Interaction between haemochromatosis and transferrin receptor genes in different neoplastic disorders

Beckman, L.; Landeghem, G. F. Van; Síkström, C.; Wåhlin, Anders; Markevärn, Berit; Hallmans, Göran; Lenner, Per; Athlin, L.; Stenling, Roger

doi:10.1093/carcin/20.7.1231

Cited by 83 publications

(68 citation statements)

References 29 publications

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“…Since then, results of in vitro studies and in vivo interventions in laboratory animals have consistently supported this theory (89)(90)(91)(92)(93)(94)(95). What is more, evidence surrounding patients with hemochromatosis has proven that the overload iron status, characteristic of this pathology, can also be a risk factor for several cancer types such as liver, colorectal, and breast (96).…”

Section: General Overviewmentioning

confidence: 95%

Iron and Cancer Risk—A Systematic Review and Meta-analysis of the Epidemiological Evidence

Fonseca-Nunes

Jakszyn

Agudo

2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

266

181

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Iron has been suggested as a risk factor for different types of cancers mainly due to its prooxidant activity, which can lead to oxidative DNA damage. Furthermore, subjects with hemochromatosis or iron overload have been shown to have a higher risk of developing liver cancer. We have systematically reviewed 59 epidemiologic studies, published between 1995 and 2012, reporting information on total iron, dietary iron, heme iron, and biomarkers of iron status and cancer risk. Furthermore we conducted metaanalysis for colorectal [relative risk (RR), 1.08; 95% confidence interval (CI), 1.00-1.17], colon (RR ¼ 1.12; 95% CI, 1.03-1.22), breast (RR ¼ 1.03; 95% CI, 0.97-1.09), and lung cancer (RR ¼ 1.12; 95% CI, 0.98-1.29), for an increase of 1 mg/day of heme iron intake. Globally, on the basis of the systematic review and the metaanalysis results, a higher intake of heme iron has shown a tendency toward a positive association with cancer risk. Evidence regarding high levels of biomarkers of iron stores (mostly with serum ferritin) suggests a negative effect toward cancer risk. More prospective studies combining research on dietary iron intake, iron biomarkers, genetic susceptibility, and other relevant factors need to be conducted to clarify these findings and better understand the role of iron in cancer development. Cancer Epidemiol Biomarkers Prev; 23(1); 12-31. Ó2013 AACR.

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Section: General Overviewmentioning

confidence: 95%

Iron and Cancer Risk—A Systematic Review and Meta-analysis of the Epidemiological Evidence

Fonseca-Nunes

Jakszyn

Agudo

2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

266

181

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“…Transferrin receptor (TFR) is also a key element of the regulation of iron homeostasis. The S142G variant of TFR was reported to influence cancer susceptibility (colon, breast, myeloma) in combination with distinct HFE genotypes (13). The effects of iron homeostasis, and HFE and TFR genotypes were extensively studied in several solid tumors even in large patient cohorts (7)(8)(9)(10)(11)(12)(14)(15)(16)(17)(18)), but only a few studies with small patient cohorts tested the potential role of HFE in chronic myeloproliferative disorders (CMPD), a clonal disorder of the main iron using tissue of the body (19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

HFEC282Y Mutation as a Genetic Modifier Influencing Disease Susceptibility for Chronic Myeloproliferative Disease

Andrikovics

Meggyesi

Szilvási

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Iron metabolism has been implicated in carcinogenesis and several studies assessed the potential role of genetic variants of proteins involved in iron metabolism (HFE C282Y, TFR S142G) in different malignancies. Few reports addressed this issue with relation to chronic myeloproliferative disorders (CMPD). The aims of our study were (a) to examine the potential associations of CMPD development with genetic modifiers of iron metabolism in a large cohort of CMPD patients; (b) to examine associations of genetic variants of proteins involved in iron metabolism; and acquired JAK2 V617F mutation with clinical characteristics of CMPD. HFE C282Y was genotyped in 328 CMPD patients and 996 blood donors as controls, HFE H63D, and TFR S142G were tested in CMPD patients and 171 first time blood donors. JAK2 V617F mutation was tested in CMPD patients and in 122 repeated blood donors. Decreased C282Y allele frequency (allele frequency F 95% confidence interval) was found in the CMPD group (1.8% F 1.0%) compared with controls (3.4% F 0.8%; P = 0.048). TFR S142G allele frequency was reduced among V617F-negative CMPD patients (34.8% F7.6%) compared with controls (47.8% F 5.4%; P = 0.02). The frequency of JAK2 V617F was 75.9% (249 of 328) in the CMPD group. At presentation, elevated hemoglobin levels were found in V617F-positive patients compared with V617F-negative counterparts (P < 0.000). Vascular complications (26.6% versus 15.2%; P = 0.039) as well as female gender (57.4% versus 41.8%; P = 0.019) were more common in V617F-positive patients. We found that HFE C282Y might be associated with a protective role against CMPD. Because chronic iron deficiency or latent anemia may trigger disease susceptibility for CMPD, HFE C282Y positivity may be a genetic factor influencing this effect. (Cancer Epidemiol Biomarkers Prev 2009;18(3):929 -34)

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“…Iron deficiency negatively affects the immune system 16 , thyroid metabolism 17 and cognitive functions 18 . On the other hand, iron surplus is related to various pathological conditions such as cancer 19 , neurodegenerative diseases 20 , and damage of liver 21 and testicles 22 . Therefore, while keeping the serum iron levels and other iron parameters within a certain interval is important for body function, various complicated mechanisms take part in the establishment of this balance.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the mobile phone electromagnetic radiation on serum iron parameters in rats

et al. 2017

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Background: Electromagnetic fields (EMF) created by mobile phones during communication have harmful effects on different organs. Objectives: It was aimed to investigate the effects of an EMF created by a mobile phone on serum iron level, ferritin, unsaturated iron binding capacity and total iron binding capacity within a rat experiment model. Methods: A total of 32 male Wistar albino rats were randomly divided into the control, sham, mobile phone speech (2h/day) and stand by (12 h/day) groups. The speech and stand by groups were subjected to the EMF for a total of 10 weeks. Results: No statistically significant difference was observed between the serum iron and ferritin values of the rats in the speech and stand by groups than the control and sham groups (p>0.05). The unsaturated iron binding capacity and total iron capacity values of the rats in the speech and stand by groups were significantly lower in comparison to the control group (p<0.01). Conclusion: It was found that exposure to EMF created by mobile phones affected unsaturated iron binding capacity and total iron binding capacity negatively.

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Interaction between haemochromatosis and transferrin receptor genes in different neoplastic disorders

Cited by 83 publications

References 29 publications

Iron and Cancer Risk—A Systematic Review and Meta-analysis of the Epidemiological Evidence

Iron and Cancer Risk—A Systematic Review and Meta-analysis of the Epidemiological Evidence

HFEC282Y Mutation as a Genetic Modifier Influencing Disease Susceptibility for Chronic Myeloproliferative Disease

Evaluation of the mobile phone electromagnetic radiation on serum iron parameters in rats

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