Interaction between flavonoid, quercetin and surfactant aggregates with different charges

Liu, Weiya; Guo, Rong

doi:10.1016/j.jcis.2006.06.045

Cited by 85 publications

(62 citation statements)

References 23 publications

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“…The values of a and n were calculated to be 0.497 and 1.8, respectively, suggesting that two electrons were involved in the oxidation process. This was in according with that reported in the literature [36].…”

Section: Influence Of Potential Scan Ratessupporting

confidence: 92%

Voltammetric behavior and the determination of quercetin at a flowerlike Co3O4 nanoparticles modified glassy carbon electrode

et al. 2010

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Flowerlike Co 3 O 4 nanoparticles were used as a modifier on the glassy carbon electrode to fabricate a quercetin (Qu) sensor. The morphology and crystallinity of the prepared Co 3 O 4 material were investigated by scanning electron microscopy and X-ray diffraction. Electrochemical behavior of Qu at the sensor was studied by cyclic voltammetry and semi-derivative voltammetry. Results suggested that the modified electrode exhibited a strong electrocatalytic activity toward the redox of Qu. The electron transfer coefficient (a), the number of electron transfer (n), and the diffusion coefficient (D) of Qu at the sensor were calculated. Under the optimum conditions, the catalytic peak currents of Qu were linearly dependent on the concentrations of Qu in the range from 5.0 9 10 -7 to 3.3 9 10 -4 M, with a detection limit of 1.0 9 10 -7 M. This proposed method was successfully applied to determine the quercetin concentration in Ginkgo leaf tablet and human urine samples.

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Section: Influence Of Potential Scan Ratessupporting

confidence: 92%

Voltammetric behavior and the determination of quercetin at a flowerlike Co3O4 nanoparticles modified glassy carbon electrode

et al. 2010

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“…N-unsubstituted sulfenamides showed feebler signals and spectral shifts than the corresponding substituted derivatives, suggesting a stronger interaction of the latter with the membrane mimetic system. All sulfenamides studied present (Table 2), indicating a high affinity toward hydrophobic media with anionic character, and suggesting a general good membrane permeation capability [14,16,27,28]. N-substituted benzothiazolyl sulfenamides 2-5 showed higher partition coefficients than the unsubstituted one (1), with values ranging from 0.4 Â 10 4 to 3.8 Â 10…”

Section: Resultsmentioning

confidence: 96%

“…This procedure was used in this study to quantify the interaction of the new sulfenamides with sodium dodecyl sulfate (SDS) micellar aggregates and to evaluate the partition coefficients, K p, compiled in Table 2. Partition coefficients toward sodium dodecyl sulfate micelles [14,27,32,33] were determined under the same experimental conditions as for the enzymatic assays (solvent mixture and buffer). To ensure the reliability of the K p values obtained, Sparc online calculator v4.2, was used to evaluate pKa for all compounds, showing that they are all unionized at pH ¼ 8.…”

Section: Resultsmentioning

confidence: 99%

“…Partition coefficients toward sodium dodecyl sulfate micelles were determined resorting to second derivative spectrophotometry studies [30,31] under the same conditions of the biological assays. The changes in the absorption spectrum of solutes associated with the presence of micellar aggregates allow the discrimination between molecules in the different solubilization environments enabling the quantification of free or micelle-bound solute, whenever solute micellar binding/incorporation is accompanied by appropriate spectral shifts [14,27]. Sodium dodecyl sulfate critical micelle concentration (CMC) in the presence of MeOH (3%), and Tris buffer was determined through surface tension measurements, using a titrimetric procedure, and resorting to Gibbs equation (CMC ¼ 1.23 Â 10 À3 M) [32,36,[39][40][41].…”

Section: Methodsmentioning

confidence: 99%

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Novel sulfenamides as promising acetylcholinesterase inhibitors

Proença

Serralheiro

Araújo

et al. 2011

Journal of Heterocyclic Chem

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Several sulfenamide derivatives were designed as possible acetylcholinesterase (AChE) inhibitors. New sulfenamides were synthesized and proved to be stable under the physiological conditions used in the enzymatic assays. N‐benzyl‐2‐benzoxazolylsulfenamide (8) and N‐benzyl‐2‐benzimidazolylsulfenamide (9) revealed anti‐AChE activity with IC50 values of 0.6 and 0.8 μM, respectively, values of the same magnitude as those reported for galantamine and tacrine. The affinity for the biological site was evaluated in terms of interaction/partition toward sodium dodecyl sulfate (SDS) micelles. The inhibitory activity profiles were reasoned in terms of both partition toward a hydrophobic anionic environment and molecular geometry. The XCSN dihedral angle deviations from collinearity stood out as a major parameter linked to enzyme specificity. J. Heterocyclic Chem., (2011).

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“…Since a direct in vivo study is difficult, many works have used biologicallymimicking systems such as the AOT reverse micelle and hydro-organic mixed solvents. [15][16][17][18][19] Surfactants dissolved in nonpolar solvents assemble to form reverse micelles. In this system, the polar head groups of amphiphiles aggregate to form a micellar core and the hydrophobic tails extend into the bulk solvent.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic Properties of Quercetin in AOT Reverse Micelles

Park¹,

Im²,

Seo³

et al. 2014

Bulletin of the Korean Chemical Society

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The spectroscopic properties of quercetin (QCT) were studied in the AOT reverse micelle by fluorescence spectroscopy. Because the molecular structure of QCT is completely planar, excited state intramolecular proton transfer (ESIPT) occurs between the -OH at C(5) and carbonyl oxygen via intramolecular hydrogen bonding. This ESIPT happens at the S1 state but not at the S2 state. Because QCT is a good donor-acceptor-conjugated molecule at the excited state, this molecule can emit strong fluorescence but shows no S1 → So emission due to this ESIPT. Since the S2 → S1 internal conversion was very slow due to the small Franck-Condon factors, S2 → So fluorescence emission was observed. All of the experimental results indicated that the QCT resided at the bound water interface and that the position of solute did not change significantly in the micelle at various water concentrations.

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Interaction between flavonoid, quercetin and surfactant aggregates with different charges

Cited by 85 publications

References 23 publications

Voltammetric behavior and the determination of quercetin at a flowerlike Co3O4 nanoparticles modified glassy carbon electrode

Voltammetric behavior and the determination of quercetin at a flowerlike Co3O4 nanoparticles modified glassy carbon electrode

Novel sulfenamides as promising acetylcholinesterase inhibitors

Spectroscopic Properties of Quercetin in AOT Reverse Micelles

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