Interaction between blood flow and motility in normal and inflamed ileum

Abstract

The alterations in local and superior mesenteric blood flow during ileal inflammation and their correlations with motility in the normal and the inflamed ileum were investigated in the conscious state. Ileal inflammation decreased the local mesenteric blood flow but had no significant effect on the superior mesenteric blood flow. A significant reduction or an increase in local mesenteric blood flow in the normal or the inflamed ileum had no effect on local contractile activity. The vascular reactivity to vaso-dilators and vaso-constrictors was significantly reduced during inflammation. Local mesenteric blood flow increased significantly in the descending segment ahead of a caudal propagating giant migrating contraction. The local mesenteric blood flow oscillated during a migrating motor complex (MMC) cycle. We conclude that a several-fold increase or decrease in local mesenteric blood flow lasting for several minutes does not affect contractility. Ileal inflammation decreases local mesenteric blood flow but does not affect the total blood flow to the small intestine.

Angiotensin II‐induced contractions in human jejunal wall musculature in vitro

“…provided less conclusive results. In the latter study, increased motility in response to Ang II administration was detected in only three of five normal dogs and identical results were obtained in dogs with an artificially induced Crohn’s‐like inflammation (Cowles et al. 1999).…”

The role of the sympathetic nervous system in intestinal inflammation

“…98 In addition, the increase in blood flow induced by the b adrenergic agonist isoproterenol was markedly lower in inflamed ileum. 99 These studies in animal models of intestinal inflammation support the concept of a b to a adrenergic shift. The functional consequences are further corroborated by repulsion of sympathetic nerve fibres ( fig 5B).…”

Effect of MK‐467 on organ blood flow parameters detected by contrast‐enhanced ultrasound in dogs treated with dexmedetomidine

“…Cowles et al. () have shown that transient reduction of blood flow does not interfere with motility of the ileum in dogs. The effects of transient reduced blood flow in the duodenum of dogs remain to be elucidated.…”

“…Our study revealed that the addition of MK-467 also attenuates the DEX-induced reduction of blood flow in the small intestine. Cowles et al (1999) have shown that transient reduction of blood flow does not interfere with motility of the ileum in dogs. The effects of transient reduced blood flow in the duodenum of dogs remain to be elucidated.…”