2023
DOI: 10.3390/tropicalmed8050285
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Inter-Population Genetic Diversity and Clustering of Merozoite Surface Protein-1 (pkmsp-1) of Plasmodium knowlesi Isolates from Malaysia and Thailand

Abstract: The genetic diversity of pkmsp-1 of Malaysian Plasmodium knowlesi isolates was studied recently. However, the study only included three relatively older strains from Peninsular Malaysia and focused mainly on the conserved blocks of this gene. In this study, the full-length pkmsp-1 sequence of recent P. knowlesi isolates from Peninsular Malaysia was characterized, along with Malaysian Borneo and Thailand pkmsp-1 sequences that were retrieved from GenBank. Genomic DNA of P. knowlesi was extracted from human bloo… Show more

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Cited by 2 publications
(2 citation statements)
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“…Oligonucleotide primers (Table 1) were designed for the nested PCR amplification of the two allelic families within block IV of Pkmsp-1 (Noordin et al, 2023). The primer pairs for the primary amplification flanked the block IV region.…”
Section: Genotyping Of Pkmsp-1 Block IVmentioning
confidence: 99%
See 1 more Smart Citation
“…Oligonucleotide primers (Table 1) were designed for the nested PCR amplification of the two allelic families within block IV of Pkmsp-1 (Noordin et al, 2023). The primer pairs for the primary amplification flanked the block IV region.…”
Section: Genotyping Of Pkmsp-1 Block IVmentioning
confidence: 99%
“…Recently, a genetic diversity analysis on the polymorphic blocks revealed block IV as the most polymorphic with the highest insertion-deletion (indel) rates. Furthermore, two distinct allelic family types (T1 and T2) were identified within this block, thereby highlighting this block as a promising genotyping marker for MOI study of P. knowlesi malaria (Noordin et al, 2023). The present study aimed to investigate the usefulness Pkmsp-1 block IV in assessing MOI of P. knowlesi among clinical isolates from Malaysia.…”
Section: Introductionmentioning
confidence: 96%