Interaction between clopidogrel and proton pump inhibitors

Friesen, Mark

doi:10.1503/cmaj.1090014

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…In contrast to omeprazole and lansoprazole, rabeprazole is not a potent in vitro inhibitor of cytochrome P450 2C19 27 and is predominantly metabolised by a non‐enzymatic pathway 28 . Although the metabolite rabeprazole thioether is a potent in vitro inhibitor of cytochrome P450 2C19, its concentration in vivo is about 30% that of its parent compound 27,29 . Given these differences, it is difficult to conclude without further evidence, that rabeprazole would interact with clopidogrel in a comparable way to omeprazole and lansoprazole.…”

Section: Proton Pump Inhibitors and Clopidogrel: The Evidence Thus Farmentioning

confidence: 99%

“…28 Although the metabolite rabeprazole thioether is a potent in vitro inhibitor of cytochrome P450 2C19, its concentration in vivo is about 30% that of its parent compound. 27,29 Given these differences, it is difficult to conclude without further evidence, that rabeprazole would interact with clopidogrel in a comparable way to omeprazole and lansoprazole. In comparison, seven recently published abstracts and studies demonstrated no associations in patients co-prescribed PPI and clopidogrel with reductions in platelet inhibition or adverse clinical outcomes ( Table 2).…”

Section: Proton Pump Inhibitors and Clopidogrel: The Evidence Thus Farmentioning

confidence: 99%

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Proton pump inhibitor and clopidogrel interaction: The case for watchful waiting

Tan

Yan

Hunt

et al. 2010

J of Gastro and Hepatol

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Clopidogrel is an integral part of the management of several important vascular diseases. However the medium to long term clinical outcomes are poorer for these patients if they experience gastro-intestinal bleeding, hence patients with risk factors for gastro-intestinal bleeding are frequently prescribed proton pump inhibitors. Conflicting evidence exists as to the existence of an adverse interaction between clopidogrel and proton pump. This review examines the original studies, which suggested the adverse interaction, the subsequent and most recent studies, the pharmaco-dynamics of the two drugs and suggests an algorithm for the use of clopidogrel with proton pump inhibitors.

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Section: Proton Pump Inhibitors and Clopidogrel: The Evidence Thus Farmentioning

confidence: 99%

Section: Proton Pump Inhibitors and Clopidogrel: The Evidence Thus Farmentioning

confidence: 99%

Proton pump inhibitor and clopidogrel interaction: The case for watchful waiting

Tan

Yan

Hunt

et al. 2010

J of Gastro and Hepatol

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Current awareness: Pharmacoepidemiology and drug safety

2009

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 23 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Antidiabetic Agents; 21 Contrast Agents; 22 Bone Conservation Agents; 23 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Interaction between clopidogrel and proton pump inhibitors

Cited by 2 publications

References 11 publications

Proton pump inhibitor and clopidogrel interaction: The case for watchful waiting

Proton pump inhibitor and clopidogrel interaction: The case for watchful waiting

Current awareness: Pharmacoepidemiology and drug safety

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