“…Although biochemical regulation of the K ATP channel function is incompletely understood, particularly in the brain, a number of post-translational modifications have been reported. For example, SUR2 is affected directly by glycosylation, sulfhydration, and protein kinase A phosphorylation (Gade, et al, 2013,Gao, et al, 2014,Kang, et al, 2014,Light, 1996). The K ATP channel is also regulated via separate phosphorylation event(s) in the Kir6.x channels (Edwards, et al, 2009,Ko, et al, 2008,Sanada and Kitakaze, 2004,Sun, et al, 2008), again showing complex functional interdependence of these proteins.…”