Interaction between angiotensin IV and adenosine A1 receptor related drugs in passive avoidance conditioning in rats

Tchekalarova, Jana; Kambourova, T; Georgiev, Vasil

doi:10.1016/s0166-4328(01)00198-x

Cited by 16 publications

(10 citation statements)

References 18 publications

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“…Ang IV, in contrast to Ang II, had no effect on memory consolidation or retrieval in the passive avoidance task when a similar dose was injected into the dorsal hippocampus [173,174]. Ang IV improved memory consolidation in the passive avoidance task when injected into the lateral ventricle after the training session [3,168,182] and enhanced memory retrieval when injected before the testing session [171] (Table 4). These effects were observed when Ang IV was administered at a typical dose of 1 nmol, but the involved receptor subtype is not clearly established.…”

Section: Effects Of Ang II and Ang Iv On Learning And Memorymentioning

confidence: 99%

“…These effects were observed when Ang IV was administered at a typical dose of 1 nmol, but the involved receptor subtype is not clearly established. In one study, [Sar 1 ,Ile 8 ]‐Ang II impaired memory consolidation in the inhibitory avoidance task and blocked the memory‐enhancing effect of Ang IV [182], suggesting that the effect on memory consolidation may be mediated through AT 1 or AT 2 receptors. However, Wright et al, demonstrated that administration of divalinal‐Ang IV after training impaired memory consolidation in the passive avoidance task, thus suggesting a role for the AT 4 receptor [183].…”

Section: Effects Of Ang II and Ang Iv On Learning And Memorymentioning

confidence: 99%

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Ang II and Ang IV: Unraveling the Mechanism of Action on Synaptic Plasticity, Memory, and Epilepsy

Bundel¹,

Smolders²,

Vanderheyden³

et al. 2008

CNS Neuroscience & Therapeutics

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The central angiotensin system plays a crucial role in cardiovascular regulation. More recently, angiotensin peptides have been implicated in stress, anxiety, depression, cognition, and epilepsy. Angiotensin II (Ang II) exerts its actions through AT(1) and AT(2) receptors, while most actions of its metabolite Ang IV were believed to be independent of AT(1) or AT(2) receptor activation. A specific binding site with high affinity for Ang IV was discovered and denominated "AT(4) receptor". The beneficiary effects of AT(4) ligands in animal models for cognitive impairment and epileptic seizures initiated the search for their mechanism of action. This proved to be a challenging task, and after 20 years of research, the nature of the "AT(4) receptor" remains controversial. Insulin-regulated aminopeptidase (IRAP) was first identified as the high-affinity binding site for AT(4) ligands. Recently, the hepatocyte growth factor receptor c-MET was also proposed as a receptor for AT(4) ligands. The present review focuses on the effects of Ang II and Ang IV on synaptic transmission and plasticity, learning, memory, and epileptic seizure activity. Possible interactions of Ang IV with the classical AT(1) and AT(2) receptor subtypes are evaluated, and other potential mechanisms by which AT(4) ligands may exert their effects are discussed. Identification of these mechanisms may provide a valuable target in the development in novel drugs for the treatment of cognitive disorders and epilepsy.

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Section: Effects Of Ang II and Ang Iv On Learning And Memorymentioning

confidence: 99%

Section: Effects Of Ang II and Ang Iv On Learning And Memorymentioning

confidence: 99%

Ang II and Ang IV: Unraveling the Mechanism of Action on Synaptic Plasticity, Memory, and Epilepsy

Bundel¹,

Smolders²,

Vanderheyden³

et al. 2008

CNS Neuroscience & Therapeutics

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“…In addition, angiotensin IV exerts an improvement of retention in passive avoidance tasks, whereas angiotensin II analogs impair this effect. Interestingly, the selective adenosine A(1) receptor agonist cyclopentyladenosine (CPA) attenuates angiotensin-IV-induced memory enhancement (Tchekalarova et al 2001b) indicating an interaction of angiotensin IV with adenosine. This interaction seems to be context-specific since, in this experimental design, adenosine A1 receptor agonists attenuate angiotensin-IV-induced effects, whereas adenosin A1 receptor agonists potentiate the effects of angiotensin IV on seizure threshold and kindling (Tchekalarova et al 2001a).…”

Section: Effects Of Angiotensin IV On Behaviormentioning

confidence: 99%

Angiotensin IV in the central nervous system

Halbach

2003

Cell and Tissue Research

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The mammalian brain harbors a renin-angiotensin system (RAS), which is independent from the peripheral RAS. Angiotensin II is a well-studied member of the RAS and exerts most of the known angiotensin-mediated effects on fluid and electrolyte homeostasis, autonomic activity, neuroendocrine regulation, and behavior. This review summarizes a mass of compelling new evidence for the biological role of an active (3-8) fragment of angiotensin II, named angiotensin IV. Angiotensin IV binds to a widely distributed binding site in the brain, but which is different from the known angiotensin II receptors AT1 and AT2. Angiotensin IV has been implicated in a number of physiological actions, including the regulation of blood flow, the modulation of exploratory behavior, and processes attributed to learning and memory. Furthermore, angiotensin IV may also be involved in neuronal development. Collectively, the available evidence suggests that angiotensin IV is a potent neuropeptide, involved in a broad range of brain functions.

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“…Recent studies have contributed to clarify their role in the fine-tuning mode through which these peptides modulate the brain excitability (seizure susceptibility, hypoxia, some types of memory, anxiety states, etc.) (Georgiev et al, 1984;Georgiev and Opitz, 1999;Tchekalarova and Georgiev, 1999;Tchekalarova et al, 2001b;Gard, 2002;McKinley et al, 2003;Wright and Harding, 2004). The underlying mechanisms of this regulation are not very clear yet.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin peptides modulatory system: how is it implicated in the control of seizure susceptibility?

Tchekalarova

Georgiev

2005

Life Sciences

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Interaction between angiotensin IV and adenosine A1 receptor related drugs in passive avoidance conditioning in rats

Cited by 16 publications

References 18 publications

Ang II and Ang IV: Unraveling the Mechanism of Action on Synaptic Plasticity, Memory, and Epilepsy

Ang II and Ang IV: Unraveling the Mechanism of Action on Synaptic Plasticity, Memory, and Epilepsy

Angiotensin IV in the central nervous system

Angiotensin peptides modulatory system: how is it implicated in the control of seizure susceptibility?

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