Interaction between homocysteine and lipoprotein(a) increases the prevalence of coronary artery disease/myocardial infarction in women: A case-control study

Balogh, Emília; Bereczky, Zsuzsanna; Katona, Éva; Kőszegi, Zsolt; Édes, István; Muszbek, László; Czuriga, István

doi:10.1016/j.thromres.2011.07.001

Cited by 22 publications

(14 citation statements)

References 37 publications

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“…The thiol group of this molecule favors LDL modification and predisposes to ox-LDL generation [9]. Our data are in accordance with findings from other authors, which suggest that hyperhomocysteinemia is a risk factor for increased ox-LDL levels [9,38,39]. On the other hand, Koubaa et al [39] did not find any difference in ox-LDL levels among Tunisian carriers of the C677T variant allele.…”

Section: Discussionsupporting

confidence: 92%

The MTHFR C677T Polymorphism Is Related to Plasma Concentration of Oxidized Low-Density Lipoprotein in Adolescents with Cardiovascular Risk Factors

Morais¹,

Alves²,

Augusto³

et al. 2015

Lifestyle Genomics

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Aim: The aim of this study was to investigate possible relationships among the A1298C (rs1801131) and C677T (rs1801133) polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and levels of homocysteine, vitamins B₆, B₁₂, folic acid and lipid profile, including oxidized low-density lipoprotein (ox-LDL), of adolescents at cardiovascular risk. Methods: We recruited 115 adolescents (10-19 years old), 58.3% (n = 67) female, from a public school in Brazil who underwent anthropometric, biochemical and genetic tests as well as food consumption evaluation. Results: An important prevalence of hyperhomocysteinemia (19.1%) and alterations in triacylglycerol (17.4%), total cholesterol (26.9%) and high-density lipoprotein (HDL) cholesterol (48.0%) concentrations were observed, as well as low vitamin B₆ concentrations (23.5%). The categorization of homocysteine concentrations into tertiles revealed significant differences in serum concentrations of folate, vitamin B₁₂ and HDL, waist circumference and intake of total and saturated fat among the tertiles. The presence of variant alleles regarding the MTHFR C677T polymorphism interfered with vitamin B₆ and ox-LDL cholesterol concentrations. There was a trend for higher waist circumference values in T carriers (C677T), but not in C carriers (A1298C). Conclusions: The MTHFR C677T allele was associated with higher plasma vitamin B₆ and ox-LDL compared to the CC genotype.

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Section: Discussionsupporting

confidence: 92%

The MTHFR C677T Polymorphism Is Related to Plasma Concentration of Oxidized Low-Density Lipoprotein in Adolescents with Cardiovascular Risk Factors

Morais¹,

Alves²,

Augusto³

et al. 2015

Lifestyle Genomics

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“…In this population the frequency of the TT genotype was more common among patients with coronary artery disease than the control group (Li 2012). Regardless of the results of recent meta-analyses, the role of the C677T polymorphism in the etiopathology of coronary artery disease and myocardial infarction is still controversial, and it has not been observed in some populations (Balogh et al 2012; Iqbal et al 2005). This discrepancy may be related to differences in genetic background in the populations studied or to differences in the selection of patients and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Genetic Polymorphisms and the Risk of Myocardial Infarction in Patients Under 45 Years of Age

et al. 2012

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This study investigates the potential role of 17 chosen polymorphisms in 15 candidate genes and the risk of myocardial infarction in patients under 45 years of age. The study consists of 271 patients with myocardial infarction and 141 controls. The analysis of genetic polymorphisms was performed using the PCR–RFLP method. Of the chosen polymorphisms, two (Leu125Val PECAM1 and A1/A2 FVII) are related to myocardial infarction and two (C677T MTHFR and 5A/6A MMP3) to advanced stenosis in arterial vessels (> 75%). We also found that the frequency of some combinations among the analyzed genes and environmental factors varied between the patient and control groups.

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“…Numerous studies have investigated this association among different populations and have noted similar findings (38)(39)(40)(41)(42)(43). Other studies suggest a significant association of C677T MTHFR with MI risk (30,37,44,45).…”

Section: ------------------------------------------------------------mentioning

confidence: 63%

Association of C677T MTHFR and G20210A FII prothrombin polymorphisms with susceptibility to myocardial infarction

et al. 2016

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Abstract. Myocardial infarction (MI) is a common complex pathology, localized in the main leading causes of mortality worldwide. It is the result of the interaction of genetic and environmental factors. The aim of the present study was to investigate the potential association of C677T 5,10-methylenetetrahydrofolate reductase (MTHFR) (rs1801133) and G20210A factor II prothrombin (FII) (rs1799963) polymorphisms with the susceptibility of MI. Following extraction by the standard salting-out procedure, DNA samples of 100 MI patients and 182 apparently healthy controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism using Hinf I and HindIII restriction enzymes, respectively. The results show a significant association of the G20210T FII polymorphism with the MI risk. The frequencies of the heterozygote genotype GA, homozygous mutated AA and the G20210A allele was higher among patients compared to controls (GA: 59 vs. 5.5%, P<0.001; AA: 10 vs. 0%, P=0.003; and 20210A: 39.5 vs. 2.7%, P<0.003), suggesting that this polymorphism may be a potential genetic marker for MI. No significant association was observed between the C677T MTHFR and MI occurrence, and there was more heterozygote CT in the patient group compared to the controls. As a multifactorial disease, the development of MI may be the result of numerous factors that influence synergistically its occurrence.Thus, further studies are merited to try to better assess these associations (gene-gene and gene-environment interactions).

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Interaction between homocysteine and lipoprotein(a) increases the prevalence of coronary artery disease/myocardial infarction in women: A case-control study

Cited by 22 publications

References 37 publications

The <b><i>MTHFR</i></b> C677T Polymorphism Is Related to Plasma Concentration of Oxidized Low-Density Lipoprotein in Adolescents with Cardiovascular Risk Factors

The <b><i>MTHFR</i></b> C677T Polymorphism Is Related to Plasma Concentration of Oxidized Low-Density Lipoprotein in Adolescents with Cardiovascular Risk Factors

Genetic Polymorphisms and the Risk of Myocardial Infarction in Patients Under 45 Years of Age

Association of C677T MTHFR and G20210A FII prothrombin polymorphisms with susceptibility to myocardial infarction

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