Inter-individual and inter-organ variability in the bioactivation of paracetamol by human liver and kidney tissues

Arzuk, Ege; Turna, Burak; Sözbılen, Murat; Orhan, Hilmi

doi:10.1016/j.etap.2018.05.015

Cited by 10 publications

(2 citation statements)

References 35 publications

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“…The monooxygenase system is localized in ER. Under conditions of ER stress, this system can release superoxide anion and hydrogen peroxide via CYP enzymes . Therefore, ER stress may contribute to TiO 2 NP‐increased ROS in mice.…”

Section: Discussionmentioning

confidence: 99%

“…Under conditions of ER stress, this system can release superoxide anion and hydrogen peroxide via CYP enzymes. 14,26 Therefore, ER stress may contribute to Based on previous studies, we designed an experiment to examine TiO 2 NP-induced ER stress and ROS generation. 9,12 Our results showed that GRP78 and CHOP mRNA and protein expression, mRNA and protein ratios of XBP1-s/t, and protein ratio of ATF6 (90/50 kD) were significantly increased from week 5, indicating that ER stress is induced at this time.…”

Section: Tio 2 Nps Induce Insulin Resistance and Elevation Of Plasmmentioning

confidence: 99%

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Mechanisms of titanium dioxide nanoparticle‐induced oxidative stress and modulation of plasma glucose in mice

Fan

Yao

et al. 2019

Environmental Toxicology

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Titanium dioxide nanoparticles (TiO2 NPs) are reported to increase plasma glucose levels in mice at specific doses. The production and accumulation of reactive oxygen species (ROS) is potentially the most important factor underlying the biological toxicity of TiO2 NPs but the underlying mechanisms are unclear at present. Data from genome‐wide analyses showed that TiO2 NPs induce endoplasmic reticulum (ER) stress and ROS generation, leading to the inference that TiO2 NP‐induced ER stress contributes to enhancement of ROS in mice. Resveratrol (Res) effectively relieved TiO2 NP‐induced ER stress and ROS generation by ameliorating expression of a common set of activated genes for both processes, signifying that ER stress and ROS are closely related. TiO2 NP‐induced ER stress occurred earlier than ROS generation. Upon treatment with 4‐phenylbutyric acid to relieve ER stress, plasma glucose levels tended toward normal and TiO2 NP increased ROS production was inhibited. These results suggest that TiO2 NP‐induced ER stress promotes the generation of ROS, in turn, triggering increased plasma glucose levels in mice. In addition, Res that displays the ability to reduce ER stress presents a dietary polyphenol antioxidant that can effectively prevent the toxicological effects of TiO2 NPs on plasma glucose metabolism.

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Section: Discussionmentioning

confidence: 99%