Intensive management for raising survival rate of small cell lung cancer (SCLC) with combined multi-therapy including traditional Chinese medicine

Cha, Ren; Li, Weiling; Zheng, Lei; Zeng, Dayong; Li, Weihua

doi:10.1016/s0169-5002(00)80323-2

Cited by 1 publication

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“…Emerging evidence suggests that A. membranaceus has beneficial effects on the immune system, promoting the recovery of patients affected by chemotherapy, radiotherapy [ 16 ], or acquired immune deficiency syndrome [ 17 ]. In particular, the effects of A. membranaceus as an immune enhancer have been partially attributed to its anti-inflammatory and immunomodulatory properties [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Astragalus membranaceus (Fisch.) Bunge Extract in Controlling Inflammatory Response and Preventing Asthma Features

D’Avino

Cerqua

Ullah

et al. 2023

IJMS

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Astragalus membranaceus (Fisch.) Bunge root is used as herbal medicine for its immunomodulating activities in Chinese medicine. Recently, beneficial properties of A. membranaceus on allergic diseases have been proposed. Here we investigated the role of a commercial extract of A. membranaceus, standardized to 16% polysaccharides, in regulating the immune-inflammatory response in vitro and in vivo and its therapeutic application in asthma. A. membranaceus extract inhibited prostaglandin E2 and leukotriene C4 production in stimulated J774 and peritoneal macrophages, respectively. The extract also reduced interlukin-1β, tumor necrosis factor-α, and nitrite production, affecting inducible nitric oxide synthase expression. In vivo experiments confirmed the anti-inflammatory properties of A. membranaceus, as evident by a reduction in zymosan-induced peritoneal cellular infiltration and pro-inflammatory mediator production. The efficacy of A. membranaceus extract in modulating the immune response was confirmed in a model of allergic airway inflammation. Extracts improve lung function by inhibiting airway hyperresponsiveness, airway remodeling, and fibrosis. Its anti-asthmatic effects were further sustained by inhibition of the sensitization process, as indicated by a reduction of ovalbumin-induced IgE levels and the mounting of a Th2 immune response. In conclusion, our data demonstrate the anti-inflammatory properties of the commercial extract of A. membranaceus and its beneficial effects on asthma feature development.

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Section: Discussionmentioning

confidence: 99%