Inter-reader agreement in HRCT detection of pleural plaques and asbestosis in participants with previous occupational exposure to asbestos

Laurent, François; Paris, Christophe; Ferretti, G.; Beigelman, Catherine; Montaudon, Michel; Latrabe, V.; Jankowski, A.; Badachi, Yasmina; Clin, Bénédicte; Gislard, Antoine; Letourneux, M.; Luc, Amandine; Schorlé, Evelyne; Brochard, Patrick; Ameille, J.; Pairon, Jean‐Claude

doi:10.1136/oemed-2014-102336

Cited by 15 publications

(10 citation statements)

References 23 publications

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“…As a matter of fact, significantly greater quantities of PPs were observable in exposed subjects than in the control groups 25 (66%) vs. 2 (5%). PPs can arise even after relatively low exposure to asbestiform fibers and are the most common non-malignant effects (31)(32)(33)35,(54)(55)(56)(57).…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory effects in workers exposed to naturally occurring asbestos fibers

Ledda

Costa

Matera

et al. 2017

Molecular Medicine Reports

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Natural asbestiform fibers are defined 'naturally occurring asbestos' (NOA) and refer to the mineral as a natural component of soils or rocks. The release of NOA fibers into the air from rocks or soils by routine human activities or natural weathering processes represents a risk for human beings. Fluoro-edenite (FE) is a NOA fiber detected in the benmoreitic lava in the area of Biancavilla, South-west slope of Mt. Etna. The aim of the present study was to investigate FE immunotoxicity pathways in a group of 38 occupationally exposed construction workers, in order to find any biological markers of its effect. Subjects underwent respiratory function tests and HRCT total chest scanning. Serum IL-1β, IL-6, IL-8 and TNF-α were measured. The presence of PPs was significantly greater in subjects exposed than in the control (25 vs. 2). In subjects exposed to FE, IL-1β and TNF-α values were significantly higher than the controls. The previously observed increase of IL-1β and IL-18 showed a probable involvement of the proteic complex defined inflammosome by FE fibers.

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Section: Discussionmentioning

confidence: 99%

Immunomodulatory effects in workers exposed to naturally occurring asbestos fibers

Ledda

Costa

Matera

et al. 2017

Molecular Medicine Reports

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“…Asbestosis, however, cannot be distinguished by HRCT from a possible or definite UIP pattern [ 26 ]. The first round of screening of this cohort has been reported [ 1 ] and conversely to the agreement between trained expert readers for the detection of pleural plaques that was good to excellent, the agreement between trained expert readers for the detection of interstitial abnormalities has been reported to be fair to good [ 27 ]. In an attempt to circumvent the subjects with possible mild or moderate asbestosis, we separated those subjects from those with an interstitial pattern inconsistent with UIP, using the criteria defined by ATS/ERS consensus paper [ 20 ].…”

Section: Discussionmentioning

confidence: 97%

Interstitial Lung Abnormalities Detected by CT in Asbestos-Exposed Subjects Are More Likely Associated to Age

Laurent

Benlala

Dournes

et al. 2021

JCM

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Objective: the aim of this study was to evaluate the association between interstitial lung abnormalities, asbestos exposure and age in a population of retired workers previously occupationally exposed to asbestos. Methods: previously occupationally exposed former workers to asbestos eligible for a survey conducted between 2003 and 2005 in four regions of France, underwent chest CT examinations and pulmonary function testing. Industrial hygienists evaluated asbestos exposure and calculated for each subject a cumulative exposure index (CEI) to asbestos. Smoking status information was also collected in this second round of screening. Expert radiologists performed blinded independent double reading of chest CT-scans and classified interstitial lung abnormalities into: no abnormality, minor interstitial findings, interstitial findings inconsistent with UIP, possible or definite UIP. In addition, emphysema was assessed visually (none, minor: emphysema <25%, moderate: between 25 and 50% and severe: >50% of the lung). Logistic regression models adjusted for age and smoking were used to assess the relationship between interstitial lung abnormalities and occupational asbestos exposure. Results: the study population consisted of 2157 male subjects. Interstitial lung abnormalities were present in 365 (16.7%) and emphysema in 444 (20.4%). Significant positive association was found between definite or possible UIP pattern and age (OR adjusted =1.08 (95% CI: 1.02–1.13)). No association was found between interstitial abnormalities and CEI or the level of asbestos exposure. Conclusion: presence of interstitial abnormalities at HRCT was associated to aging but not to cumulative exposure index in this cohort of former workers previously occupationally exposed to asbestos.

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“…Ongoing studies continue to support the increased sensitivity and specificity of HRCT over chest radiography for changes related to occupational lung disease [26,43,[56][57][58], although the level of radiologist expertise can affect interpretation [59]. HRCT proves central in the imaging of classic and emerging pneumoconioses [6,34,[60][61][62][63][64], as well as differentiating occupational lung disease from other ILDs [65,66].…”

Section: Discussion Of Procedures By Variantmentioning

confidence: 98%

ACR Appropriateness Criteria® Occupational Lung Diseases

Imaging¹,

Cox

Chung

et al. 2020

Journal of the American College of Radiology

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Inter-reader agreement in HRCT detection of pleural plaques and asbestosis in participants with previous occupational exposure to asbestos

Abstract: Interpretation of benign asbestos-related thoracic abnormalities requires standardisation of the reading and trained readers, particularly for participants asking for compensation, and with a view to the longitudinal survey of asbestos-exposed workers.

Cited by 15 publications

References 23 publications

Immunomodulatory effects in workers exposed to naturally occurring asbestos fibers

Immunomodulatory effects in workers exposed to naturally occurring asbestos fibers

Interstitial Lung Abnormalities Detected by CT in Asbestos-Exposed Subjects Are More Likely Associated to Age

ACR Appropriateness Criteria® Occupational Lung Diseases

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