Intensivists and organ donor management

Wood, Kenneth E.; Coursin, Douglas B.

doi:10.1097/aco.0b013e3280895ac8

Cited by 36 publications

(26 citation statements)

References 18 publications

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“…If consent for the donation is obtained, aggressive medical management should be maintained to optimize and treat any physiologic disturbance associated with brain death to protect and optimize organs for transplantation. 106,109 Organ donation after cardiac death may become an option in severely brain injured patients who undergo withdrawal of life sustaining medical supportive care. However, there are specific ethical considerations with donation after cardiac death, and it could compromise the end of life care that is provided to patients.…”

Section: Brain Death and Organ Donationmentioning

confidence: 99%

Neurologic Complications in Non-Neurological Intensive Care Units

Ortega‐Gutiérrez

Wolfe²,

Pandya³

et al. 2009

The Neurologist

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Section: Brain Death and Organ Donationmentioning

confidence: 99%

Neurologic Complications in Non-Neurological Intensive Care Units

Ortega‐Gutiérrez

Wolfe²,

Pandya³

et al. 2009

The Neurologist

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“…86 The use of vasoactive medication is not based on randomized-controlled trials and there are widely divergent opinions concerning the best drugs to use and which to avoid. Most of the discussion is about catecholamines and their anticipated detrimental effects on the donor heart.…”

Section: Hemodynamic Managementmentioning

confidence: 99%

Brain death and its implications for management of the potential organ donor

Bugge

2009

Acta Anaesthesiol Scand

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The systemic physiologic changes that occur during and after brain death affect all organs suitable for transplantation. Major changes occur in the cardiovascular, pulmonary, endocrine, and immunological systems, and, if untreated may soon result in cardiovascular collapse and somatic death. Understanding these complex physiologic changes is mandatory for developing effective strategies for donor resuscitation and management in such a way that the functional integrity of potentially transplantable organs is maintained. This review elucidates these physiological changes and their consequences, and based on these consequences the rationale behind current medical management of brain-dead organ donors is discussed.

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“…It is estimated that over 80% of organ donors require vasoactive support, and about 25% of donor organs are rejected for transplantation due to poor maintenance [6,7]. In a setting of excessive catecholamine stimulation, use of an alpha-agonist vasopressor such as phenylephrine to further stimulate alpha receptor may not be effective in maintaining systemic perfusion pressure.…”

Section: Introductionmentioning

confidence: 99%