Intensity-modulated radiotherapy prolongs the survival of patients with nasopharyngeal carcinoma compared with conventional two-dimensional radiotherapy: A 10-year experience with a large cohort and long follow-up

Zhang, Mengxia; Li, Jing; Shen, Guo‐Ping; Zou, Xiong; Xu, Junjie; Jiang, Rou; You, Rui; Hua, Yi-Jun; Sun, Ying; Ma, Jun; Hong, Ming; Chen, Ming‐Yuan

doi:10.1016/j.ejca.2015.08.006

Cited by 253 publications

(226 citation statements)

References 20 publications

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“…The trial showed similar OS and DFS between IC and CC but more acute toxicities from CC. As IMRT can achieve better LRFS and OS than 2DCRT [33], it is less likely to observe significant differences between IC and CC in the IMRT era. This trial strongly supported the outcomes of our present study despite the differences in chemotherapy regimens and the addition of AC in both arms.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of Induction Chemotherapy Plus Intensity-Modulated Radiotherapy (IMRT) Versus IMRT Plus Concurrent Chemotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma: A Propensity Matched Study

Ou-Yang

Zhang

et al. 2016

Translational Oncology

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PURPOSE: It deserves investigation whether induction chemotherapy (IC) followed by intensity-modulated radiotherapy (IMRT) is inferior to the current standard of IMRT plus concurrent chemotherapy (CC) in locoregionally advanced nasopharyngeal carcinoma. METHODS: Patients who received IC (94 patients) or CC (302 patients) plus IMRT at our center between March 2003 and November 2012 were retrospectively analyzed. Propensity-score matching method was used to match patients in both arms at equal ratio. Failure-free survival (FFS), overall survival (OS), distant metastasis–free survival (DMFS), and locoregional relapse–free survival (LRFS) were assessed with Kaplan-Meier method, log-rank test, and Cox regression. RESULTS: In the original cohort of 396 patients, IC plus IMRT resulted in similar FFS (P = .565), OS (P = .334), DMFS (P = .854), and LRFS (P = .999) to IMRT plus CC. In the propensity-matched cohort of 188 patients, no significant survival differences were observed between the two treatment approaches (3-year FFS 80.3% vs 81.0%, P = .590; OS 93.4% vs 92.1%, P = .808; DMFS 85.9% vs 87.7%, P = .275; and LRFS 93.1% vs 92.0%, P = .763). Adjusting for the known prognostic factors in multivariate analysis, IC plus IMRT did not cause higher risk of treatment failure, death, distant metastasis, or locoregional relapse. CONCLUSIONS: IC plus IMRT appeared to achieve comparable survival to IMRT plus CC in locoregionally advanced nasopharyngeal carcinoma. Further investigations were warranted.

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Section: Discussionmentioning

confidence: 99%

Outcomes of Induction Chemotherapy Plus Intensity-Modulated Radiotherapy (IMRT) Versus IMRT Plus Concurrent Chemotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma: A Propensity Matched Study

Ou-Yang

Zhang

et al. 2016

Translational Oncology

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“…However, the results of this approach were unsatisfactory in the era of two-dimensional conventional radiotherapy (2D-CRT). The 5-year overall survival (OS) is only 67-76%, and loco-regional recurrence and distant metastasis are the main causes of treatment failure, with an incidence of 13.5-35.6% and 19.6-27.6% (Yi et al 2006;Peng et al 2012;Zhang et al 2015), respectively. In recent years, intensity-modulated radiotherapy (IMRT) has replaced 2D-CRT as the first choice for the treatment of NPC.…”

Section: Introductionmentioning

confidence: 99%

The value of the Prognostic Nutritional Index (PNI) in predicting outcomes and guiding the treatment strategy of nasopharyngeal carcinoma (NPC) patients receiving intensity-modulated radiotherapy (IMRT) with or without chemotherapy

Miao

Xiao

Wang

et al. 2017

J Cancer Res Clin Oncol

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“…In recent decades, high-precision radiation therapy, including IMRT, has been developed. As this therapy can deliver a highly conformal dose to the target with minimal exposure to adjacent normal tissues, it can significantly reduce toxicity and improve disease control (24,25). It could be emphasized that radiotherapy is a considerable treatment option for MPS.…”

Section: Literature Review and Discussionmentioning

confidence: 99%

Malignant psoas syndrome associated with gynecological malignancy: Three case reports and a review of the literature

et al. 2018

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Abstract. Malignant psoas syndrome (MPS) is a rare and unique cancer-associated syndrome caused by the malignant involvement of the psoas major muscle, and is characterized by ipsilateral lumbosacral plexopathy and painful hip flexion. The pain in MPS is often distressing and intractable, and there is no established effective treatment approach. Herein, the present study reports on three cases of MPS associated with gynecological malignancies, wherein symptom improvement was observed following chemotherapy or radiotherapy. Among 39 cases documented in the literature, female genital tract malignancies were the most frequent causes of MPS; however, the condition may be under-diagnosed, owing to the lack of general recognition. Considering the development of recent high-precision radiation therapy, palliative radiotherapy may serve an important role in the management of MPS. For physicians treating gynecological cancers, early detection of MPS is clinically important as this may allow patients to receive possible therapies and improve their quality of life in end-stage cancer. Further prospective studies should be performed to evaluate effective therapeutic approaches for MPS.

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Intensity-modulated radiotherapy prolongs the survival of patients with nasopharyngeal carcinoma compared with conventional two-dimensional radiotherapy: A 10-year experience with a large cohort and long follow-up

Cited by 253 publications

References 20 publications

Outcomes of Induction Chemotherapy Plus Intensity-Modulated Radiotherapy (IMRT) Versus IMRT Plus Concurrent Chemotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma: A Propensity Matched Study

Outcomes of Induction Chemotherapy Plus Intensity-Modulated Radiotherapy (IMRT) Versus IMRT Plus Concurrent Chemotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma: A Propensity Matched Study

The value of the Prognostic Nutritional Index (PNI) in predicting outcomes and guiding the treatment strategy of nasopharyngeal carcinoma (NPC) patients receiving intensity-modulated radiotherapy (IMRT) with or without chemotherapy

Malignant psoas syndrome associated with gynecological malignancy: Three case reports and a review of the literature

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