Inter and intraspecies genetic differences in survial to an acute hypoxic challenge in mice, rats, quails and chickens

Stupfel, M; Perramon, A.; Mérat, P.; Faure, Jean-Michel; Pesce, Victor Hugo Demaria; Massé, Hélène

doi:10.1016/0300-9629(79)90450-x

Cited by 14 publications

(5 citation statements)

References 11 publications

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“…Gender differences in cardiac arrest frequency and brain outcomes have not been systematically studied in humans, and the majority of animal studies in this area have been conducted exclusively in male ani mals. There are single reports that mortality is lower in female animals treated with hypoxia (Stupfel et al, 1979), drug-induced myocardial in farction (Wexler et al, 1974), and circulatory shock (Altura, 1976). Estrogen is generally considered to be cardioprotective in coronary heart disease, by mechanism(s) yet to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Postischemic Cerebral Blood Flow Recovery in the Female: Effect of 17β-Estradiol

Hurn

Littleton-Kearney

Kirsch

et al. 1995

J Cereb Blood Flow Metab

150

101

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Summary: Female reproductive hormones are consid ered to be protective agents in atherosclerotic vascular disease and stroke. The present study determined if there are unique cerebrovascular responses in female animals to global cerebral ischemia and if 17J3-estradiol is impor tant to postischemic outcome in brain. Three groups of anesthetized, sexually mature rabbits were treated with normotensive four-vessel occlusion (6 min) and 3 h of reperfusion: females chronically instrumented with 1713-estradiol implants (EFEM; n = 8, plasma estradiol level = 365 ± 48 pg/ml), untreated females (FEM; n = 8, estradiol = 13 ± 3 pg/ml), and untreated males (M; n = 8, estradiol < limit of radioimmunoassay). CBF (micro spheres) and somatosensory evoked potential (SEP) am plitude were measured during ischemia/reperfusion. Baseline hemispheric blood flow and regional flow distri-The incidence of atherosclerotic vascular disease in premenopausal women is less than in men, but this difference disappears after menopause (Bush and Miller, 1987; Wolf et aI., 1987; Barrett-Connor and Bush, 199 1; Sivenius et aI. , 199 1). These obser vations have historically been interpreted as evi dence that female reproductive hormones confer vascular protection in ischemic heart disease and stroke. However, it is unclear if estrogen per se is critical to stroke risk or by what mechanism protec tion is achieved. Further, the presence of vascular responses unique to the female in an ongoing cere- 666bution were not altered by chronic estradiol treatment. Hemispheric blood flow was equivalently reduced during ischemia in FEM and M (6 ± 1 and 9 ± 2 ml min -I 100 g-I, respectively); however postischemic hyperemia was greater in FEM than M (CBF = 25 7 ± 27 and 18 3 ± 27 ml min -1 100 g -I. However, EFEM experienced higher CBF during ischemia (e.g., 13 ± 2ml min-1100 g-l) and less hyperemia (134 ± 4 ml min -I 100 g-I in hemi spheres) in numerous brain regions than FEM. CBF at 3 h reperfusion was not different among the groups. Recov ery of SEPs was incomplete and similar in all groups. We conclude that chronic exogenous 17J3-estradiol treatment increases CBF during global incomplete ischemia and ameliorates postischemic hyperemia in the female animal.

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Section: Discussionmentioning

confidence: 99%

Postischemic Cerebral Blood Flow Recovery in the Female: Effect of 17β-Estradiol

Hurn

Littleton-Kearney

Kirsch

et al. 1995

J Cereb Blood Flow Metab

150

101

View full text Add to dashboard Cite

show abstract

Section: Difference Between the Strainsmentioning

confidence: 99%

“…Resistance to acute hypoxic changes varies significantly in the different sexes, strains, and species [39]. The mortality rates of female mice and rats were lower than males following an acute hypoxic challenge [39]. A m o n g gerbils displaying overt neurological signs of hemispheric ischaemia during unilateral carotid occlusion, males demonstrated significantly greater postischaemic neuronal loss in both CA1 and cerebral cortex than females [19].…”

Section: Difference Between the Strainsmentioning

confidence: 99%

“…Although the sex difference of rats significantly influences the survival following acute hypoxia [39], rats from the same strain but different suppliers, or even different shipments of rats from same supplier may vary in their response to an ischaemic insult [32,34]. In this study, both strains were shipped by the same supplier (Charles River Laboratories, Inc. Wilmington MA, USA) and all rats from each strain were delivered on the same shipment.…”

Section: Difference Between the Strainsmentioning

confidence: 99%

“…Differences between the sexes, strains and species significantly influence the experimental results following cerebral ischaemic insults [16,19,32,34,39].…”

Section: Introductionmentioning

confidence: 99%

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Mild hypothermia fails to protect late hippocampal neuronal loss following forebrain cerebral ischaemia in rats

Taşdemiroğlu

1996

Acta neurochir

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Anaesthetized male rats (n = 86) from both Long-Evans strain (LES) (n = 43) and Wistar strain (WS) (n = 43) were utilized for the experiments. While three animals from each strain were used as control, 40 rats from each strain underwent up to 10 minutes forebrain ischaemia by bilateral common carotid artery (CCA) occlusion combined with systemic hypotension [Mean Arterial Blood Pressure (MABP) = 50 mm/Hg]. The animals from each strain were divided into four (n = 10) groups. In both strains, groups (n = 10) 1 and 2, temporalis muscle (TM) and body temperatures of the animals were kept at 36-37 degrees C during the experiments. The groups 1 and 2 were killed in 3 and 7 days after the ischaemic insult, respectively. The groups 3 and 4 were also killed 3 and 7 days after the ischaemic insult, but the forebrain ischaemia was carried out under mild cerebral hypothermia (TM temperature = 33 degrees C). Pyramidal neurons of the hippocampal CA1 region from each group was evaluated semiquantitatively. In WS, groups 1 and 2 showed moderate and severe neuronal loss in the CA1 region, respectively. However, in LES while the group 1 (3 days survival) did not show any neuronal loss, group 2 showed moderate neuronal loss of the CA1 region. While in group 3 (3 days survival, hypothermia) WS and LES, hypothermia protected the CA1 region, group 4 of LES showed mild neuronal loss. However WS, group 4 (7 days survival, hypothermia) showed severe neuronal loss of the CA1 region. It was concluded that mild hypothermia during ischaemic insults did not prevent the delayed postischaemic neuronal damage of the hippocampal CA1 region of both strains, and following 10 minutes forebrain ischaemia, male LES rats were found more resistant than male WS rats to neuronal loss of the CA1 region.

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Phenotypic differences in survival to an experimental acute carbon monoxide intoxication

Stupfel

Pesce

Perrot

1980

Environmental Research

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Inter and intraspecies genetic differences in survial to an acute hypoxic challenge in mice, rats, quails and chickens

Cited by 14 publications

References 11 publications

Postischemic Cerebral Blood Flow Recovery in the Female: Effect of 17β-Estradiol

Postischemic Cerebral Blood Flow Recovery in the Female: Effect of 17β-Estradiol

Mild hypothermia fails to protect late hippocampal neuronal loss following forebrain cerebral ischaemia in rats

Phenotypic differences in survival to an experimental acute carbon monoxide intoxication

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