Interaction among Caveolin-1 genotypes (rs3807987/rs7804372), H. pylori infection, and risk of gastric cancer in a Chinese population

Abstract

Caveolin-1, a candidate tumor suppressor, interacts with a number of transducing molecules and plays a regulatory role in several signaling pathways. Recently, a study revealed that Cav-1 G14713A (rs3807987)/T29107A (rs7804372) polymorphisms might be associated with the susceptibility to certain cancers. In this study, we evaluated the interaction among Caveolin-1 genotypes (rs3807987/rs7804372) and Helicobacter pylori infection and increased risk of gastric cancer among the Chinese population. Blood specimens were collected from 412 gastric cancer cases to 412 noncancer controls between January 2004 and December 2012 in Liaoning Province, China. Caveolin-1 genotypes (rs3807987/rs7804372) were determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Enzyme-linked immunosorbent assays were used to measure serum levels of anti-H. pylori IgG. Odds ratio and 95 % confidence interval were calculated using multivariate logistic regression adjusted by sex and age. There were significant differences between gastric cancer and control groups in the distribution of their genotypes and allelic frequencies of the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms, respectively. An elevated risk of gastric cancer was observed in patients with H. pylori infection combined with the Cav-1 G14713A, but not T29107A genotypes. The A allele of G14713A shows an interaction with H. pylori infection that increases the risk of gastric cancer.

Functional polymorphisms of caveolin-1 variants as potential biomarkers of esophageal squamous cell carcinoma

“…There was no association between any of the other tested SNPs and ESCC risk. These results were consistent with other studies of CAV1 genetic polymorphism-related susceptibility to breast, colorectal and gastric cancers (Liu et al, 2011;Yang et al, 2010;Zhang et al, 2014). There was also an ethnic difference in the frequencies of genetic polymorphisms.…”

“…To date, many studies have explored the association of functional polymorphisms of CAV1 with the susceptibility to oral (Bau et al, 2011), breast (Liu et al, 2011), colorectal (Yang et al, 2010), gastric (Zhang et al, 2014) and hepatocellular (Hsu et al, 2013) cancers. For ESCC, several previous studies have reported clinical impact of CAV1 expression in esophageal carcinoma by immunohistochemical or cDNA expression array analysis, indicating a statistically significant increased expression of CAV1 mRNA and protein levels (Hu et al, 2001;Kato et al, 2002).…”

Quantitative assessment of caveolin-1 G14713A polymorphism and cancer susceptibility in the Asian population

“…For example, some studies indicated that CAV1 G14713A polymorphism was associated with cancer risk, such as esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, and breast cancer. 9 , 10 , 12 , 16 Other studies demonstrated that CAV1 G14713A polymorphism was not associated with the risk of cancer, including prostate cancer and nasopharyngeal carcinoma. 14 , 15 To provide a more detailed overview of the association, five genetic models were used in the current meta-analysis.…”

Caveolin-1 Polymorphisms and Cancer risk in Asian: A Meta - Analysis

“…Figure 1 presents the detailed process of selecting and excluding studies. In the 13 articles, all studies were case-control studies with the following SNP distribution: 11 articles were about polymorphism rs1997623 [19][20][21][22][23][24][25][26][27][28][29], 11 articles were about rs12672038 [19][20][21][22][23][24][25][26][27][28][29], 10 articles were about rs3757733 [19,[21][22][23][24][25][26][27][28][29], 12 articles were about rs3807987 [18][19][20][21][22][23][24][25][26][27][28][29], 9 articles were about rs3807992 [18,19,[21][22]…”

“…More than 20 SNPs in the CAV-1 promoter were detected in different types of cancers, some of which were thought to be genetic risk factors [17,18]. Six SNPs (rs1997623, rs3807987, rs12672038, rs3757733, rs7804372, and rs3807992) were most frequently studied among Asians.…”