Intensive Polyoma Virus Nephropathy Treatment as a Preferable Approach for Graft Surveillance

Dheir, Hamad; Şahin, Sevgi; Uyar, Murathan; Gürkan, Alp; Turunç, V.; Kaçar, Serdar; Turan, Derya Bayırlı; Başdemir, Gülçin

doi:10.1016/j.transproceed.2011.01.112

Cited by 14 publications

(15 citation statements)

References 34 publications

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“…However, this study did not address how the viral load was changed with the IVIG treatment [25]. Recently, in a study of 4 pediatric kidney recipients, the use of IVIG was reported to be effective for treatment of persistent BKVN after reduction in immunosuppression [28].…”

Section: Discussionmentioning

confidence: 97%

“…Dheir et al [25] reported a study of 19 patients with plasma plus biopsy-proven BKVN in which IVIG treatment was shown to be successful in preventing acute rejection and prolonging graft survival. However, this study did not address how the viral load was changed with the IVIG treatment [25].…”

Section: Discussionmentioning

confidence: 99%

“…The use of IVIG in the treatment of BKVN has increased in recent years among adults [7,15,25] and pediatric transplant recipients [26e28]. The aim of this study was to determine the impact of IVIG on the reduction of the viral load, prevention of acute rejection, and promotion of graft survival among renal transplant recipients with persistent BKVN.…”

mentioning

confidence: 99%

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Efficacy of Intravenous Immunoglobulin in the Treatment of Persistent BK Viremia and BK Virus Nephropathy in Renal Transplant Recipients

Shah

Ansari³

et al. 2015

Transplantation Proceedings

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Efficacy of Intravenous Immunoglobulin in the Treatment of Persistent BK Viremia and BK Virus Nephropathy in Renal Transplant Recipients

Shah

Ansari³

et al. 2015

Transplantation Proceedings

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“…Leflunomide combined with IVIG and decreased immunosuppression resulted in prolonged graft survival in one study of 214 patients 32. Another study showed resolution of BK viraemia in 27/30 patients after addition of IVIG in patients who had inadequate response to reduction in immunosuppression and leflunomide 33.…”

Section: Discussionmentioning

confidence: 99%

Polyomavirus nephropathy of the native kidney in a patient with rheumatoid arthritis and pulmonary fibrosis

et al. 2015

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Polyomavirus nephropathy is commonly seen in the renal allograft setting but is uncommon in native kidneys. This paper describes polyomavirus nephropathy that developed in the native kidneys of a patient following immunosuppressive therapy for rheumatoid arthritis/Sjögren's syndrome associated lung disease. The patient presented with dyspnoea and a slow steady rise in serum creatinine. Owing to chronic immunosuppression, calcineurin-inhibitor toxicity was suspected. However, renal biopsy revealed polyomavirus nephropathy. The treatment of choice, lowered immunosuppression, was complicated by exacerbation of the patient's lung disease. This case highlights features of polyomavirus nephropathy in the native kidney, as well as the difficulty in its treatment when immunosuppressive treatment is necessary for medical comorbidities.

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“…Besides, lowering immunosuppressive regimens together with a specific treatment for BK virus-associated nephropathy recently turns out to be effective to prolong graft survival, and moreover a safe treatment with acute rejection rates not increased significantly after lowering immunosuppression (Dheir et al 2011).…”

Section: Wwwintechopencommentioning

confidence: 99%

Leflunomide an Immunosuppressive Drug for Antiviral Purpose in Treatment for BK Virus-Associated Nephropathy After Kidney Transplantation

Bazin¹

2012

Antiviral Drugs - Aspects of Clinical Use and Recent Advances

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Intensive Polyoma Virus Nephropathy Treatment as a Preferable Approach for Graft Surveillance

Cited by 14 publications

References 34 publications

Efficacy of Intravenous Immunoglobulin in the Treatment of Persistent BK Viremia and BK Virus Nephropathy in Renal Transplant Recipients

Efficacy of Intravenous Immunoglobulin in the Treatment of Persistent BK Viremia and BK Virus Nephropathy in Renal Transplant Recipients

Polyomavirus nephropathy of the native kidney in a patient with rheumatoid arthritis and pulmonary fibrosis

Leflunomide an Immunosuppressive Drug for Antiviral Purpose in Treatment for BK Virus-Associated Nephropathy After Kidney Transplantation

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