Intensity Modulated Radiotherapy for Tumors of the Nasal Cavity and Paranasal Sinuses: Clinical Outcomes and Patterns of Failure

Wiegner, E.; Daly, Megan E.; Chapman, Christopher H.; Yu, Yao; Colevas, A.D.; Kaplan, Michael; Fischbein, Nancy J.; Le, Quynh Thu; Chang, Daniel T.

doi:10.1016/j.ijrobp.2010.07.1086

Cited by 18 publications

(34 citation statements)

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“…Other negative prognostic factors for nasal cavity and paranasal sinuses include advanced N classification, intracranial tumor infiltration, or infiltration of the pterygopalatine fossa, skull base, dura, cribriform plate, or orbits …”

Section: Introductionmentioning

confidence: 99%

ACR appropriateness criteria^® nasal cavity and paranasal sinus cancers

et al. 2016

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The American College of Radiology (ACR) Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer-reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment. Here, we present the Appropriateness Criteria for cancers arising in the nasal cavity and paranasal sinuses (maxillary, sphenoid, and ethmoid sinuses). This includes clinical presentation, prognostic factors, principles of management, and treatment outcomes. Controversies regarding management of cervical lymph nodes are discussed. Rare and unusual nasal cavity cancers, such as esthesioneuroblastoma and sinonasal undifferentiated carcinomas, are included. © 2016 American College of Radiology. Head Neck, 2016 © 2016 Wiley Periodicals, Inc. Head Neck 39: 407-418, 2017.

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Section: Introductionmentioning

confidence: 99%

ACR appropriateness criteria^® nasal cavity and paranasal sinus cancers

et al. 2016

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“…IMRT is effective to deliver high doses to target volumes while limiting the dose to adjacent critical structures [12]. We found 7 other single center retrospective studies reporting comparable local control (49-87%) and overall survival data of 45-100% at 2-5 years with low rate of toxicity in patients with sinunasal cancer [7][8][9][10][11][12]15]. Most IMRT series did not observe any grade 3 visual impairment [8][9][10][11].…”

Section: Discussionmentioning

confidence: 92%

“…21% of patients treated with RT only experienced complications which resolved without intervention [2]. IMRT is effective to deliver high doses to target volumes while limiting the dose to adjacent critical structures [12]. We found 7 other single center retrospective studies reporting comparable local control (49-87%) and overall survival data of 45-100% at 2-5 years with low rate of toxicity in patients with sinunasal cancer [7][8][9][10][11][12]15].…”

Section: Discussionmentioning

confidence: 94%

“…IMRT studies dealing with a heterogeneous patient collective including paranasal sinus cancers were applying systemic therapy in 0 to and 17% [7][8][9][10][11]15]. Wiegner et al applied chemotherapy in a sub collective of patients with nasal cancer in 36% [12]. In our study collective systemic therapy was given in 54%.…”

Section: Discussionmentioning

confidence: 98%

“…They revealed excellent local control rates with minimized toxicity [7][8][9][10][11][12]. In those series only a minority of included patients were diagnosed with nasal cavity or nasal vestibule tumors.…”

Section: Introductionmentioning

confidence: 99%

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IMRT for Nasal Tumors – Local Control and Cosmetic Outcome

Glanzmann¹,

Holzmann²,

Studer

2014

J Nucl Med Radiat Ther

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Exploratory study of the association of volumetric modulated arc therapy (VMAT) plan robustness with local failure in head and neck cancer

Liu

Patel

Harrington

et al. 2017

J Applied Clin Med Phys

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This work is to show which is more relevant to cause local failures (LFs) due to patient setup uncertainty between the planning target volume (PTV) underdosage and the potential target underdosage subject to patient setup uncertainties in head and neck (H&N) cancer treated with volumetric‐modulated arc therapy (VMAT). Thirteen LFs in 10 H&N patients treated by VMAT were analyzed. Measures have been taken to minimize the chances of insufficient target delineation for these patients and the patients were clinically determined to have LF based on the PET/CT scan results by an experienced radiologist and then reviewed by a second experienced radiation oncologist. Two methods were used to identify the possible locations of LF due to underdosage: (a) examining the standard VMAT plan, in which the underdosed volume in the nominal dose distribution (UVN) was generated by subtracting the volumes receiving the prescription doses from PTVs, and (b) plan robustness analysis, in which in addition to the nominal dose distribution, six perturbed dose distributions were created by translating the CT iso‐center in three cardinal directions by the PTV margin. The coldest dose distribution was represented by the minimum of the seven doses in each voxel. The underdosed volume in the coldest dose distribution (UVC) was generated by subtracting the volumes receiving the prescription doses in the coldest dose distribution from the volumes receiving the prescription doses in the nominal dose distribution. UVN and UVC were subsequently examined for spatial association with the locations of LF. The association was tested using the binominal distribution and the Fisher's exact test of independence. We found that of 13 LFs, 11 were associated with UVCs (P = 0.011), while three were associated with UVNs (P = 0.99). We concluded that the possible target underdosage due to patient setup uncertainties appeared to be a more relevant factor associated with LF in VMAT for H&N cancer than the compromised PTV coverage at least for the patients included in this study.

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Intensity Modulated Radiotherapy for Tumors of the Nasal Cavity and Paranasal Sinuses: Clinical Outcomes and Patterns of Failure

Cited by 18 publications

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ACR appropriateness criteria^® nasal cavity and paranasal sinus cancers

ACR appropriateness criteria^® nasal cavity and paranasal sinus cancers

IMRT for Nasal Tumors – Local Control and Cosmetic Outcome

Exploratory study of the association of volumetric modulated arc therapy (VMAT) plan robustness with local failure in head and neck cancer

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Intensity Modulated Radiotherapy for Tumors of the Nasal Cavity and Paranasal Sinuses: Clinical Outcomes and Patterns of Failure

Cited by 18 publications

References 0 publications

ACR appropriateness criteria® nasal cavity and paranasal sinus cancers

ACR appropriateness criteria® nasal cavity and paranasal sinus cancers

IMRT for Nasal Tumors – Local Control and Cosmetic Outcome

Exploratory study of the association of volumetric modulated arc therapy (VMAT) plan robustness with local failure in head and neck cancer

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Product

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ACR appropriateness criteria^® nasal cavity and paranasal sinus cancers

ACR appropriateness criteria^® nasal cavity and paranasal sinus cancers