Intensive longitudinal characterization of multidimensional biobehavioral dynamics in laboratory rats

Hasanpour, M; Mitricheva, Ekaterina; Logothetis, Nikos K.; Noori, Hamid

doi:10.1016/j.celrep.2021.108987

Cited by 10 publications

(9 citation statements)

References 91 publications

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“…Given the broad range of temporal scales covered by the dynamic pattern of rhythms, it is important to separate low-frequency high-amplitude from high-frequency low amplitude rhythms. In addition to the circadian rhythm, the first regimen comprises the ~ 12 h circatidal-like rhythm, not only documented in coastal organisms 64 but also in the locomotor activity of quails 23 and rats, as recently shown by Hasanpour and collaborators 65 , whom by comparing the circatidal-like rhythm with the artificial light/dark cycles (12L:12D) using phase-synchronicity analysis observed that the detected circatidal rhythm is unlikely to have been caused by the experimental setup. In addition, herein, we also show evidence of an 8 h rhythm in activity patterns.…”

Section: Discussionmentioning

confidence: 89%

A dynamically coherent pattern of rhythms that matches between distant species across the evolutionary scale

Kembro

Flesia

Nieto

et al. 2023

Sci Rep

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We address the temporal organization of circadian and ultradian rhythms, crucial for understanding biological timekeeping in behavior, physiology, metabolism, and alignment with geophysical time. Using a newly developed five-steps wavelet-based approach to analyze high-resolution time series of metabolism in yeast cultures and spontaneous movement, metabolism, and feeding behavior in mice, rats, and quails, we describe a dynamically coherent pattern of rhythms spanning over a broad range of temporal scales (hours to minutes). The dynamic pattern found shares key features among the four, evolutionary distant, species analyzed. Specifically, a branching appearance given by splitting periods from 24 h into 12 h, 8 h and below in mammalian and avian species, or from 14 h down to 0.07 h in yeast. Scale-free fluctuations with long-range correlations prevail below ~ 4 h. Synthetic time series modeling support a scenario of coexisting behavioral rhythms, with circadian and ultradian rhythms at the center of the emergent pattern observed.

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Section: Discussionmentioning

confidence: 89%

A dynamically coherent pattern of rhythms that matches between distant species across the evolutionary scale

Kembro

Flesia

Nieto

et al. 2023

Sci Rep

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“…It has been well‐known that music played with harmonic notes is the most pleasant to the ears. Like music, biological ultradian rhythms also tend to cycle at the harmonic frequencies of the 24‐h, namely, at the ultradian periods of 12‐h, 8‐h, 6‐h, etc., ranging from the transcriptome, proteome, metabolome to behavior levels 19–32. Interestingly, the harmonic periods usually vary concordantly with the exact period of the circadian rhythm under various physiological conditions.…”

Section: Ultradian Rhythms Predominantly Cycle At the Harmonic Freque...mentioning

confidence: 99%

“…[19,35,46] Superimposed 12-h rhythms of locomotive activity were also reported in both mice and rats under standard laboratory 12-h light/12-h dark conditions. [25,47] Because this is a liver-centric review, we will not elaborate on the topic of 12-h rhythms in extrahepatic tissues, the topic of which was extensively discussed elsewhere. [35,46] Evidence supporting the existence of an XBP1s-dependent 12-h oscillator Several theories have been put forward over the past decade to account for the regulation of hepatic 12-h rhythms.…”

Section: -H Rhythms Of Gene Expression Are Prevalentmentioning

confidence: 99%

“…Like music, biological ultradian rhythms also tend to cycle at the harmonic frequencies of the 24-h, namely, at the ultradian periods of 12-h, 8-h, 6-h, etc., ranging from the transcriptome, proteome, metabolome to behavior levels. [19][20][21][22][23][24][25][26][27][28][29][30][31][32] Interestingly, the harmonic periods usually vary concordantly with the exact period of the circadian rhythm under various physiological conditions. For example, in the MMH-D3 hepatocyte cell line, the free-running first, second and third harmonic periods of gene expression are 21.6 h, 10.8 h, and 7.3 h, respectively.…”

