Intensity of the Humoral Response to Cytomegalovirus Is Associated with the Phenotypic and Functional Status of the Immune System

Brief Report: Soluble CD163 in CMV-Infected and CMV-Uninfected Subjects on Virologically Suppressive Antiretroviral Therapy in the ICONA Cohort

“…1,6 Furthermore, to evaluate the correlation between monocyte activation markers and the magnitude of CMV-specific immune response, we measured anti-CMV IgG plasma level. Despite the limitations of serologic studies, many evidence suggested that CMV IgG persist overtime also in settings of immunodeficiency 35 and are associated with hyperactivated/ senescent T cell, 36 atherosclerosis/cardiovascular disease, 6 and neurocognitive impairment, 37 all suggesting that CMVspecific immunity may be involved, at least partially, in disease immunopathogenesis.…”

Frequent participation in high volume exercise throughout life is associated with a more differentiated adaptive immune response

“…IRP may be summarized by the presence of an inverted CD4/CD8 ratio, expanded populations of CD8+CD28 null memory T-cells, and CMV seropositivity (Olsson et al, 2000). Recently, it has been reported that not only the CMV infection but also the titer of CMV-specific antibodies is crucial for determining the higher T-cell differentiation degree and the risk of increased mortality Alonso-Arias et al, 2013;Roberts et al, 2012;Strandberg et al, 2009). In our study, differences due to activity level were found even after adjusting comparisons for CMV serological status.…”

Aging and Options to Halt Declining Immunity to Virus Infections

“…The mechanisms involved in HCMV latency are still poorly understood and despite extensive literature on how HCMV infection influences the adaptive immune response in older adults, this is still a matter of debate (254). Immunologically, HCMV infection is characterized by inflation of HCMV-specific memory T cells, mostly CD8 + , with proliferation of oligoclonal T cells (96,(255)(256)(257)(258)(259)(260)(261)(262). The accumulation of these terminally differentiated apoptosis-resistant CMV-specific T cells clones is believed to compromise the overall T cell repertoire diversity.…”