Inter-Individual Variation during Transcranial Direct Current Stimulation and Normalization of Dose Using MRI-Derived Computational Models

Datta, Abhishek; Truong, Dennis Q.; Minhas, Preet; Parra, Lucas C.; Bikson, Marom

doi:10.3389/fpsyt.2012.00091

Cited by 374 publications

(359 citation statements)

References 36 publications

(52 reference statements)

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“…Despite the abundance of research reporting tDCS effects on plasticity, in recent years large inter-individual variability in response to tDCS has been recognized (Datta et al 2012, Puri et al 2015, Wiethoff et al 2014. For example, Fujiyama et al observed that approximately 20% of participants (8 out of 39) did not show the expected corticospinal excitability increase following tDCS with anode placed over M1.…”

Section: Introductionmentioning

confidence: 99%

Preconditioning tDCS facilitates subsequent tDCS effect on skill acquisition in older adults

Fujiyama

Hinder

Barzideh

et al. 2017

Neurobiology of Aging

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Functional motor declines that often occur with advancing age -including reduced efficacy to learn new skills -can have a substantial impact on the quality of life. Recent studies using non-invasive brain stimulation indicate that priming the corticospinal system by lowering the threshold for the induction of long-term potentiation (LTP)-like plasticity before skill training may facilitate subsequent skill learning. Here we utilized 'priming' protocol, in which we used transcranial direct current stimulation (tDCS) applying the cathode over the primary motor cortex (M1) prior to the anode placed over M1 during unimanual isometric force control training (FORCEtraining). Older individuals who received tDCS with the cathode placed over M1 prior to tDCS with the anode placed over M1 concurrent with FORCEtraining showed greater skill improvement and corticospinal excitability increases following the tDCS/FORCEtraining protocol compared to both young and older individuals who did not receive the preceding tDCS with the cathode placed over M1. The results suggested that priming tDCS protocols may be used in clinical settings to improve motor function and thus maintain the functional independence of older adults.

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Section: Introductionmentioning

confidence: 99%

Preconditioning tDCS facilitates subsequent tDCS effect on skill acquisition in older adults

Fujiyama

Hinder

Barzideh

et al. 2017

Neurobiology of Aging

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“…Unfortunately, despite increasing sophistication in these computational models (Wagner et al, 2004;Datta et al, 2009;Sadleir et al, 2010;Parazzini et al, 2011;Datta et al, 2012;Minhas et al, 2012;Datta et al, 2010;Wagner et al, 2007;Datta et al, 2011;Dmochowski et al, 2013;Luu et al, 2016), none of these model predictions have been directly validated to-date. Early validation efforts for simple spherical models used ex vivo recordings (Rush and Driscoll, 1968), surface recordings (Burger and Milaan, 1943) or in vivo recordings in simian (Hayes, 1950).…”

Section: Introductionmentioning

confidence: 99%

Measurements and models of electric fields in the in vivo human brain during transcranial electric stimulation

et al. 2017

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Transcranial electric stimulation aims to stimulate the brain by applying weak electrical currents at the scalp. However, the magnitude and spatial distribution of electric fields in the human brain are unknown. We measured electric potentials intracranially in ten epilepsy patients and estimated electric fields across the entire brain by leveraging calibrated current-flow models. When stimulating at 2 mA, cortical electric fields reach 0.8 V/m, the lower limit of effectiveness in animal studies. When individual whole-head anatomy is considered, the predicted electric field magnitudes correlate with the recorded values in cortical (r = 0.86) and depth (r = 0.88) electrodes. Accurate models require adjustment of tissue conductivity values reported in the literature, but accuracy is not improved when incorporating white matter anisotropy or different skull compartments. This is the first study to validate and calibrate current-flow models with in vivo intracranial recordings in humans, providing a solid foundation to target stimulation and interpret clinical trials.

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“…To date, a number of inter-subject factors have been identified as influencing tDCS including anatomical structure Datta et al, 2012) age (Fujiyama et al, 2014;Moliadze et al, 2014), and potentially even genetic profile (for review see Li et al (2015)). …”

Section: Introductionmentioning

confidence: 99%

Intra-Subject Consistency and Reliability of Response Following 2 mA Transcranial Direct Current Stimulation

et al. 2016

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. (2016) Intrasubject consistency and reliability of response following 2mA transcranial direct current stimulation. Brain Stimulation, 9 (6). pp. 819-825. ISSN 1876-4754 Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/34423/1/Dyke%20et%20al%2018-6-16.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the Creative Commons Attribution Non-commercial No Derivatives licence and may be reused according to the conditions of the licence. For more details see: http://creativecommons.org/licenses/by-nc-nd/2.5/ A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Intra-subject consistency and reliability of response following 2mA transcranial direct current stimulation Abstract BackgroundTranscranial direct current stimulation (tDCS) is a popular non-invasive brain stimulation technique that has been shown to influence cortical excitability. While polarity specific effects have often been reported, this is not always the case, and variability in both the magnitude and direction of the effects have been observed. Objective/ hypothesisWe aimed to explore the consistency and reliability of the effects of tDCS by investigating changes in cortical excitability across multiple testing sessions in the same individuals. A within subjects design was used to investigate the effects of anodal and cathodal tDCS applied to the motor cortex. Four experimental sessions were tested for each polarity in addition to two sham sessions. MethodsTranscranial Magnetic Stimulation (TMS) was used to measure cortical excitability (TMS recruitment curves). Changes in excitability were measured by comparing baseline measures and those taken immediately following 20minutes of 2mA stimulation or sham stimulation. ResultsAnodal tDCS significantly increased cortical excitability at a group level, whereas cathodal tDCS failed to have any significant effects. The sham condition also failed to show any significant changes.Analysis of intra-subject responses to anodal stimulation across four sessions suggest that the amount of change in excitability across sessions was only weakly associated, and was found to have poor reliability acro...

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Inter-Individual Variation during Transcranial Direct Current Stimulation and Normalization of Dose Using MRI-Derived Computational Models

Cited by 374 publications

References 36 publications

Preconditioning tDCS facilitates subsequent tDCS effect on skill acquisition in older adults

Preconditioning tDCS facilitates subsequent tDCS effect on skill acquisition in older adults

Measurements and models of electric fields in the in vivo human brain during transcranial electric stimulation

Intra-Subject Consistency and Reliability of Response Following 2 mA Transcranial Direct Current Stimulation

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