Section: Ultradian Rhythms Predominantly Cycle At the Harmonic Freque...mentioning

confidence: 99%

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Beyond circadian rhythms: emerging roles of ultradian rhythms in control of liver functions

Asher

Zhu

2022

Hepatology

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The mammalian liver must cope with various metabolic and physiological changes that normally recur every day and primarily stem from daily cycles of rest-activity and fasting-feeding. Although a large body of evidence supports the reciprocal regulation of circadian rhythms and liver function, the research on the hepatic ultradian rhythms have largely been lagging behind. However, with the advent of more cost-effective high-throughput omics technologies, highresolution time-lapse imaging, and more robust and powerful mathematical tools, several recent studies have shed new light on the presence and functions of hepatic ultradian rhythms. In this review, we will first very briefly discuss the basic principles of circadian rhythms, and then cover in greater details the recent literature related to ultradian rhythms. Specifically, we will highlight the prevalence and mechanisms of hepatic 12-h rhythms, and 8-h rhythms, which cycle at the second and third harmonics of circadian frequency. Finally, we also refer to ultradian rhythms with other frequencies and examine the limitations of the current approaches as well as the challenges related to identifying ultradian rhythm and addressing their molecular underpinnings.

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“…In addition to liver, wide prevalence of ~12-hour rhythms of gene expression were further identified in murine white adipose tissue, brown adipose tissue, adrenal gland, aorta, muscle and cornea using multiple mathematical/statistical methods (7,(10)(11)(12)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). Using spectrum analytic methods including Fourier, wavelet, autocorrelation analysis and eigenvalue/pencil, ~12-hour rhythms of locomotor activity, energy homeostasis and/or feeding rhythms were also uncovered from rodents (8,11,26).…”

Section: Introductionmentioning

confidence: 99%

Preservation of ∼12-hour ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock

Zhu

Liu

2023

Preprint

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Besides the ~24-hour circadian rhythms, ~12-hour ultradian rhythms of gene expression, metabolism and behaviors exist in animals ranging from crustaceans to mammals. Three major hypotheses were proposed on the origin and mechanisms of regulation of ~12-hour rhythms, namely that they are not cell-autonomous and controlled by a combination of the circadian clock and environmental cues, that they are regulated by two anti-phase circadian transcriptional factors in a cell-autonomous manner, or that they are established by a cell-autonomous ~12-hour oscillator. To distinguish among these possibilities, we performed a post-hoc analysis of two high temporal resolution transcriptome dataset in animals and cells lacking the canonical circadian clock. In both the liver of BMAL1 knockout mice and Drosophila S2 cells, we observed robust and prevalent ~12-hour rhythms of gene expression enriched in fundamental processes of mRNA and protein metabolism that show large convergence with those identified in wild-type mice liver. Bioinformatics analysis further predicted ELF1 and ATF6B as putative transcription factors regulating the ~12-hour rhythms of gene expression independently of the circadian clock in both fly and mice. These findings provide additional evidence to support the existence of an evolutionarily conserved 12-hour oscillator that controls ~12-hour rhythms of gene expression of protein and mRNA metabolism in multiple species.

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Intensive longitudinal characterization of multidimensional biobehavioral dynamics in laboratory rats

Abstract: Highlights d Bistable evolution of rat behavior during development and depends on sex and strain d Big data analysis reveals circatidal-like rhythms in locomotor activity d Thigmotaxic behavior in home-cage may be driven by random walk and not stress

Cited by 10 publications

References 91 publications

A dynamically coherent pattern of rhythms that matches between distant species across the evolutionary scale

A dynamically coherent pattern of rhythms that matches between distant species across the evolutionary scale

Beyond circadian rhythms: emerging roles of ultradian rhythms in control of liver functions

Preservation of ∼12-hour ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock

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