Interaction between Her2 and Beclin-1 Proteins Underlies a New Mechanism of Reciprocal Regulation

Han, Jie; Hou, Wen Chi; Lu, Chang; Goldstein, Leslie A.; Stolz, Donna B.; Watkins, Simon C.; Rabinowich, Hannah

doi:10.1074/jbc.m113.461350

Cited by 47 publications

(50 citation statements)

References 50 publications

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“…Beclin 1 was also associated with HER-2, an important biomarker of breast cancer, in a breast cancer microarray dataset analysis; there was a significant association between the loss of Beclin 1 and HER-2 amplification [95]. Of note, Beclin 1 interacts with HER-2 resulting in increased phosphorylation of HER-2 [96]. In breast cancer, other than its role as tumor suppressor and tumor supporter, Beclin 1 is also involved in drug resistance.…”

Section: Expression Of Beclin 1 In Human Breast Cancersmentioning

confidence: 90%

The potential of Beclin 1 as a therapeutic target for the treatment of breast cancer

Jung

Lee

Koo

2015

Expert Opinion on Therapeutic Targets

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Because Beclin 1 is expressed in breast cancer cells, Beclin 1 could be a unique, effective drug target for the prevention and treatment of breast cancer. However, the expression of Beclin 1 varies according to cancer molecular subtypes, and Beclin 1 is involved in both breast cancer suppression and tumor progression; therefore, the decision of using a Beclin 1 inducer or inhibitor should be made based on breast cancer stage and subtype.

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Section: Expression Of Beclin 1 In Human Breast Cancersmentioning

confidence: 90%

The potential of Beclin 1 as a therapeutic target for the treatment of breast cancer

Jung

Lee

Koo

2015

Expert Opinion on Therapeutic Targets

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“…Consistent, lapatinib activates autophagy in breast cancer cells [67] and leukemic cells [68], whereas this has not been reported for trastuzumab. Second, recent work has revealed that HER-2 physically interacts with Beclin 1 in breast cancer cells, although the biological significance of this interaction is unclear [69]. …”

Section: Tyrosine Kinase Inhibitorsmentioning

confidence: 99%

Cardiomyocyte autophagy and cancer chemotherapy

Hill

2014

Journal of Molecular and Cellular Cardiology

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Autophagy, an evolutionally conserved process of controlled cellular cannibalization, plays a vital role in cardiac physiology. Perturbations in cardiomyocyte autophagy contribute to the pathogenesis of a wide range of cardiac diseases, many of which culminate in heart failure. With recent advances in cancer chemotherapy and consequent improvements in cancer survival, drug-induced toxicity to the heart has assumed greater importance. As a number of prominent cellular pathways are critical to the survival of both tumor cells and heart cells, it comes as little surprise that therapies targeting those pathways have consequences in both tissues. Little is known presently about cardiomyocyte autophagy, a prominent cellular response to stress, in the setting of chemotherapy, but preliminary evidence suggests an important and context-dependent role. Dissecting the role of autophagy in “onco-cardiology” will likely yield insights into mechanisms underlying cardiomyopathy and may lead to novel means to protect the myocardium from chemotherapy-induced injury.

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“…Blasticidin selected clones with verified Tet repressor expression were further stably transfected with the linearized Tetinducible plasmids pcDNA4/TO, pcDNA4/TO/lacZ (Invitrogen), or pcDNA4/TO/C325A caspase-9. All procedures involving linearization, transfection, and stable clone selection were carried out as described previously (41)(42)(43).…”

Section: Methodsmentioning

confidence: 99%

A Complex between Atg7 and Caspase-9

Han

Hou

Goldstein

et al. 2014

Journal of Biological Chemistry

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Background: Several cross-talk mechanisms between autophagy and apoptosis have been identified, where the same protein plays a central role in the opposing processes. Results: This study identified a novel cross-talk mechanism involving an Atg7⅐caspase-9 complex. Conclusion: Atg7 and caspase-9 mutually regulate each other's activity. Significance: The Atg7⅐caspase-9 complex may determine the balance between autophagy and apoptosis in response to stress.

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Interaction between Her2 and Beclin-1 Proteins Underlies a New Mechanism of Reciprocal Regulation

Cited by 47 publications

References 50 publications

The potential of Beclin 1 as a therapeutic target for the treatment of breast cancer

The potential of Beclin 1 as a therapeutic target for the treatment of breast cancer

Cardiomyocyte autophagy and cancer chemotherapy

A Complex between Atg7 and Caspase-9

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