Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study

New glycemic targets for patients with diabetes from the Japan Diabetes Society

“…In this regard, supportive evidence was available from the Kumamoto Study1, in which patients with HbA1c <6.9% were found to be less likely to develop microangiopathy.…”

ADVANCE: action in diabetes and vascular disease

“…17 A number of randomised clinical trials have reported that patients with Type II diabetes assigned to more intensive glucose lowering exhibited greater reductions in the incidence of microvascular events. [18][19][20] However, even in the largest of these trials, the effects of glycaemic control on the risk of macrovascular disease remain inconclusive. 20 …”

Transgene and islet cell delivery systems using nano-sized carriers for the treatment of diabetes mellitus

“…The prevalence of diabetes mellitus is increasing globally, with the number of adults with diabetes mellitus having increased from 108 million in 1980 to 422 million in 2014 [1]. Diabetes mellitus increases the risk for the development of various diseases, including cardiovascular diseases, stroke, neuropathy, retinopathy, and nephropathy [2,3]. It is important that blood glucose levels are maintained so patients do not develop complications associated with diabetes mellitus [2,3].…”

“…Diabetes mellitus increases the risk for the development of various diseases, including cardiovascular diseases, stroke, neuropathy, retinopathy, and nephropathy [2,3]. It is important that blood glucose levels are maintained so patients do not develop complications associated with diabetes mellitus [2,3]. Various small molecules and peptides that can decrease blood glucose levels have been developed and used in clinical settings for patients with diabetes mellitus.…”