Inter-locus antagonistic coevolution as an engine of speciation: Assessment with hemiclonal analysis

Rice, William R.; Linder, Jodell E.; Friberg, Urban; Lew, Timothy A.; Morrow, Edward H.; Stewart, Andrew D.

doi:10.1073/pnas.0501889102

Cited by 138 publications

(175 citation statements)

References 48 publications

Supporting

Mentioning

171

Contrasting

Order By: Relevance

“…Variation in proportion of sperm carrying DNA lesions was manipulated via gamma radiation of males (see below). Males transferring normal or irradiated sperm came from the wild-type laboratory population LHm [38]. In the assay for dominant lethals, females also came from LHm.…”

Section: Materials and Methods (A) Fly Stocksmentioning

confidence: 99%

See 1 more Smart Citation

The effect of sexual harassment on lethal mutation rate in femaleDrosophila melanogaster

et al. 2013

Self Cite

View full text Add to dashboard Cite

The rate by which new mutations are introduced into a population may have far-reaching implications for processes at the population level. Theory assumes that all individuals within a population have the same mutation rate, but this assumption may not be true. Compared with individuals in high condition, those in poor condition may have fewer resources available to invest in DNA repair, resulting in elevated mutation rates. Alternatively, environmentally induced stress can result in increased investment in DNA repair at the expense of reproduction. Here, we directly test whether sexual harassment by males, known to reduce female condition, affects female capacity to alleviate DNA damage in Drosophila melanogaster fruitflies. Female gametes can repair double-strand DNA breaks in sperm, which allows manipulating mutation rate independently from female condition. We show that male harassment strongly not only reduces female fecundity, but also reduces the yield of dominant lethal mutations, supporting the hypothesis that stressed organisms invest relatively more in repair mechanisms. We discuss our results in the light of previous research and suggest that social effects such as density and courtship can play an important and underappreciated role in mediating condition-dependent mutation rate.

show abstract

Section: Materials and Methods (A) Fly Stocksmentioning

confidence: 99%

“…Drosophila melanogaster has been used as a model organism to study male-female coevolution, and the economics of sexual conflict are well-known for this species [38,39]. The cost of sexual conflict in this system is substantial and has been estimated to reduce female fitness by at least 20 per cent [40].…”

Section: Introductionmentioning

confidence: 99%

The effect of sexual harassment on lethal mutation rate in femaleDrosophila melanogaster

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…the laboratories of T. Chapman, B. Charlesworth, A. Chippindale, K. Fowler, L. Mueller, L. Partridge, M. Rose, and P. Service) is to take a large founding population from nature, allow it to adapt to laboratory conditions for hundreds of generations at a persistently large effective size, and then assay evolutionarily interesting phenotypes under these same (or very similar) conditions. We refer to this paradigm as laboratory island analysis and its logical foundation is described in detail in Rice et al (2005).…”

Section: Empirical Evaluation Of Sexual Conflictmentioning

confidence: 99%

“…Only eggs laid in the oviposition vials are used to start the next generation (reduced to 150-200 per vial), so fecundity during this time represents a female's lifetime fecundity. A detailed description of the base population and its propagation can be found in Rice et al (2005).…”

Section: Empirical Evaluation Of Sexual Conflictmentioning

confidence: 99%

Assessing sexual conflict in theDrosophila melanogasterlaboratory model system

Rice

Stewart

Morrow

et al. 2006

Phil. Trans. R. Soc. B

113

140

View full text Add to dashboard Cite

We describe a graphical model of interlocus coevolution used to distinguish between the interlocus sexual conflict that leads to sexually antagonistic coevolution, and the intrinsic conflict over mating rate that is an integral part of traditional models of sexual selection. We next distinguish the 'laboratory island' approach from the study of both inbred lines and laboratory populations that are newly derived from nature, discuss why we consider it to be one of the most fitting forms of laboratory analysis to study interlocus sexual conflict, and then describe four experiments using this approach with Drosophila melanogaster. The first experiment evaluates the efficacy of the laboratory model system to study interlocus sexual conflict by comparing remating rates of females when they are, or are not, provided with a spatial refuge from persistent male courtship. The second experiment tests for a lag-load in males that is due to adaptations that have accumulated in females, which diminish male-induced harm while simultaneously interfering with a male's ability to compete in the context of sexual selection. The third and fourth experiments test for a lag-load in females owing to direct costs from their interactions with males, and for the capacity for indirect benefits to compensate for these direct costs.

show abstract

“…Genomic conflicts can lead to tit-for-tat, or arms-race, evolution between groups of genes within the same genome. William Rice et al (23) explore this issue directly by developing a model evolutionary system with Drosophila melanogaster. In this system, individual haploid chromosome complements (hemiclones) are drawn, using genetic tricks that are possible with Drosophila, from a longstanding laboratory population.…”

Section: The Origins Of Species Barriersmentioning

confidence: 99%