Recently, more and more robots are being investigated for future applications in health-care. For instance, in nursing assistance, seamless Human-Robot Interaction (HRI) is very important for sharing workspaces and workloads between medical staff, patients, and robots. In this thesis we introduce a novel robot-the Adaptive Robot Nursing Assistant (ARNA) and its underlying components. ARNA has been designed specifically to assist nurses with day-today tasks such as walking patients, pick-and-place item retrieval, and routine patient health monitoring. An adaptive HRI in nursing applications creates a positive user experience, increase nurse productivity and task completion rates, as reported by experimentation with human subjects. ARNA has been designed to include interface devices such as tablets, force sensors, pressure-sensitive robot skins, LIDAR and RGBD camera. These interfaces are combined with adaptive controllers and estimators within a proposed framework that contains multiple innovations. A research study was conducted on methods of deploying an ideal Human-Machine Interface (HMI), in this case a tablet-based interface. Initial study points to the fact that a traded control level of autonomy is ideal for tele-operating ARNA by a patient. The proposed method of using the HMI devices makes the performance of a robot similar for both skilled and unskilled workers. vi