2009
DOI: 10.1590/s1807-59322009000100010
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Intensive Perioperative Glucose Control Does Not Improve Outcomes of Patients Submitted to Open-Heart Surgery: A Randomized Controlled Trial

Abstract: BACKGROUND: The objective of this study was to investigate the relationship between different target levels of glucose and the clinical outcomes of patients undergoing cardiac surgery with cardiopulmonary bypass. METHODS: We designed a prospective study in a university hospital where 109 consecutive patients were enrolled during a six-month period. All patients were scheduled for open-heart surgery requiring cardiopulmonary bypass. Patients were randomly alloca… Show more

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Cited by 61 publications
(48 citation statements)
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“…These findings corroborate recent data from other specialties. 2,3,13,23 Acute ischemic stroke and myocardial infarction are both significantly increased among patients who have stress-induced hyperglycemia, irrespective of diabetes status. 2427 It is well known that patients with diabetes have a lower mortality risk when admitted to the hospital than do patients without diabetes who have surges in glycemic index.…”
Section: Discussionmentioning
confidence: 99%
“…These findings corroborate recent data from other specialties. 2,3,13,23 Acute ischemic stroke and myocardial infarction are both significantly increased among patients who have stress-induced hyperglycemia, irrespective of diabetes status. 2427 It is well known that patients with diabetes have a lower mortality risk when admitted to the hospital than do patients without diabetes who have surges in glycemic index.…”
Section: Discussionmentioning
confidence: 99%
“…Our analysis included 14,495 patients from 27 studies 128, 330, 331, 332, 337, 338, 339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 359. None of the studies were especially prone to bias.…”
Section: Cq14: Blood Glucose Managementmentioning
confidence: 99%
“…In Brazil, a study conducted with pa ents undergoing cardiac surgeries iden fi ed similar glycemic means, also no ng a sta s cally signifi cant diff erence (p<0.0016) between the study groups (17) . Considering that the objec ve of the intensive group was to maintain glycemic levels between 80-110mg/dl, and between 180-220mg/dl in the conven onal group, it can be said that the mean glycemic levels obtained in the intensive group approached the expected and the conven onal group remained with results below the range recommended by the protocol.…”
Section: Discussionmentioning
confidence: 75%