Intensive Locomotor Training Provides Sustained Alleviation of Chronic Spinal Cord Injury-Associated Neuropathic Pain: A Two-Year Pre-Clinical Study

Dugan, Elizabeth; Schachner, Benjamin; Jergová, Stanislava; Sagen, Jacqueline

doi:10.1089/neu.2020.7378

Cited by 16 publications

(29 citation statements)

References 91 publications

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“…Furthermore, after spinal cord contusion in mice, exercise alleviates hyperalgesia and reduces CGRP-immunoreactivity in dorsal horn [675]. In the same line, chronic exercise training also alleviates mechanical and thermal hyperalgesia in mice subjected to spinal cord compression [676].…”

Section: Pathological Pain: Relationship With Sedentary Behavior and ...mentioning

confidence: 85%

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Verdú

Homs

Boadas-Vaello

2021

IJERPH

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A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat body accumulation, triggering structural and functional changes in tissues, organs, and body systems. Research shows that this fat accumulation is responsible for several comorbidities, including cardiovascular, gastrointestinal, and metabolic dysfunctions, as well as pathological pain behaviors. These health concerns are related to the crosstalk between adipose tissue and body systems, leading to pathophysiological changes to the latter. To deal with these health issues, it has been suggested that physical exercise may reverse part of these obesity-related pathologies by modulating the cross talk between the adipose tissue and body systems. In this context, this review was carried out to provide knowledge about (i) the structural and functional changes in tissues, organs, and body systems from accumulation of fat in obesity, emphasizing the crosstalk between fat and body tissues; (ii) the crosstalk between fat and body tissues triggering pain; and (iii) the effects of physical exercise on body tissues and organs in obese and non-obese subjects, and their impact on pathological pain. This information may help one to better understand this crosstalk and the factors involved, and it could be useful in designing more specific training interventions (according to the nature of the comorbidity).

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Section: Pathological Pain: Relationship With Sedentary Behavior and ...mentioning

confidence: 85%

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Verdú

Homs

Boadas-Vaello

2021

IJERPH

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“…Systemic inflammation is key to chronic SCI (Diaz et al, 2021). Systemic inflammatory markers, such as c-reactive protein (CRP) and IL-6, are increased after chronic SCI (Hart et al, 2016;Lynch et al, 2017;Dugan et al, 2021). Chronic SCI can intensify IL-2 and TNF-α levels to upregulate the NF-κB transcriptional activity (Yarar-Fisher et al, 2016).…”

Section: The Role Of Inflammatory Reaction In Chronic Spinal Cord Injurymentioning

confidence: 99%

The Repression of the HMGB1-TLR4-NF-κB Signaling Pathway by Safflower Yellow May Improve Spinal Cord Injury

2021

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Spinal cord injury (SCI) often results in abnormal sensory and motor functions. Current interventions for SCI in the clinical setting are not effective partly due to the complexity concerning its pathophysiological mechanism. In the wake of SCI, considerable inflammatory cells assemble around the injured area that induces a series of inflammatory reactions and aggravates tissue lesions, thereby affecting the recovery of the damaged nerve tissue. Therefore, the inhibition of inflammatory responses can improve the repair of the injured spinal cord tissue. Safflower Yellow (SY) is the main active ingredient of Carthamus tinctorius. SY has anti-inflammatory effect, as it can inhibit IκBα phosphorylation to impede the NF-κB signaling pathway and p53 nuclear translocation. Besides, SY can limit the release of pro-inflammatory factors, which in turn may alleviate secondary SCI and prevent further complications. In this report, we analyze the pathophysiological mechanism of SCI, the role of inflammatory responses, and how SY interferes with the HMGB1-TLR-4-NF-κB signaling pathway to attenuate inflammatory responses in SCI.

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Section: Discussionmentioning

confidence: 99%

“…In one experiment, long-term regular exercise was explored as a means to reduce the neuroanalgesic behavior of mice and, ultimately, promote motor function [52]. Another study investigated the efficacy and functional recovery of SCI neuropathic pain symptoms by using long-term intensive locomotor training [53]. Neural Plasticity years of data extracted from WoS and analyzed by CiteSpace and, thus, provides strong evidence of the future development of research in this field through keywords and subject categories.…”

Section: Research Hot Spots and Trendsmentioning

confidence: 99%

Global Research on Neuropathic Pain Rehabilitation over the Last 20 Years

2021

Neural Plasticity

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Background. Neuropathic pain has long been a very popular and productive field of clinical research. Neuropathic pain is difficult to cure radically because of its complicated etiology and uncertain pathogenesis. As pain worsens and persists, pain recovery techniques become more important, and medication alone is insufficient. No summary of bibliometric studies on neuropathic pain rehabilitation is yet available. The purpose of the present study is to analyze in a systematic manner the trends of neuropathic pain rehabilitation research over the period of 2000–2019. Methods. Studies related to neuropathic pain rehabilitation and published between January 2000 and December 2019 were obtained from the Science Citation Index-Expanded of Web of Science. No restrictions on language, literature type, or species were established. CiteSpace V and Microsoft Excel were used to capture basic information and highlights in the field. Results. Linear regression analysis showed that the number of publications on neuropathic pain rehabilitation significantly increased over time ( P < 0.001 ). The United States showed absolute strength in terms of number of papers published, influence, and cooperation with other countries. Based on the subject categories of the Web of Science, “Rehabilitation” had the highest number of published papers (446), the highest number of citations (10,954), and the highest number of open-access papers (151); moreover, this category and “Clinical Neurology” had the same H -index (i.e., 52). “Randomized Controlled Trials” revealed the largest cluster in the cocitation map of references. The latest burst keywords included “Exercise” (2014–2019), “Functional Recovery” (2015–2019), and “Questionnaire” (2015–2019). Conclusion. This study provides valuable information for neuropathic pain rehabilitation researchers seeking fresh viewpoints related to collaborators, cooperative institutions, and popular topics in this field. Some new research trends are also highlighted.

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Intensive Locomotor Training Provides Sustained Alleviation of Chronic Spinal Cord Injury-Associated Neuropathic Pain: A Two-Year Pre-Clinical Study

Cited by 16 publications

References 91 publications

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

The Repression of the HMGB1-TLR4-NF-κB Signaling Pathway by Safflower Yellow May Improve Spinal Cord Injury

Global Research on Neuropathic Pain Rehabilitation over the Last 20 Years

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