Intensity-modulated Radiation Therapy for Children with Intraocular Retinoblastoma:Potential Sparing of the Bony Orbit

Krasin, Matthew J.; Crawford, B; Zhu, Yun; Evans, Elin; Sontag, Marc R.; Kun, Larry E.; Merchant, Thomas E.

doi:10.1016/j.clon.2003.11.008

Cited by 47 publications

(26 citation statements)

References 28 publications

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“…39 Newer RT modalities, such as IMRT and proton beam therapy, may enhance protection of normal tissues. 40,41 Some children with metastatic RB, involving the bone marrow and bones, may be cured by aggressive chemotherapy with the same drugs used for primary therapy and autologous hematopoietic cell transplantation (HCT). 42–44 As treatment of RB changed very little until the end of the 20th century, evaluation of the outcomes of historic therapies remains relevant.…”

Section: Retinoblastomamentioning

confidence: 99%

Relevance of historical therapeutic approaches to the contemporary treatment of pediatric solid tumors

Green¹,

Kun²,

Matthay³

et al. 2013

Pediatric Blood & Cancer

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Children with solid tumors, most of which are malignant, have an excellent prognosis when treated on contemporary regimens. These regimens, which incorporate chemotherapeutic agents and treatment modalities used for many decades, have evolved to improve relapse-free survival and reduce long-term toxicity. This review discusses the evolution of the treatment regimens employed for management of the most common solid tumors, emphasizing the similarities between contemporary and historical regimens. These similarities allow the use of historical patient cohorts to identify the late effects of successful therapy and to evaluate remedial interventions for these adverse effects.

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Section: Retinoblastomamentioning

confidence: 99%

Relevance of historical therapeutic approaches to the contemporary treatment of pediatric solid tumors

Green¹,

Kun²,

Matthay³

et al. 2013

Pediatric Blood & Cancer

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“…There is a wide spectrum of techniques used for retinoblastoma ranging from single fields to complex fields such as anterior lens sparing technique, lateral oblique fields, multiple non coplanar arcs, single anterior electron fields, stereotactic radiotherapy, conformal and intensity modulated radiotherapy plans. Even protons were used to perform homogeneous dose coverage of retina while sparing the lens and bony anatomy 5,10–13. IMRT for retinoblastoma was first reported by Krasin et al 5.…”

Section: Discussionmentioning

confidence: 99%

“…Even protons were used to perform homogeneous dose coverage of retina while sparing the lens and bony anatomy 5,10–13. IMRT for retinoblastoma was first reported by Krasin et al 5. Subsequently, Reisner et al published a comparative analysis of external radiotherapy techniques with IMRT in a case report of unilateral retinoblastoma 8.…”

Section: Discussionmentioning

confidence: 99%

Intensity modulated radiotherapy (IMRT) in bilateral retinoblastoma

Atalar¹,

Özyar²,

Günduz³

et al. 2010

Radiology and Oncology

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BackgroundExternal beam radiotherapy (EBRT) for retinoblastoma has traditionally been done with conventional radiotherapy techniques which resulted high doses to the surrounding normal tissues.Case reportA 20 month-old girl with group D bilateral retinoblastoma underwent intensity modulated radiotherapy (IMRT) to both eyes after failing chemoreduction and focal therapies including cryotherapy and transpupillary thermotherapy. In this report, we discuss the use of IMRT as a method for reducing doses to adjacent normal tissues while delivering therapeutic doses to the tumour tissues compared with 3-dimensional conformal radiotherapy (3DCRT). At one year follow-up, the patient remained free of any obvious radiation complications.ConclusionsImage guided IMRT provides better dose distribution than 3DCRT in retinoblastoma eyes, delivering the therapeutic dose to the tumours and minimizing adjacent tissue damage.

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“…The main limitation observed in this review is the publication of data of small series and short-term follow-up. In addition, the majority of studies investigated tumours located in the brain and CNS, with few other sites [8-10,13-15]. …”

Section: Introductionmentioning

confidence: 99%

On the performances of different IMRT treatment planning systems for selected paediatric cases

et al. 2007

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Intensity-modulated Radiation Therapy for Children with Intraocular Retinoblastoma:Potential Sparing of the Bony Orbit

Cited by 47 publications

References 28 publications

Relevance of historical therapeutic approaches to the contemporary treatment of pediatric solid tumors

Relevance of historical therapeutic approaches to the contemporary treatment of pediatric solid tumors

Intensity modulated radiotherapy (IMRT) in bilateral retinoblastoma

On the performances of different IMRT treatment planning systems for selected paediatric cases

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