Interaction between HLA-B60 and HLA-B27 as a Better Predictor of Ankylosing Spondylitis in a Taiwanese Population

Wei, James Cheng‐Chung; Sung-Ching, Henry Wong; Hsu, Yu Wen; Wen, Ya Feng; Wang, Wen Chang; Wong, Roderick; Lu, Hsing Fang; Gaalen, Floris A van; Chang, Wei‐Chiao

doi:10.1371/journal.pone.0137189

Cited by 24 publications

(26 citation statements)

References 23 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…, B27-positive/B40:01-positive has RR of 342 (147-708) 101 . Results in a Taiwanese cohort are similar 100 . na, confidence interval not available…”

Section: Tolerance Inductionsupporting

confidence: 56%

“…This epistatic (gene/gene) interaction suggests that ERAP1 contributes to disease susceptibility by exacerbating the pathogenic role of HLA-B*27. Another epistatic interaction results in a greater risk for developing AS in patients heterozygous for two HLA class I risk alleles (HLA-B*27 and HLA-B*40:01, the latter encoding the Bw60 serotype) than would be expected from the additive effect of the two alleles on disease risk 100,101 .…”

Section: [H1] Mechanisms Of Hla Disease Associationsmentioning

confidence: 99%

See 1 more Smart Citation

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications

2019

View full text Add to dashboard Cite

Our understanding of the mechanisms underlying HLA associations with inflammatory arthritis continues to evolve. Disease associations have been refined, and interactions of HLA genotype with other genes and environmental risk factors in determining disease risk have been identified. This Review provides basic information on the genetics and molecular function of HLA molecules, as well as general features of HLA associations with disease. We summarise evidence for various peptidedependent and peptide-independent mechanisms by which HLA alleles might contribute to the pathogenesis of three types of inflammatory arthritis: rheumatoid arthritis, spondyloarthritis and systemic juvenile idiopathic arthritis. Also discussed are HLA allelic associations that shed light on the genetic heterogeneity of inflammatory arthritides and on the relationships between adult and pediatric forms of arthritis. Clinical implications range from improved diagnosis and outcome prediction to the possibility of using HLA associations in developing personalized strategies for the treatment and prevention of these diseases. [ED: Some general editorial comments are replied to in the marginal comments. For replies to reviewers, please see the accompanying file.]

show abstract

“…, B27-positive/B40:01-positive has RR of 342 (147-708) 101 . Results in a Taiwanese cohort are similar 100 . na, confidence interval not available…”

Section: Tolerance Inductionsupporting

confidence: 56%

Section: [H1] Mechanisms Of Hla Disease Associationsmentioning

confidence: 99%

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications

2019

View full text Add to dashboard Cite

show abstract

“…Further, psoriatic patients with arthritis were more likely to develop severe vascular complications (cardiovascular diseases) than those without. The frequency of HLA‐B27 in Taiwanese subjects was 7.7% …”

Section: Psoriatic Arthritis In Eastern Asiamentioning

confidence: 99%

Clinical characteristics of Japanese patients with psoriatic arthritis: Comparison with East Asian countries

Yamamoto

Kawada

2017

The Journal of Dermatology

View full text Add to dashboard Cite

To determine the characteristics and current status of Japanese patients with psoriatic arthritis, the Japanese Society for Psoriasis Research have started to conduct retrospective questionnaire surveys. The results collected from over a thousand patients with psoriatic arthritis have revealed several characteristics. The newly visited psoriatic arthritis patients accounted for approximately 10% of all new psoriatic patients who visited the dermatology department in many referral centers. The prevalence was nearly 15% of psoriatic patients, which was similar to a recent rheumatology and dermatology study in Japan with a large cohort. There was a male predominance. The mean age of onset for cutaneous psoriasis was in the late 30s, while that of arthritis was in the late 40s. If we compare the precedence of cutaneous psoriasis versus arthritis, the psoriasis precedent group accounted for nearly 75%, while arthritis accounted for 5% of cases. The mean duration in patients who developed psoriasis prior to arthritis was over 10 years, while that in patients preceded by arthritis was less than 5 years. According to the Moll and Wright criteria, polyarthritis type was most common, followed by distal interphalangeal type and oligoarthritis type. Biologics were used in over 50% of psoriatic arthritis patients, and TNF inhibitors were currently used in approximately 70% among biologics. Switching to other biologics or discontinuance was seen in 15%. This review shows the current status of psoriatic arthritis in Japan, as well as a comparison of the prevalence among East Asian countries.

show abstract

“…Studies of the contribution of major histocompatibility complex (MHC)-encoded variants to the heritability of ankylosing spondylitis (AS) suggest that it is responsible for 20.44% of the genetic risk for the disease, with over 114 non-MHC variants identified to date contributing another 7.38% 1. Other MHC region genes have also been implicated in addition to HLA-B*27 , including HLA-B*14 ,2 3 HLA-B*60 ,4–8 HLA-DRB1, 9–11 HLA-DPB1, 11 12 MICA ,13 14 TNF-alpha1 ,15 TAP1 16 and LMP2, 11 17 although the level of association of these findings has not been definitive and with the exception of HLA-B*60 replication has not been universal.…”

Section: Introductionmentioning

confidence: 99%

HLA class I and II alleles in susceptibility to ankylosing spondylitis

et al. 2018

View full text Add to dashboard Cite

ObjectiveTo examine associations of HLA class I and class II alleles with ankylosing spondylitis (AS) in three cohorts of patients of European, Asian and African ancestry.MethodsHLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1 and HLA-DPB1 alleles were genotyped in 1948 unrelated white and 67 African-American patients with AS from the Prospective Study of Outcomes in Ankylosing Spondylitis cohort, the North American Spondylitis Consortium and Australo-Anglo-American Spondyloarthritis Consortium, 990 white and 245 African-American Controls and HLA-B alleles in 442 Han Chinese patients with AS and 346 controls from Shanghai and Gansu, China. In addition to the case:control analyses, HLA-B*27-negative patients with AS were analysed separately, and logistic regression and ‘relative predispositional effects’ (RPE) analyses were carried out to control for the major effect of HLA-B*27 on disease susceptibility.ResultsAlthough numerous associations were seen between HLA alleles and AS in whites, among HLA-B*27-negative patients with AS , positive associations were seen with HLA-A*29, B*38, B*49, B*52, DRB1*11 and DPB1*03:01 and negative associations with HLA-B*07, HLA-B*57, HLA-DRB1*15:01, HLA-DQB1*02:01 and HLA -DQB1*06:02. Additional associations with HLA-B*14 and B*40 (B60) were observed via RPE analysis, which excludes the HLA-B*27 alleles. The increased frequency of HLA-B*40:01 and decreased frequency of HLA-B*07 was also seen in Han Chinese and African-Americans with AS. HLA-B*08 was decreased in whites with acute anterior uveitis.ConclusionsThese data, analysing the largest number of patients with AS examined to date in three ethnic groups, confirm that other HLA class I and II alleles other than HLA-B*27 to be operative in AS predisposition.

show abstract

Interaction between HLA-B60 and HLA-B27 as a Better Predictor of Ankylosing Spondylitis in a Taiwanese Population

Cited by 24 publications

References 23 publications

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications

Clinical characteristics of Japanese patients with psoriatic arthritis: Comparison with East Asian countries

HLA class I and II alleles in susceptibility to ankylosing spondylitis

Contact Info

Product

Resources

About