Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC): Childhood cancer and the consumption of Debendox and related drugs in pregnancy

McKinney, Patricia A.; Cartwright, R.A.; Stiller, Charles; Hopton, P A; Mann, J R; Birch, Jillian M; Hartley, A.; Waterhouse, J. A. H.; Johnston, Hannah E.

doi:10.1038/bjc.1985.278

Cited by 16 publications

(9 citation statements)

References 22 publications

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“…Apart from viral infection and anaemia, there was little support within our data for associations between leukaemia and maternal use of anticonvulsants or antibiotics during pregnancy or with drugs given to the mother in labour, the odds ratios for anaesthetics, entonox and pethidine all being close to unity (Doll, 1973;KinnierWilson et al, 1981;McKinney et al, 1985;Robison et al, 1988;Gilman et al, 1989;Golding et al, 1990;Cnattingius et al, 1995).…”

Section: In Utero Exposuresmentioning

confidence: 74%

Leukaemia and non-Hodgkin's lymphoma in children and young adults: are prenatal and neonatal factors important determinants of disease?

Roman

Ansell²,

Bull³

1997

Br J Cancer

126

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Summary A medical record-based study of leukaemia and non-Hodgkin's lymphoma diagnosed before the age of 30 years was carried out at three hospitals in the south of England. Findings for 177 cases and 354 age-and sex-matched controls are presented here. For documented viral infection in pregnancy, the odds ratio (OR) was 6.0 [95% confidence interval (Cl) 1.2-29.7] for leukaemia and infinity (95% Cl 1.2-) for non-Hodgkin's lymphoma. Mothers of leukaemic cases were more likely to be anaemic, the OR for a pregnancy haemoglobin below 10 g being 3.8 (95% Cl 1.3-11.1). An association with birthweight was found for acute myeloid leukaemia, the OR for birthweights > 3500 g being 6.2 (95% Cl 1.3-29.8). Further, the preceding siblings of those diagnosed with any form of leukaemia were also more likely to weigh > 3500 g at birth (OR 2.2; 95% Cl 1.1-4.4). Overall, leukaemic cases appeared to be comparatively robust at birth with respect to other indicators of well-being, the ORs for jaundice, phototherapy, admission to special care nursery and neonatal intensive care all being less than 1.0. Further, no relation between childhood leukaemia and neonatal administration of intramuscular vitamin K was noted (OR 0.6, 95% Cl 0.3-1.4; for acute lymphoblastic leukaemia diagnosed between the ages of 1 and 6 years).

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Section: In Utero Exposuresmentioning

confidence: 74%

Leukaemia and non-Hodgkin's lymphoma in children and young adults: are prenatal and neonatal factors important determinants of disease?

Roman

Ansell²,

Bull³

1997

Br J Cancer

126

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“…The IRESCC was established to investigate the role of possible aetiological factors in childhood cancer with particular emphasis on environmental exposures to the foetus and family history of diseases (Cartwright et al, 1984;Hopton et al, 1985;Johnston et al, 1986;McKinney and Stiller, 1986;McKinney et al, 1985;1987;Hartley et al, 1988a;1988b;Birch et al, 1990;Mann et al, 1993). Study design, control selection and data collection procedures have been published in some considerable detail ; a summary is provided here.…”

Section: Methodsmentioning

confidence: 99%

Childhood cancer and parental use of tobacco: findings from the inter-regional epidemiological study of childhood cancer (IRESCC)

et al. 2001

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Summary Parental smoking data have been re-abstracted from the interview records of the Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC) to test further the hypothesis that paternal cigarette smoking is a risk factor for the generality of childhood cancer. Reported cigarette smoking habits for the parents of 555 children diagnosed with cancer in the period 1980-1983 were compared, in two separate matched pairs analyses, with similar information for the parents of 555 children selected from GP lists (GP controls) and for the parents of 555 hospitalized children (hospital controls). When cases were compared with GP controls there was a statistically significant positive trend (P = 0.02) between the risk of childhood cancer and paternal daily consumption of cigarettes before the pregnancy; there was no significant trend for maternal smoking habit. When cases were compared with hospital controls there was a statistically significant negative trend (P < 0.001) between the risk of childhood cancer and maternal daily consumption of cigarettes before the pregnancy; there was no significant trend for paternal smoking habit. Neither of the significant trends could be explained by adjustment for socioeconomic grouping, ethnic origin or parental age at the birth of the child, or by simultaneous analysis of parental smoking habits. Relations between maternal consumption of cigarettes and birth weights suggested that (maternal) smoking data were equally reliable for case and control subjects, although comparisons with national data suggested that the hospital control parents were unusually heavy smokers. These findings give some support for the hypothesis that paternal cigarette smoking is a potential risk factor for the generality of childhood cancers.

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“…20 Since then, there have been several studies of maternal use of medication in pregnancy and subsequent risk of cancer in the offspring. [21][22][23][24][25][26][27][28][29][30][31][32][33][34] Although several medications and medication categories have been suggested to be transplacental carcinogens, the results from these studies have not been consistent. Because childhood cancers comprise a histologically heterogenous group of cancers with differing demographics and etiology, the majority of these studies have been limited to individual groups of cancer.…”

Section: Discussionmentioning

confidence: 99%

Prenatal exposure to metronidazole and risk of childhood cancer

Thapa

Whitlock

Worrell

et al. 1998

Cancer

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Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC): Childhood cancer and the consumption of Debendox and related drugs in pregnancy

Cited by 16 publications

References 22 publications

Leukaemia and non-Hodgkin's lymphoma in children and young adults: are prenatal and neonatal factors important determinants of disease?

Leukaemia and non-Hodgkin's lymphoma in children and young adults: are prenatal and neonatal factors important determinants of disease?

Childhood cancer and parental use of tobacco: findings from the inter-regional epidemiological study of childhood cancer (IRESCC)

Prenatal exposure to metronidazole and risk of childhood cancer

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