INTENSIVE CARE IN RABIES THERAPY Clinical Observations

Gode, G. R.; Jayalakshmi, T; Raju, Aghosh; Kaul, H. L.; Bhide, N K

doi:10.1016/s0140-6736(76)92965-2

Cited by 33 publications

(13 citation statements)

References 3 publications

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“…Rabies experts have recommended that the approach to rabies encephalitis management be only palliative. The following characteristics and resources could be considered favorable for an aggressive therapy: administration of any rabies vaccine before the clinical onset of rabies; manifestation of the disease at a very early stage, with minimal neurological symptoms or signs; previously good health and absence of chronic diseases; relatives who accept both the high probability of an unsuccessful outcome and the possibility of neurological disability in a rabies survivor; and access to appropriate resources and facilities (38). barbiturates (GABA-receptor agonists and induced therapeutic coma reduce the brain excitatory metabolism and autonomic reactivity).…”

Section: Management Of Rabies In Humansmentioning

confidence: 99%

Rabies review: immunopathology, clinical aspects and treatment

Consales¹,

Bolzan²

2007

J. Venom. Anim. Toxins incl. Trop. Dis

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Among the diseases of viral origin, rabies is unique in its distribution and range of victims since it can afflict all warm-blooded animals. The interaction between the virus and the host population has facilitated the survival of the disease.The rabies virus (RV) has not changed in any significant way and has been capable of taking advantage of conditions suited to the continuance of rabies. Infection by RV is invariably lethal in the absence of protective immune response which, however, can contribute to the pathogenesis of rabies. Proinflammatory cytokines might affect, directly or indirectly, the levels of neurotrophins, growth factors, neurotransmitters and neurotoxins in the brain by activating glia, neurons, and vascular and immune cells. Although understanding of the bases for neuronal dysfunction and neuronal death during RV infection has progressed, no fundamental abnormality has been identified so far.

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Section: Management Of Rabies In Humansmentioning

confidence: 99%

Rabies review: immunopathology, clinical aspects and treatment

Consales¹,

Bolzan²

2007

J. Venom. Anim. Toxins incl. Trop. Dis

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“…5,6 However, there are six well-documented cases of recovery from rabies in the literature after the clinical presentation developed. 7 In this paper, we present the first human case who recovered from clinical rabies after the development of clinical picture and whose diagnosis was confirmed by direct diagnostic methods.…”

mentioning

confidence: 99%

Complete Recovery from Clinical Rabies: Case Report

Karahocagil¹,

Akdeniz²,

Aylan³

et al. 2013

Turkiye Klinikleri J Med Sci

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“…The use of steroids as adjunctive therapy continues to be controversial, although a number of reports have shown clinical benefits. Novel methods have been recently proposed for viral identification; thus it is hoped that random DNA amplification coupled to other molecular techniques [87,88] will allow detection of the multiple agents of encephalitis. Much needs to be done to improve the prognosis of viral encephalitis.…”

Section: Discussionmentioning

confidence: 99%

“…Although survival has been reported in isolated cases of symptomatic patients, all of those patients had received either pre-or postexposure prophylaxis and none had positive test results for rabies virus [87][88][89][90][91][92]. Disabling neurologic sequelae followed in nearly all of these survivors.…”

Section: Managementmentioning

confidence: 99%

Viral Encephalitis: Etiology, Clinical Features, Diagnosis and Management

Ferrari

Toniolo

Monaco

et al. 2009

TOIDJ

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Viral encephalitis is worldwide spread pathology with high morbidity and mortality. Its incidence is higher in children. Enteroviruses, varicella zoster virus and herpes simplex viruses are the most frequent agents. However, in spite of the use of modern microbiological and radiological methods, an etiological diagnosis is reached in less than 50% of cases, making a careful differential diagnosis with non viral brain diseases imperative. Pathogenesis is elusive and therapy continues to remain supportive in almost all cases, as the only virus-directed treatment is available for herpesvirus-related encephalitis and a role for steroids continues to be debated. Novel and more targeted therapies are eagerly needed.

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INTENSIVE CARE IN RABIES THERAPY Clinical Observations

Cited by 33 publications

References 3 publications

Rabies review: immunopathology, clinical aspects and treatment

Rabies review: immunopathology, clinical aspects and treatment

Complete Recovery from Clinical Rabies: Case Report

Viral Encephalitis: Etiology, Clinical Features, Diagnosis and Management

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