Interaction between histamine and monoamine oxidase inhibitors

Abstract

The monoamine oxidase inhibitors tranylcypromine, nialamide and iproniazid potentiated the actions of histamine on the blood pressure of the cat and on the tracheo‐bronchial muscle of the guinea‐pig. These findings may have relevance to side‐effects of treatment with monoamine oxidase inhibitors.

Drug interaction in anaesthesia a review

“…For a base, per cent ionization -1 + anti log (pH -pKa) 100 For an acid, per cent ionization = 1 + anti log (pKa -pH)…”