1983
DOI: 10.1016/0360-3016(83)90368-1
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Intensive combined modality therapy including low-dose TBI in high-risk ewing's sarcoma patients

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Cited by 38 publications
(6 citation statements)
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“…Total body irradiation and single agent chemotherapy have been used as high-dose therapy but was relatively ineffective in controlling advanced disease [13][14][15][16][17][18]. However, TBI-containing myeloablative regimens have been reported to improve EFS of high-risk ES [1,[19][20][21][22]. Burdach et al reported a 6-year EFS of 45% for patients who received HDC and TBI followed by stem cell rescue compared to 2% for the historical control group of patients who were treated with chemotherapy only [8].…”
Section: Discussionmentioning
confidence: 99%
“…Total body irradiation and single agent chemotherapy have been used as high-dose therapy but was relatively ineffective in controlling advanced disease [13][14][15][16][17][18]. However, TBI-containing myeloablative regimens have been reported to improve EFS of high-risk ES [1,[19][20][21][22]. Burdach et al reported a 6-year EFS of 45% for patients who received HDC and TBI followed by stem cell rescue compared to 2% for the historical control group of patients who were treated with chemotherapy only [8].…”
Section: Discussionmentioning
confidence: 99%
“…Treatment protocols used at the NCI for Ewing's sarcoma have been described previously. 19v24, 25 All protocols included radiation therapy to the entire bone and any soft tissue extension and chemotherapy with various combinations of vincristine, dactinomycin, doxorubicin, and cyclophosphamide. Based on the intensity of the combined therapy and for the purposes of statistical analyses, the protocols were grouped as early (Sl, S2, and S3; 1968 through 1972), mid (S4; 1972 through 1977), and recent (S5, S6, S7, S8, S9; 1977 through 1984).…”
Section: Clinical Correlationmentioning
confidence: 99%
“…Another treatment intensification strategy in Ewing's sarcoma is high-dose chemotherapy with autologous hematopoietic stem cell rescue (HDT) [113]. Because of the considerable toxicity of this approach, most studies investigate HDT for very high risk patients, most commonly those with metastatic disease at diagnosis, or following recurrence [77,[114][115][116]. A controlled, randomized study of HDT in Ewing's sarcoma has recently been undertaken in the www.TheOncologist.com framework of the EURO-E.W.I.N.G.…”
Section: Chemotherapymentioning
confidence: 99%