Interacción calmodulina-melatonina: efectos sobre la oxidación de la calmodulina y la actividad de la calmodulina cinasa II

Abstract

Reactive oxygen species are the most reactive molecules that, among other characteristics, have different half-lives, cellular concentrations, and reaction targets. They are present in different compartments and react with different gradients of molecules in the cell. In particular, proteins can react with almost all oxygen radicals present in the cell, and ultimately, these oxidation reactions produce conformational changes in these molecules due to carbonylation and sulfoxidation that impact different cellular functions. In the case of calmodulin, a protein that acts as a Ca 2+ sensor, it can be oxidized by oxygen free radicals and can undergo modifications in its secondary structure, and consequently, its function can be altered until it is degraded. viii 12. Referencias .