Interaction between cationic agents and small interfering RNA and DNA molecules

PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding

“…This correlates well with the data obtained by fluorescence spectroscopy. As a result, the minimal effect of the G1-HCl on the CD spectra of the DNA indicates their external binding to the DNA phosphate groups [ 18 , 53 , 54 ]. Change in the nature of the effect (hyperchromia) with a growth in the bathochromic shift with an increase of the G1-HCl concentration made it possible to conclude that the structure of the complexes changed due to further binding along the DNA groove [ 55 ].…”

“…It can result from displacing the DAPI molecules by the macrocycles from the DNA groove. This mechanism explains quenching of the DAPI fluorescence in most works [53][54][55]. Thus, we assume that the G1-HCl form at least two types of complexes with DNA, i.e., by binding to the biopolymer at phosphate groups and in the groove.…”

Some Features of Surfactant Organization in DNA Solutions at Various NaCl Concentrations

“…The UV irradiation of the surfactant solution induces a trans–cis conformational transition of the azobenzene group, which is easily monitored by a change in the absorption spectra. , Same UV-induced isomerization of surfactants after formation of their complexes with DNA causes an increase in DNA volume because of lower possibility of cis-isomer to produce DNA packaging at the same concentration as for trans-isomer. , This property of the surfactant can be used in light-induced reversible compaction–decompaction of DNA to create bionanostructures for various purposes. ,− …”

Molecular engineering of complexation between RNA and biodegradable cationic gemini surfactants: role of the hydrophobic chain length

“…4 In contrast to deoxyribonucleic acid (DNA), with its specific 3D pockets for effective binding of small molecules RNA provides many advantages as a desirable option for therapeutic intervention in drug discovery. 5,6 There are several types of compounds that can modify the functions of RNA, such as surfactants, 1,2 metal-based compounds, 7–9 antibiotics, 10 synthetic peptide motifs, 11 etc. , which target RNA with valuable affinity and specificity.…”

“…There has been considerable attention in recent years on studies concerning the interaction of nucleic acids with different types of surfactants. [1][2][3] Ribonucleic acid (RNA) is an adaptable molecule that has a significant role in various biological processes, including living cells, and it has been found to be the major regulator in diverse gene expression. 4 In contrast to deoxyribonucleic acid (DNA), with its specific 3D pockets for effective binding of small molecules RNA provides many advantages as a desirable option for therapeutic intervention in drug discovery.…”