Interaction between Diclofenac and Soil Humic Acids

Margon, Alja; Pastrello, Arnold; Mosetti, Davide; Cantone, Pierpaolo; Leita, L.

doi:10.1080/15320380902962353

Cited by 8 publications

(7 citation statements)

References 28 publications

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“…It thus appears that SPME provides a tool to characterize the dynamic features of organic chemicals in the presence of sorbing NPs. However, in natural systems, the behavior of trace organics such as pharmaceuticals could be involved: metabolites and transformation products may have sorption behavior different from that of the parent compound and may bind to a variety of sorbents in aquatic systems. , Each associate will exhibit its own particular kinetic features, and thus a differentiated approach may be required to characterize the chemodynamic features and correctly quantify the fate and reactivity of organic targets in natural waters.…”

Section: Discussionmentioning

confidence: 99%

Speciation Analysis of Aqueous Nanoparticulate Diclofenac Complexes by Solid-Phase Microextraction

et al. 2012

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The dynamic sorption of an organic compound by nanoparticles (NPs) is analyzed by solid-phase microextraction (SPME) for the example case of the pharmaceutical diclofenac in dispersions of impermeable (silica, SiO(2)) and permeable (bovine serum albumin, BSA) NPs. It is shown that only the protonated neutral form of diclofenac is accumulated in the solid phase, and hence this species governs the eventual partition equilibrium. On the other hand, the rate of the solid/water partition equilibration is enhanced in the presence of the sorbing nanoparticles of SiO(2) and BSA. This feature demonstrates that the NPs themselves do not enter the solid phase to any appreciable extent. The enhanced rate of attainment of equilibrium is due to a shuttle-type of contribution from the NP-species to the diffusive supply of diclofenac to the water/solid interface. For both types of nanoparticulate complexes, the rate constant for desorption (k(des)) of bound diclofenac was derived from the measured thermodynamic affinity constant and a diffusion-limited rate of adsorption. The computed k(des) values were found to be sufficiently high to render the NP-bound species labile on the effective time scale of SPME. In agreement with theoretical prediction, the experimental results are quantitatively described by fully labile behavior of the diclofenac/nanoparticle system and an ensuing accumulation rate controlled by the coupled diffusion of neutral, deprotonated, and NP-bound diclofenac species.

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Section: Discussionmentioning

confidence: 99%

Speciation Analysis of Aqueous Nanoparticulate Diclofenac Complexes by Solid-Phase Microextraction

et al. 2012

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“…On the other hand, hydrophobic interactions can play an important role in the adsorption of some drugs in dependence on their structure [1,35]. Földényi et al [18] obtained isotherms with a breaking point resulting in the hypothesis of two adsorption steps: the first step related to the charge transfer interaction and the second one related to hydrogen bond formation.…”

Section: Resultsmentioning

confidence: 99%

“…They stated that the number of moles of drug preparations capable of interacting with a natural humic macro-molecule was determined by their molecular structure peculiarities and charges. Margon et al [18] investigated interactions of diclofenac with soil humic acids and resulted that they may led to the formation of diclofenac-humic supramolecules and micelles which can migrate through the coarse soil profile.…”

Section: Introductionmentioning

confidence: 99%

Immobilization of Pharmaceuticals in Soils

Klučáková

2020

NANOCON Conference Proeedings

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Worldwide production and consumption of pharmaceuticals increases every year. Due to the fact that these substances are not always completely eliminated in the human or animal body, subsequently get into the environment, which leads to a negative effect of certain constituents of natural ecosystems. Knowledge of contaminant behaviour is essential for their mobility and toxicity in the soils and surface-and ground-water environments. In this study, interactions of pharmaceuticals with soils and humic substances as the most important constituents of soil organic matter are investigated. Humic substances contain more types of active sites (hydrophilic functional groups and hydrophobic structures) able to bind different drugs and form relatively stable complexes with them. The complexation of drugs with soil organic matter thus can reduce their mobility and toxicity in natural systems. This study deals with interactions of soils and humic substances with drugs. the aim is to determine their binding capacity and stability of formed complexes with respect to the possible immobilization of drugs in the humic structure.

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“…However, few studies have investigated the interaction between organic matter (OM) and pharmaceutical agents such as diclofenac [20], sulfamethazine [21], and tetracyclines [16,22] and polycyclic aromatic hydrocarbons (PAH)/chlorophenol [17]. Additionally, Guo and coworkers [23] studied the sorption of tylosin (TYL) and sulfamethazine (SMT), two ionizable antibiotics commonly used in agriculture as veterinary therapeutics and growth promoters, to solid matter HA.…”

Section: Introductionmentioning

confidence: 99%

Influence of Organic Matter on the Sorption of Cefdinir, Memantine and Praziquantel on Different Soil and Sediment Samples

et al. 2022

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Pharmaceuticals are known for their great effects and applications in the treatment and suppression of various diseases in human and veterinary medicine. The development and modernization of science and technologies have led to a constant increase in the production and consumption of various classes of pharmaceuticals, so they pose a threat to the environment, which can be subjected to the sorption process on the solid phase. The efficiency of sorption is determined by various parameters, of which the physicochemical properties of the compound and the sorbent are very important. One of these parameters that determine pharmaceutical mobility in soil or sediment is the soil–water partition coefficient normalized to organic carbon (Koc), whose determination was the purpose of this study. The influence of organic matter, suspended in an aqueous solution of pharmaceutical (more precisely: cefdinir, memantine, and praziquantel), was studied for five different types of soil and sediment samples from Croatia. The linear, Freundlich, and Dubinin–Raduskevich sorption isotherms were used to determine specific constants such as the partition coefficient Kd, which directly describes the strength of sorbate and sorbent binding. The linear model proved to be the best with the highest correlation coefficients, R2 > 0.99. For all three pharmaceuticals, a positive correlation between sorption affinity described by Kd and Koc and the amount of organic matter was demonstrated.

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Interaction between Diclofenac and Soil Humic Acids

Cited by 8 publications

References 28 publications

Speciation Analysis of Aqueous Nanoparticulate Diclofenac Complexes by Solid-Phase Microextraction

Speciation Analysis of Aqueous Nanoparticulate Diclofenac Complexes by Solid-Phase Microextraction

Immobilization of Pharmaceuticals in Soils

Influence of Organic Matter on the Sorption of Cefdinir, Memantine and Praziquantel on Different Soil and Sediment Samples

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