1996
DOI: 10.1677/joe.0.1490519
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Interaction between insulin-like growth factor-I and insulin-like growth factor-binding proteins in TC-1 stromal cells

Abstract: IGF-I and -II play an important role in regulating bone formation. Bone marrow stromal cells, particularly those with osteoblast-like features, may act in concert with osteoblasts to increase IGF-I and -II levels in the bone microenvironment. Local bioavailability of IGFs, however, is modulated by IGF binding proteins (IGFBPs). We have previously demonstrated that murine TC-1 stromal cells constitutively secrete IGF-I and IGFBPs. In the present study, we determined the phenotype of these cells and used them as… Show more

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Cited by 5 publications
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“…We are in the process of determining whether LR3-IGF-I treatment up-regulates IGF expression in these cells. Our results for IGFBP expression in hMS(3-4) cells differ from those reported for the murine marrow stromal cell line, TC-1 (61)(62)(63). In this mouse cell model, IGF-I induced an increase in IGFBP-4 and IGFBP-5 at a posttranscriptional level and an increase in IGFBP-3 at both transcriptional and posttranscriptional levels, underlining the known species differences in the IGF system.…”
Section: Discussioncontrasting
confidence: 99%
“…We are in the process of determining whether LR3-IGF-I treatment up-regulates IGF expression in these cells. Our results for IGFBP expression in hMS(3-4) cells differ from those reported for the murine marrow stromal cell line, TC-1 (61)(62)(63). In this mouse cell model, IGF-I induced an increase in IGFBP-4 and IGFBP-5 at a posttranscriptional level and an increase in IGFBP-3 at both transcriptional and posttranscriptional levels, underlining the known species differences in the IGF system.…”
Section: Discussioncontrasting
confidence: 99%