Interaction between lung cancer cell and myofibroblast influenced by cyclic tensile strain

Huang, Jui Chien; Pan, Huei-Jyuan; Yao, Wei-Yu; Tsao, Yu-Wei; Liao, Wen-Chieh; Wu, Chih-Wei; Tung, Yi-Chung; Lee, Chau‐Hwang

doi:10.1039/c2lc41050h

Cited by 20 publications

(14 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, cyclic strain increased the proliferative ability of and decreased apoptosis in Lewis lung cancer cells [161]. Furthermore, cyclic strain increased expression of alpha-smooth muscle actin in myofibroblasts and their ability to accelerate cancer cell migration [162], which is of significant interest as these cells compose a large part of the tumor stroma also in secondary tumors in bone [163]. Furthermore, responses to cyclic strain are cell type-dependent and could depend on malignant capacity as leiomyoma cells (uterine cancer) exhibit attenuated mechanosensitivity to cyclic strain relative to their healthy counterparts [164].…”

Section: Models Of Applied Mechanical Loadingmentioning

confidence: 99%

Biomechanical forces in the skeleton and their relevance to bone metastasis: Biology and engineering considerations

Lynch

Fischbach

2014

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

Bone metastasis represents the leading cause of breast cancer related-deaths. However, the effect of skeleton-associated biomechanical signals on the initiation, progression, and therapy response of breast cancer bone metastasis is largely unknown. This review seeks to highlight possible functional connections between skeletal mechanical signals and breast cancer bone metastasis and their contribution to clinical outcome. It provides an introduction to the physical and biological signals underlying bone functional adaptation and discusses the modulatory roles of mechanical loading and breast cancer metastasis in this process. Following a definition of biophysical design criteria, in vitro and in vivo approaches from the fields of bone biomechanics and tissue engineering will be reviewed that may be suitable to investigate breast cancer bone metastasis as a function of varied mechano-signaling. Finally, an outlook of future opportunities and challenges associated with this newly emerging field will be provided.

show abstract

Section: Models Of Applied Mechanical Loadingmentioning

confidence: 99%

Biomechanical forces in the skeleton and their relevance to bone metastasis: Biology and engineering considerations

Lynch

Fischbach

2014

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

show abstract

“…Jeon et al [112] demonstrated that the presence of interstitial flow in a microvascular network reduced the extravasation of cancer cells and decreased the permeability of vasculature. By applying cyclic tensile strain on myofibroblasts in a PDMS microdevice, Huang et al [182] showed that tensile strain reduced the ability of the myofibroblast to accelerate cancer cell migration. The effect of cyclic tensile strain is also modulated by IL-1b secreted by other cells in the stroma, which implies the complicated interaction between cancer cells and different stromal cell types in the microenvironment.…”

Section: Metastatic Niche: Modelling Tumour -Stroma Interaction and Mmentioning

confidence: 99%

Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

Tsai

Trubelja

Shen

et al. 2017

J. R. Soc. Interface.

158

133

View full text Add to dashboard Cite

Cancer remains one of the leading causes of death, albeit enormous efforts to cure the disease. To overcome the major challenges in cancer therapy, we need to have a better understanding of the tumour microenvironment (TME), as well as a more effective means to screen anti-cancer drug leads; both can be achieved using advanced technologies, including the emerging tumour-on-a-chip technology. Here, we review the recent development of the tumour-on-a-chip technology, which integrates microfluidics, microfabrication, tissue engineering and biomaterials research, and offers new opportunities for building and applying functional three-dimensional in vitro human tumour models for oncology research, immunotherapy studies and drug screening. In particular, tumour-on-a-chip microdevices allow well-controlled microscopic studies of the interaction among tumour cells, immune cells and cells in the TME, of which simple tissue cultures and animal models are not amenable to do. The challenges in developing the next-generation tumour-on-a-chip technology are also discussed.

show abstract

“…41 In general, on-chip valving methods have been demonstrated as a versatile, quantitative, and high-throughput method in many cell-cell and cell-microenvironment studies. 42–45 …”

Section: Intercellular Population Communicationmentioning

confidence: 99%

Probing cell–cell communication with microfluidic devices

Guo

French

et al. 2013

Lab Chip

View full text Add to dashboard Cite

Cell-cell communication plays an essential role in organismal development and functionality, and communication errors can lead to deleterious effects such as degenerative and autoimmune diseases. However, the intercellular communication network is extremely complex in multicellular organisms making isolation of the functional unit and study of basic mechanisms technically challenging. Despite the level of complexity and many challenges facing researchers in this area, recent development in microfluidic technology allows miniaturized and integrated devices to perform intercellular communication experiments on-chip. Microfluidics have many advantages, including the ability to accurately mimic the chemical, mechanical, and physical cellular microenvironment, precise spatial and temporal control, dynamic characterization, high throughput, scalability and reproducibility. In this Focus article, we highlight some of the recent works and advances in the application of microfluidics to the study of mammalian intercellular communication with particular emphasis on cell contact and soluble factor mediated communication. In addition, we provide some insights into the likely direction of the future developments in this field.

show abstract

Interaction between lung cancer cell and myofibroblast influenced by cyclic tensile strain

Cited by 20 publications

References 26 publications

Biomechanical forces in the skeleton and their relevance to bone metastasis: Biology and engineering considerations

Biomechanical forces in the skeleton and their relevance to bone metastasis: Biology and engineering considerations

Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

Probing cell–cell communication with microfluidic devices

Contact Info

Product

Resources

About