Intensity-modulated radiation therapy for the treatment of nonanaplastic thyroid cancer

Rosenbluth, Benjamin; Serrano, Victoria; Happersett, Laura; Shaha, Ashok R.; Tuttle, R. Michael; Narayana, Ashwatha; Wolden, Suzanne L.; Rosenzweig, Kenneth E.; Chong, Lanceford M.; Lee, Nancy Y.

doi:10.1016/j.ijrobp.2005.05.043

Cited by 75 publications

(40 citation statements)

References 7 publications

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“…However, one must consider the potentially suboptimal 30 Gy doses applied compared with the 60-70 Gy used more recently. 47,48 Lower doses were used historically because older radiotherapy methods could not deliver an adequate dose of radiation to the thyroid bed without exceeding the tolerance of the posteriorly located spinal cord. In 2003, Ford et al reported that local recurrence and OS are related to the dose prescribed, based on a small cohort (n = 41), suggesting a dose of a least 50 Gy is needed to impact local control and possibly survival.…”

Section: External Beam Radiation Therapy (Ebr)mentioning

confidence: 99%

Long-Term Follow-Up After Complete Resection of Well-Differentiated Cancer Confined to the Thyroid Gland

et al. 2009

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Background. Papillary or follicular thyroid carcinomas exhibit a relatively benign course. Hence, long-term follow-up studies with well-defined disease stages and treatment details are needed to evaluate treatment strategies. Methods. Patients who underwent complete resection of well-differentiated thyroid carcinoma (WDTC) confined to the thyroid gland between 1972 and 1990 identified from a prospective database were assessed. Follow-up was performed by interview, review of patient charts, and analysis of the Death Registry. Primary endpoints were overall survival (OS) and disease-specific survival (DSS). Review of histology was performed and extent of thyroid resection, postoperative therapy, and recognized prognostic factors but not lymphadenectomy were evaluated. Results. Of 2,867 patients, 213 had complete resection of WDTC confined to the thyroid gland. Follow-up was completed in 166 patients with median age 54.2 (range, 20-85) years, and median follow-up of 27.2 (range, 15.6-34.5) years. The 10-and 20-year OS was 71 and 55%, respectively. DSS at 10 and 20 years was 81 and 69%, respectively, and correlated with age, histology, tumor size, radio-iodide ablation (RIA), and external beam irradiation (EBR) treatment. No patient died of WDTC more than 18 years after resection. Total or near-total thyroidectomy without lymphadenectomy was not superior to partial thyroidectomy. In multivariate analysis for DSS, age was the dominant factor, which correlated with histology.

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Section: External Beam Radiation Therapy (Ebr)mentioning

confidence: 99%

Long-Term Follow-Up After Complete Resection of Well-Differentiated Cancer Confined to the Thyroid Gland

et al. 2009

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“…A wide spectrum of EBRT doses has been used in the treatment of PTC, ranging from 30 Gy in the older series to 70 Gy more recently (Sheline et al 1966, Rosenbluth et al 2005. Studies included patients with either gross or microscopic residual disease, which confounds the interpretation of the findings.…”

Section: Radiotherapy Dose For Ptcmentioning

confidence: 99%

The role of external beam radiotherapy in the treatment of papillary thyroid cancer

Lee¹,

Tuttle²

2006

Endocr Relat Cancer

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The role of external beam radiotherapy (EBRT) in treating thyroid cancer has brought forth controversy. Due to various histologic presentations and different natural histories, there is no uniform approach/recommendation among centers and/or authorities regarding the role of EBRT for thyroid cancer. This is particularly true for papillary thyroid carcinoma (PTC) where the clinical course can range from a disease that is cured with simple surgery to an aggressive form of poorly differentiated thyroid cancer with high rates of recurrence/death from disease. In addition, because the majority of the patients with PTC undergo postoperative radioactive iodine (RAI) treatment, the question remains as to what is the exact role of EBRT for PTC in the setting of RAI treatment?In this issue of Endocrine-Related Cancer, Chow and colleagues identified indications for EBRT and RAI therapy for PTC based on a retrospective review of 1300 patients. The authors concluded that postoperative RAI treatment is indicated in patients with pT2-pT4, pN0-pN1b while postoperative EBRT is recommended for patients with gross residual, positive margin, pT4, pN1b, and lymph nodes O2 cm disease. Other centers have also published their experience on the value of EBRT for PTC but with different indications. The reasons for the variations from different centers are complex. However, when all published results are taken together, the findings confirm the added value of EBRT to the present management of PTC in a select group of patients, particularly those with high risk features. In this commentary, these issues will be discussed and recommendations regarding the role of EBRT will be given.

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“…On the other hand, when combined with surgery and chemotherapy, it can prolong the short-term survival in select and subset of patients. Intensity-modulated radiation therapy (IMRT) based on computerized treatment planning and delivery is able to generate a dose distribution that delivers radiation accurately with sparing of the surrounding normal tissue [17,18]. A report from MD Anderson Cancer Center compared outcomes for ATC patients treated with conformal 3-dimensional radiotherapy (3DRT) or IMRT.…”

Section: Radiotherapymentioning

confidence: 99%

Rapid Recurrence of Anaplastic Carcinoma: Advocacy towards Non-Surgery

Habra¹

2017

EMIJ

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DiscussionThe majority of anaplastic cancers are revealed by the rapid transformation of an old goitre: increase in volume, pain, dysphonia, dyspnea by tracheal compression and dysphagia thereafter. The nodal invasions, the repercussion on the general state, immediately sign the gravity of the situation. The cervical ultrasound is not specific but allows suspecting a malignant AbstractAnaplastic carcinoma of the thyroid (ATC) is a rare but aggressive tumor, its prognosis is dark. Most patients diagnosed with this disease are 65 years of age or older, treatment is based on the combined action of radiotherapy, chemotherapy and surgical removal when possible. We report a case of anaplastic carcinoma of the thyroid which has been thundering in postoperative surgery after total thyroidectomy, this case highlights the ineffectiveness of surgery in the reduction of tumor mass. Surely contribute to a historical recurrence and aggravate the prognosis. We will study through a review of the literature the clinical aspects and discuss the therapeutic modalities of this cancer.Keywords: Anaplastic thyroid carcinoma; Therapeutic modalities

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Intensity-modulated radiation therapy for the treatment of nonanaplastic thyroid cancer

Cited by 75 publications

References 7 publications

Long-Term Follow-Up After Complete Resection of Well-Differentiated Cancer Confined to the Thyroid Gland

Long-Term Follow-Up After Complete Resection of Well-Differentiated Cancer Confined to the Thyroid Gland

The role of external beam radiotherapy in the treatment of papillary thyroid cancer

Rapid Recurrence of Anaplastic Carcinoma: Advocacy towards Non-Surgery

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