted to confirm the concentration of plasma miRNAs. Circulating levels of miRNAs were quantified using the 2^-Δct method. The severity of coronary atherosclerosis was evaluated via Gensini Scores. Result: The circulating levels of the nine proposed miRNAs were not different among the five main ethnicities examined (all p > 0.05). The Spearman correlation analyses indicated that miR-221 and miR-130a were negatively associated with the severity of CHD as indicated by Gensini Scores (r = -0.106, p = 0.001;r = -0.073, p = 0.026). Results of the univariate analysis showed that lower circulating miR-221 (OR, 1.663; 95 % CI, 1.255-2.202, p = <0.001), miR-155 (OR, 1.520; 95 % CI, 1.132-2.042, p = 0.005), and miR-130a (OR, 1.943; 95% CI, 1.410-2.678, p = <0.001) were potential risk factors for CHD. Moreover, miR-130a (OR, 2.405; 95 % CI, 1.691-3.421, p = <0.001) remained independently associated with the risk of CHD after adjusting for potential confounding factors. The analysis of the possible positive/negative associations between miR-221, miR-155 and miR-130awere conducted. A positive association between miR-130a and miR-155 was found (SI = 1.60, SIM = 1.21 and AP = 0.22), and in these groups, the proportion of CHD attributable to the interaction between miR-130a and miR-155 was as high as 22 %. A negative interaction was found between miR-221 and miR-130a (SI = 0.68, SIM = 0.60 and AP = 0.27). Conclusion: Plasma levels of miR-221, miR-130a and miR-155 decreased in patients with CHD, and miR-130a may be an independent predictor for CHD.

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“…However, just as we found that postnatal exposure to a Western diet unmasked metabolic defects in obese-born mice, 13 so does the dietary challenge unmask changes to the cardiac miRNA pool of obese-born offspring. Whereas these changes were subtle, the downregulation of miR-125, a miRNA implicated in cardiac fibrosis, 14 coronary heart disease risk, 15 and known for its myocardial protective effects in reperfusion injury, was notable. 16 The most significant expression change in response to maternal obesity, upregulation of miR-148-3p, was associated with several cardiac disease pathways as well as ErbB signaling, a pathway critical for both cardiac development and adult heart function.…”

Section: Discussionmentioning

confidence: 99%

Nutrition has a pervasive impact on cardiac microRNA expression in isogenic mice

et al. 2016

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The complex interaction between obesity, Western-style diets, and cardiovascular disease is of increasing interest, with a growing number of children being born to obese parents with poor lifestyle choices. These offspring have themselves an increased susceptibility to obesity and subsequent cardiovascular disease in adult life, which may be 'programmed' by their intrauterine environment. Cardiac microRNAs (miRNAs) are affected by multiple disease states, and have also been shown to be capable of exerting a hormone-like control on whole body metabolism. Here we sought to determine the effect of prenatal exposure to maternal obesity and/or postnatal exposure to a Western diet on miRNA expression in the heart. Unbiased small RNA sequencing was carried out on cardiac tissue from young adult mice born to lean or obese mothers; offspring were weaned onto either a low-fat control diet or a high-fat Western-style diet. We found 8 cardiac miRNAs that were significantly altered in response to maternal obesity, but only when the offspring were challenged postnatally with the Western diet. In contrast, postnatal exposure to the diet alone induced significant changes to the expression of a much larger number of miRNAs (33 in offspring of lean and 46 in offspring of obese). Many of the affected miRNAs have previously been implicated in various cardiac pathologies. The pervasive cardiac miRNA changes induced by a Western diet suggest that an individual's lifestyle choices outweigh the impact of any programming effects by maternal obesity on miRNA-related cardiac health.

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Interaction between microRNA expression and classical risk factors in the risk of coronary heart disease

Cited by 37 publications

References 63 publications

Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes

Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes

Predictive Effects of Circulating miR-221, miR-130a and miR-155 for Coronary Heart Disease: A Multi-Ethnic Study in China

Nutrition has a pervasive impact on cardiac microRNA expression in isogenic mice

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