“…Only significant results: decrease in the prescriptions of inhaled corticosteroids for newly diagnosed COPD patients older than 40 years: GI 0.0 (95% CI: 0.0-0.1), GC 0.5 (95% CI: 0.3-0.9), p = 0.00. Seven studies assessed the implementation of more than one guideline [13,14,26,32,33,36,37]. In total, two studies assessed the implementation of guidelines on osteoarthritis [19,20,37], four on COPD [13,14,25,33,34], four on hypertension [24,32,36,37], six on coronary heart disease [17,18,23,26,32,36,37], six on asthma [13,14,26,27,30,33,34] and finally seven on type two diabetes mellitus [11,12,15,16,21,22,28,29,31,35].…”