Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in Brewer's yeast induced pyrexia in mice: An isobolographic study

Bhat, Abdul-Shakoor; Tandan, Surendra K.; Kumar, Dinesh; Krishna, V Rama; Prakash, Vellanki Ravi

doi:10.1016/j.ejphar.2005.01.048

Cited by 11 publications

(7 citation statements)

References 22 publications

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“…Yeast-induced fever leads to an intense inflammatory reaction caused by fester at the injection site, which is the most widely used pathogenic fever model for antipyretic medicines. In accordance with previous observations, an initial temperature fall occurred 2 or 3 h post-injection with values among 0.5~1.5 °C, and then an increase of about 1.0 °C above basal temperature was observed 4 h later, and the fever usually lasted for 9~18 h [28,29,30,31,32]. In the present study, the NCG and MCG rats were sampled in parallel to make all datasets comparable.…”

Section: Discussionsupporting

confidence: 88%

Pharmacokinetic-Pharmacodynamic Modeling to Study the Antipyretic Effect of Qingkailing Injection on Pyrexia Model Rats

et al. 2016

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Qingkailing injection (QKLI) is a modern Chinese medicine preparation derived from a well-known classical formulation, An-Gong-Niu-Huang Wan. Although the clinical efficacy of QKLI has been well defined, its severe adverse drug reactions (ADRs) were extensively increased. Through thorough attempts to reduce ADR rates, it was realized that the effect-based rational use plays the key role in clinical practices. Hence, the pharmacokinetic-pharmacodynamic (PK-PD) model was introduced in the present study, aiming to link the pharmacokinetic profiles with the therapeutic outcomes of QKLI, and subsequently to provide valuable guidelines for the rational use of QKLI in clinical settings. The PK properties of the six dominant ingredients in QKLI were compared between the normal treated group (NTG) and the pyrexia model group (MTG). Rectal temperatures were measured in parallel with blood sampling for NTG, MTG, model control group (MCG), and normal control group (NCG). Baicalin and geniposide exhibited appropriate PK parameters, and were selected as the PK markers to map the antipyretic effect of QKLI. Then, a PK-PD model was constructed upon the bacalin and geniposide plasma concentrations vs. the rectal temperature variation values, by a two-compartment PK model with a Sigmoid E max PD model to explain the time delay between the drug plasma concentration of PK markers and the antipyretic effect after a single dose administration of QKLI. The findings obtained would provide fundamental information to propose a more reasonable dosage regimen and improve the level of individualized drug therapy in clinical settings.

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Section: Discussionsupporting

confidence: 88%

Pharmacokinetic-Pharmacodynamic Modeling to Study the Antipyretic Effect of Qingkailing Injection on Pyrexia Model Rats

et al. 2016

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“…Based on a previous validation test with 20 Wistar rats, we decided to use the 18 th hour as the time point to test the antipyretic effect of our extract, because it is the point at which the pyretic effect has stabilized. Also, the 18 th hour point is the one reported in several other previous studies [10]. As was expected, groups A, B and C, which received brewer's yeast, showed a pyretic effect average of 1.12 o C, which was statistically significant (p<0.05).…”

Section: Discussionsupporting

confidence: 67%

“…In this study, pyrexia was induced with brewer's yeast because it is one of the easiest and more reproducible methods reported in the literature [10]. Based on a previous validation test with 20 Wistar rats, we decided to use the 18 th hour as the time point to test the antipyretic effect of our extract, because it is the point at which the pyretic effect has stabilized.…”

Section: Discussionmentioning

confidence: 99%

Antipyretic effect of the aqueous extract obtained from leaves of Neurolaena lobata (Asteraceae) on a pyretic model induced by brewer's yeast

