Interaction between anemia and blood levels of iron, zinc, copper, cadmium and lead in children

Turgut, Sebahat; Polat, Azız; Inan, Murat; Turgut, Günfer; Emmungil, Gülten; Bican, Mevlüt; Karakuş, Tuğrul; Genç, Osman

doi:10.1007/s12098-007-0147-2

Cited by 81 publications

(68 citation statements)

References 19 publications

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“…In our case, the mobile As pool in soils is represented by inorganic arsenate (Marin et al 1993) suggesting possible intensification of AsCu interaction. The other previously described interactions such as As-Fe (Paul et al 2002), Cd-Fe (Turgut et al 2007), or Cd-Cu (Chmielnicka and Sowa 1996) were not confirmed in our experiment. As already mentioned, the individual experiments differed in element dose and application, element source, and duration of the experiment.…”

Section: Discussioncontrasting

confidence: 86%

“…For example, calcium and/or zinc deficiency can result in increasing resorption of lead and cadmium (Bencko et al 1995). Increased Cd, Cu, and Pb levels were observed in the blood of anaemic children (Turgut et al 2007). Similarly, daily rat exposition to 15 mg/kg CdCl 2 for 30 days resulted in anaemia followed by the changes in the metabolism and antioxidative activity of erythrocytes (Kostic et al 1993).…”

Section: Introductionmentioning

confidence: 95%

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Long-term effect of diet amended by risk elements contaminated soils on risk element penetration and physiological parameters of rats

Vlčková¹,

Malinová²,

Koubková³

et al. 2014

CZECH J ANIM SCI

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ABSTRACT:The long-term accumulation of risk elements (As, Cd, Pb) originated from differently contaminated soils in rat organism was investigated during a model two-generation experiment. The effect of soil contamination level, gender, and length of exposure as well as the interactions between risk elements and selected essential macro-and microelements were studied. Rat diet contained 10% of individual soils (based on dry weight): (i) Fluvisol heavily polluted by As, Cd, Zn, and Pb, (ii) Luvisol contaminated by As, Cd, and Zn, and (iii) uncontaminated Chernozem. Male and female Wistar rats used for the experiment were housed in cages in a room with controlled temperature for 60 days and were fed ad libitum the mentioned diets. Subsequently, the pregnant females were continuously fed the experimental diet until weaning when the young animals were separated to male and female and fed the experimental diet till day 110 of age. The element contents in rat tissues reflected the risk element contents in contaminated soils. The bioaccessibility and bioavailability of the risk elements decreased in the order Cd>As>Pb and was affected by the soil physicochemical parameters. No significant differences were observed between male and female rats as well as between the first and the second generation. However, interactions were reported among the risk elements where the high cadmium content in Fluvisol resulted in increasing arsenic accumulation in the rat liver. Moreover, arsenic-copper interactions were observed where significant increase of the copper level was determined in kidney of the animals fed Luvisol exceeding 50-fold the maximum permissible limits for As content in agricultural soils. Among the hematological and biochemical characteristics of rats, total erythrocyte count (Er), hematocrit (Hct) increased confirming adverse effect of soil-derived risk elements especially in male rats.

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Section: Discussioncontrasting

confidence: 86%

Section: Introductionmentioning

confidence: 95%

Long-term effect of diet amended by risk elements contaminated soils on risk element penetration and physiological parameters of rats

Vlčková¹,

Malinová²,

Koubková³

et al. 2014

CZECH J ANIM SCI

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“…Similar effect was observed by Hiratsuka et al (1996) in rats intravenously exposed to Cd. Also Turgut et al (2007) described that high cadmium and lead decreased iron absorption and negatively affected hematological parameters. Except for lower Fe levels in the treated rat tissues, no significant changes in hematological parameters were registered in our experiment.…”

Section: Discussionmentioning

confidence: 99%

Effect of the diet amended with risk elements contaminated soil on risk elements content in tissues and hematological parameters of rats

Száková¹,

Novosadová²,

Zidek³

et al. 2012

CZECH J ANIM SCI

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Penetration of rat organisms by risk elements (As, Cd, Pb) originated from differently contaminated soils as well as interactions between the risk elements and selected essential macro-and microelements were investigated. Rat diet contained 10% of individual soils (based on dry weight) which were: (i) Fluvisol heavily polluted by As, Cd, Zn, and Pb, (ii) Luvisol contaminated by As, Cd, and Zn, and (iii) uncontaminated Chernozem. Male Wistar rats used for the experiment were housed in cages in a room with controlled temperature for 60 days and fed ad libitum on the mentioned diet. The levels of both risk and essential elements were measured in liver, kidney, and bones of the animals and main biochemical parameters were determined to assess potential toxic effect of the soil-derived risk elements. Alternatively, in vitro Physiologically Based Bioavailability Test (PBET) was used for evaluation of the bioaccessible pool of elements in the soil-amended diets. The element contents in the rat tissues reflected the risk element contents in the contaminated soils. Bioaccessibility and bioavailability of the risk elements decreased in the order Cd > As > Pb and were influenced by the soil physicochemical parameters. Significant changes in essential elements (Cu, Fe, Mg, P) deposition in rat tissues attended the high levels of the risk elements. Total leukocyte count in the blood of the rats fed the heavy polluted soil indicated adverse effect of soil-derived risk elements on biochemical parameters of the animals.

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“…People can be exposed to toxic pollutants like lead, cadmium, mercury and arsenic through intake of polluted food and water or contact with contaminated dust, soil, or air (2).Cigarette smoking and alcohol intake can also increase lead levels in blood and seminal plasma (3,4,5). Deficiencies of dietary calcium, zinc and iron may increase lead level in blood as well (6,7,8).…”

Section: Introductionmentioning

confidence: 99%

Environmental Lead Exposure and Male Infertility

Al-Omary¹,

Alawa²,

jaafar³

2016

IOSR

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Interaction between anemia and blood levels of iron, zinc, copper, cadmium and lead in children

Abstract: High copper, cadmium and lead decreased iron absorption and negatively affected hematological parameters.

Cited by 81 publications

References 19 publications

Long-term effect of diet amended by risk elements contaminated soils on risk element penetration and physiological parameters of rats

Long-term effect of diet amended by risk elements contaminated soils on risk element penetration and physiological parameters of rats

Effect of the diet amended with risk elements contaminated soil on risk elements content in tissues and hematological parameters of rats

Environmental Lead Exposure and Male Infertility

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