Interaction between alcohol deprivation and morphine withdrawal in mice

Salimov, R. M.; Salimova, Natalia; Klodt, P. D.; Maisky, A. I.

doi:10.1016/0376-8716(93)90046-s

Cited by 32 publications

(13 citation statements)

References 22 publications

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“…The ADE is a robust phenomenon that has been observed in rats (McKinzie et al, 1998;Rodd-Henricks et al, 2000b;Sinclair and Senter, 1967), mice (Salimov et al, 1993), monkeys (Kornet et al, 1990;Sinclair, 1971), and humans (Burish et al, 1981;Mello and Mendelson, 1972). An ADE can be observed after a short (12 hr or less; Sinclair and Li, 1989) or long (up to 75 days; Sinclair et al, 1973) deprivation interval.…”

mentioning

confidence: 94%

The Expression of an Alcohol Deprivation Effect in the High–Alcohol‐Drinking Replicate Rat Lines Is Dependent On Repeated Deprivations

Rodd-Henricks

McKinzie

Murphy

et al. 2000

Alcoholism Clin & Exp Res

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confidence: 94%

The Expression of an Alcohol Deprivation Effect in the High–Alcohol‐Drinking Replicate Rat Lines Is Dependent On Repeated Deprivations

Rodd-Henricks

McKinzie

Murphy

et al. 2000

Alcoholism Clin & Exp Res

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“…mice (Salimov et al, 1993), monkeys ( Kornet et al, 1990;Sinclair, 1971), and humans (Burish et al, 1981;Mello and Mendelson, 1972). An ADE can be observed after short (12-hr or less; Sinclair and Li, 1989) or long (up to 75 days; Sinclair et al, 1973) deprivation intervals.…”

mentioning

confidence: 95%

Alcohol Deprivation Effect Is Prolonged in the Alcohol Preferring (P) Rat After Repeated Deprivations

Rodd-Henricks

McKinzie

Shaikh

et al. 2000

Alcoholism Clin & Exp Res

119

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“…Renewed access to ethanol solutions after a period of deprivation for several days/weeks leads to a pronounced, although temporary, increase in voluntary ethanol intake. The EDE is observed in a variety of species including rats (McKinzie et al, 1998;Rodd-Henricks et al, 2000a;Sinclair and Senter, 1967), mice (Salimov et al, 1993), monkeys (Kornet et al, 1990;Sinclair, 1971), and humans (Burish et al, 1981;Mello and Mendelson, 1972). Short (12-h or less; Sinclair and Li, 1989) or long (up to 75 days; Sinclair et al, 1973) deprivation intervals both produce an EDE in rats.…”

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confidence: 99%

Characterization of the ethanol-deprivation effect in substrains of C57BL/6 mice

Khisti

Wolstenholme

Shelton

et al. 2006

Alcohol

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Ethanol craving plays a major role in relapse drinking behavior. Relapse and ethanol craving are an important focus for the treatment of alcoholism. The ethanol deprivation effect (EDE) is a widely used animal model of alcohol craving. While the EDE is widely studied in rats, the molecular mechanisms underlying EDE are not clearly understood. The C57BL/6 inbred mouse strain is widely used for behavioral and molecular analyses of ethanol drinking but studies on the EDE have not been reported in this strain. In the present study, we characterized a simple behavioral protocol that rapidly and reliably induced EDE in C57BL/6 mice. Briefly, singlehoused adult male C57BL/6NCrl and C57BL/6J mice were presented at the beginning of dark phase with two-bottle choice drinking containing either 10 % w/v ethanol or tap water for 18-hrs/ day, as well as food ad libitum. Following ethanol drinking for 4 days or 14-days, mice were deprived of ethanol for a period of 4 days. To study EDE, mice were reinstated with two-bottles containing either ethanol (10 % w/v) or water. Mice were exposed to single or multiple ethanol deprivation cycles. Ethanol consumption (g/kg/18-hrs) and percent ethanol preference (% preference/18-hrs) was recorded for individual mice. C57BL/6NCrl mice consumed moderate amounts (4.78 ± 0.63 g/kg) of ethanol but showed robust EDE after ethanol drinking episodes (4 days or 14 days) as evidenced by increased ethanol consumption and ethanol preference following re-instatement of ethanol. While repeated ethanol deprivation in C57BL/6NCrl mice transiently increased ethanol consumption and ethanol preference, the magnitude of these behaviors was reduced as compared to the first deprivation cycle. In contrast, the C57BL/6J substrain consumed substantially higher levels (9.65 ± 0.90 g/kg) of ethanol but did not show a clear EDE after single or multiple ethanol deprivation cycles. In conclusion, we established a simple and reliable behavioral model to study EDE in C57BL/6NCrl mice. A reliable behavioral model to study EDE in inbred C57BL/6NCrl mice could greatly facilitate further studies on molecular mechanisms of ethanol craving behavior.

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Interaction between alcohol deprivation and morphine withdrawal in mice

Cited by 32 publications

References 22 publications

The Expression of an Alcohol Deprivation Effect in the High–Alcohol‐Drinking Replicate Rat Lines Is Dependent On Repeated Deprivations

The Expression of an Alcohol Deprivation Effect in the High–Alcohol‐Drinking Replicate Rat Lines Is Dependent On Repeated Deprivations

Alcohol Deprivation Effect Is Prolonged in the Alcohol Preferring (P) Rat After Repeated Deprivations

Characterization of the ethanol-deprivation effect in substrains of C57BL/6 mice

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