González

Escalante²,

Oreiro

2007

Rev.Med.UCR

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ResumenNeurolaena lobata es un arbusto propio de las zonas tropicales, que se puede encontrar principalmente en el Caribe y en América Central. De acuerdo con diversas encuestas de TRAMIL, N. lobata se utiliza para la preparación de muchos remedios caseros en diversas culturas indígenas de la zona, para tratar enfermedades que presentan fiebre. Basado en esto, el objetivo principal de este trabajo fue la determinación de la posible actividad anti-pirética de los extractos acuosos de las hojas de N. lobata. Se utilizaron ratas Wistar (n=40), las cuales fueron divididas en 4 grupos de 10 animales cada uno. En tres de los grupos se indujo fiebre por medio de la administración de levadura de cerveza (como agente pirético). La idea del estudio fue comparar el efecto antipirético del extracto acuoso de las hojas de N. lobata con el del acetaminofén, así como también comparar ambos efectos con el producido por el control de agua destilada (placebo). Los tres grupos que recibieron levadura de cerveza experimentaron el efecto pirético esperado (p<0.05), mientras que el grupo al que no se le suministró la levadura, http://www.revistamedica.ucr.ac. 20Revista Médica de la Universidad de Costa Rica. Volumen 1, número 1, artículo 3, septiembre 2007. Rica, 2060 San José, Costa Rica. ® All rights reserved. no mostró ningún efecto. El grupo A recibió agua destilada como placebo (2 ml/animal), el grupo B recibió acetaminofén como tratamiento antipirético (grupo control positivo; 1000 mg/kg), el grupo C recibió el extracto acuoso de las hojas de N. lobata (solución experimental; 2000 mg/kg) y el grupo D no recibió ningún tratamiento (control negativo). El grupo A no mostró ningún efecto antipirético, mientras que los grupos B y C mostraron un efecto antipirético estadísticamente significativo (p<0.05) y en ambos grupos el efecto se observó a los 30 minutos después de la administración. En conclusión, en este estudio se mostró que las hojas de N. lobata en solución acuosa tienen actividad antipirética, por lo que el uso tradicional es validado en ratas. Este extracto puede ser de utilidad parcial como remedio para controlar la fiebre en ausencia de otros medicamentos disponibles. __________________________________________________________________________ Revista electrónica publicada por la Escuela de Medicina de la Universidad de CostaPalabras claves: Neurolaena lobata, antipirético, fiebre, levadura de cerveza, gavilana AbstractNeurolaena lobata is a bush native of the tropics, that can be found mainly in the Caribbean and Central American areas. Based on TRAMIL surveys, N. lobata leaves are used for the preparation of many remedies among the indigenous cultures, to treat several illnesses associated with fever. Based on that, the main objective of this study was to determine whether the aqueous extract of N. lobata leaves has antipyretic activity on an experimental animal system. We used Wistar rats (n=40), which were divided into 4 groups, and fever was induced in 3 of the groups with brewer's yeast. The idea behind the stud...

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“…[39][40][41][42][43] Sakaguchi et al reported that oral administration of the selective iNOS inhibitor 1400W into type II collageninduced arthritis (CIA) mice had no effect on arthritic inflammation or bone destruction. However, the combined administration of 1400W and a COX inhibitor (indomethacin) showed a synergistic ameliorative effect.…”

Section: Apo Promoted Th2 Differentiation Through Downregulation Of Imentioning

confidence: 99%

Anti-inflammatory and Immunomodulatory Properties of 2-Amino-3H-phenoxazin-3-one

Kohno

Miyazaki

Sano

et al. 2008

Biological & Pharmaceutical Bulletin

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Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in Brewer's yeast induced pyrexia in mice: An isobolographic study

Cited by 11 publications

References 22 publications

Pharmacokinetic-Pharmacodynamic Modeling to Study the Antipyretic Effect of Qingkailing Injection on Pyrexia Model Rats

Pharmacokinetic-Pharmacodynamic Modeling to Study the Antipyretic Effect of Qingkailing Injection on Pyrexia Model Rats

Antipyretic effect of the aqueous extract obtained from leaves of Neurolaena lobata (Asteraceae) on a pyretic model induced by brewer's yeast

Anti-inflammatory and Immunomodulatory Properties of 2-Amino-3H-phenoxazin-3-one

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