The equilibration length between spin-polarized edge states in the Quantum Hall regime is measured as a function of a gate voltage applied to an electrode on top of the edge channels. Reproducible fluctuations in the coupling are observed and interpreted as a mesoscopic fingerprint of single spin-flip scatterers which are turned on and off. A model to analyze macroscopic edge state coupling in terms of individual scatterers is developed, and characteristic values for these scatterers in our samples are extracted. For all samples investigated, the distance between spin-flip scatterers lies between the Drude and the quantum scattering length.The unique transport properties of two-dimensional electron gases in the integer Quantum Hall regime [1] can, to a large extent, be explained in a single particle picture by electronic transport via edge channels [2], which carry the current without dissipation over macroscopic distances. The Quantum Hall effect is not influenced by scattering between edge channels running at the same side of the sample. Such scattering, however, does occur and can be detected in various ways, for example by measuring the equilibration between edge channels [3]. In a macroscopic picture, the equilibration between two edge channels can be described by the coupling P , a macroscopic quantity defined by P = (∆µ − ∆µ ′ )/∆µ, where ∆µ and ∆µ ′ are the differences in the electrochemical potential between the edge channels before and after the equilibration along a length L. The equilibration length ℓ eq is then defined by the length over which ∆µ is reduced to 1/e of its initial value, i.e.This picture does not contain information on the microscopic origin of edge state equilibration. However, it is generally accepted that equilibration between spinpolarized edge channels, separated in energy by gµ B B (g is the effective electronic g-factor, µ B the Bohr magneton, and B the magnetic field) takes place via spin-orbit coupling [3], in contrast to the equilibration between edge channels separated in energy by the Landau gap [4]. Impurities provide magnetic field gradients in the reference frame of the moving electrons, which can induce scattering between edge channels of opposite spin. Measurements of the equilibration length over macroscopic distances [5,6] are in agreement with the values obtained from the theory of this spin-orbit coupling mechanism [7][8][9][10][11]. Other possible mechanisms for inter-edge state coupling, for example magnetic impurities, are thought to play only a secondary role in clean Ga[Al]As heterostructures. In a recent work, Polyakov [12] argues that since these spin-flip transitions involve a momentum transfer to the impurity potential, their rate must be suppressed when the disorder is smooth. He concludes that the spinflip scattering is not only very sensitive to the local potential, but also that transitions are induced by rather rare fluctuations which provide a strong scattering potential. It is precisely this picture that we can support by the measurements presented...